A5054673342- HIV/AIDS Research and Interventions
- Global Maternal and Child Health
- Adolescent Sexual and Reproductive Health
- HIV Research and Treatment
- HIV, Drug Use, Sexual Risk
- HIV-related health complications and treatments
- Sex work and related issues
- HIV/AIDS Impact and Responses
- Poverty, Education, and Child Welfare
- HIV/AIDS drug development and treatment
- Hepatitis B Virus Studies
- Global Public Health Policies and Epidemiology
- Migration and Labor Dynamics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Healthcare Systems and Reforms
- Lipoproteins and Cardiovascular Health
- Herpesvirus Infections and Treatments
- Child Nutrition and Water Access
- Systemic Lupus Erythematosus Research
- Cytomegalovirus and herpesvirus research
- Gender, Labor, and Family Dynamics
- Reproductive tract infections research
- Blood groups and transfusion
- Adolescent and Pediatric Healthcare
Mildmay Uganda
2024-2025
Uganda Virus Research Institute
2009-2024
London School of Hygiene & Tropical Medicine
2015-2023
University of London
2023
Wellcome Sanger Institute
2013
Medical Research Council
2013
University of East Anglia
2013
The General Population Cohort (GPC) was set up in 1989 to examine trends HIV prevalence and incidence, their determinants rural south-western Uganda. Recently, the research questions have included epidemiology genetics of communicable non-communicable diseases (NCDs) address limited data on burden risk factors for NCDs sub-Saharan Africa. cohort comprises all residents (52% aged ≥13years, men women equal proportions) within one-half a sub-county, residing scattered houses, largely farmers...
Background: The rollout of antiretroviral therapy (ART) is one the largest public health interventions in Eastern and Southern Africa recent years. Its impact well described clinical cohort studies, but population-based evidence rare. Methods: We use data from seven demographic surveillance sites that also conduct community-based HIV testing collect information on uptake services. present crude death rates adults (aged 15–64) for period 2000–2011 by sex, status, treatment status. Parametric...
To describe trends in age at first sex (AFS), marriage (AFM) and time spent single between events to compare age-specific marital status six cohort studies.
Abstract Objective To provide a broad and up‐to‐date picture of the effect antiretroviral therapy (ART) provision on population‐level mortality in Southern East Africa. Methods Data all‐cause, AIDS non‐AIDS among 15–59 year olds were analysed from demographic surveillance sites (DSS) Karonga (Malawi), Kisesa (Tanzania), Masaka (Uganda) Africa Centre (South Africa), using Poisson regression. Trends over time up to 5 years prior ART roll‐out, 4–6 afterwards, are presented, overall by age sex....
Abstract Objective To investigate trends in all‐cause adult mortality after the roll‐out of an antiretroviral therapy (ART) programme rural Uganda. Methods Longitudinal population‐based cohort study approximately 20 000 residents Mortality adults aged 15–59 years was determined for 5‐year period (1999–2003) before introduction ART January 2004 and afterwards. Poisson regression used to estimate rate ratios (RRs) ART, 1 year (from 2005) more than introduction. Trends were analysed by HIV...
The Network for Analysing Longitudinal Population-based HIV/AIDS data on Africa (ALPHA Network, http://alpha.lshtm.ac.uk/) brings together ten population-based HIV surveillance sites in eastern and southern Africa, is coordinated by the London School of Hygiene Tropical Medicine (LSHTM).It was established 2005 aims to (i) broaden evidence base epidemiology informing policy, (ii) strengthen analytical capacity research, (iii) foster collaboration between network members.All study sites, some...
To compare reported numbers of sexual partners in Eastern and Southern Africa.
Objective: To estimate the impact of antiretroviral therapy (ART) on population-wide adult life expectancy (LE). Study design:A population-based open cohort study with repeated HIV status measurements and registration vital events in south-western Uganda (1991Uganda ( -2012)).Methods: Non-parametric survival analysis techniques are used for estimating trends (i) LE general population (aged 15 above), (ii) by status, (iii) deficit associated HIV.The is estimated as difference between overall...
<title>Abstract</title> <bold>Background: </bold>Despite global efforts to improve HIV care, late identification and delayed antiretroviral therapy (ART) initiation continue pose mortality risks among people living with (PLHIV) advanced disease (AHD). This study investigated factors associated PLHIV AHD in rural North-Central Uganda from January 2018 December 2021. <bold>Methods</bold>: We conducted a retrospective review of electronic medical records 18 health facilities, obtained data on...
To derive the best possible estimates of trends in age at first sex (AFS) among successive cohorts Ugandan men and women based on all data available from Demographic Health Surveys (DHS) cohort studies Masaka Rakai districts.The datasets DHS, were analysed separately. Survival analysis methods used to estimate median AFS for born 1950s-1980s compute hazard ratios sex, comparing later with earlier cohorts.The DHS showed an increase more recent birth compared those before 1970, but this was...
The role of concurrent sexual partnerships in the HIV epidemic sub-Saharan Africa is not well understood. Although most infections occur among married individuals, transmission may from both spousal and extraspousal partnerships. This article explores as a form concurrency, examining association with status, demographic characteristics, behaviors population-based cohort rural Uganda.Prevalence was estimated using cross-sectional data 2008, adjusted odds ratios (aOR) were for factors...
<h3>Objectives:</h3> To assess inconsistencies in reported age at first sex (AFS) and marriage (AFM) three African cohorts, consider their implications for interpreting trends sexual marital debut. <h3>Methods:</h3> Data were analysed from population-based cohort studies Zimbabwe, Uganda South Africa with 3, 10 4 behavioural survey rounds, respectively. Three rounds over a similar time frame selected each site comparative purposes. The consistency of AFS AFM reports was assessed by comparing...
Background . Hypertension and dyslipidemia are independent risk factors for coronary heart disease commonly coexist. Cardiovascular can be reliably predicted using lipid ratios such as the atherogenic index, a useful prognostic parameter guiding timely interventions. Objective We assessed cardiovascular profile based on index of residents within rural Ugandan cohort. Methods In 2011, population survey was conducted among 7507 participants. Sociodemographic characteristics, physical...
Abstract Objectives To investigate antiretroviral therapy (ART) uptake after its introduction in 2004 a longitudinal population‐based cohort and nested clinical rural Uganda. Methods A HIV serosurvey of all adults aged ≥15 years is conducted annually. Two intervals were selected for analysis. Interval 1 (November 2004–October 2006) provided 2 follow‐up to prospectively evaluate access services. 2007–October 2008) was used current coverage Logistic regression identify sociodemographic factors...
High attrition and irregular testing for human immunodeficiency virus (HIV) in cohort studies high-risk populations can bias incidence estimates. We compare trends women attending a dedicated HIV prevention treatment clinic, using common methods assigning when seroconversion occurs whether among those with attrition.Between April 2008 May 2009, were enrolled into 1 from January 2013 2, then scheduled follow-up once every 3 months. Incidence based on assuming midpoint the interval compared of...
Abstract Objective The risk of stroke rises after episodes herpes zoster and chickenpox, which are caused by varicella virus ( VZV ). We conducted a pilot case–control study stroke, nested within long‐standing cohort in U ganda (the G eneral P opulation C ohort), to examine antibodies against prior diagnosis. Methods used stored sera the evolution I g M among 31 clinically confirmed cases 132 matched controls. For each participant, three samples were identified: one each, taken at or near...
Abstract Objectives To present a simple method for estimating population‐level anti‐retroviral therapy (ART) need that does not rely on knowledge of past HIV incidence. Methods A new approach to ART is developed based calculating age‐specific proportions HIV‐infected adults expected die within fixed number years in the absence treatment. Mortality data pre‐treatment era from five African cohort studies were combined construct life table, starting at age 15, smoothed with Weibull model....
To document the changes in HIV incidence over thirty years Kalungu district, Uganda.Since 1989, residents aged ≥15 old have been tested for HIV, and data were collected on risk factors annually later, biennially Kyamulibwa open cohort. In 2019-2021 survey, people living with self-reported knowledge of their status, antiretroviral therapy (ART) use, most recent viral load obtained from health facilities. The seroconversion dates randomly imputed between last negative first positive test using...
Abstract Background With the double burden of rising chronic non-communicable diseases (NCDs) and persistent infectious facing sub-Saharan Africa, integrated health service delivery strategies among resource-poor countries are needed. Our study explored post-trial sustainability a system intervention to improve NCD care, introduced during cluster randomised trial between 2013 2016 in Uganda, focusing on hypertension (HT) type-2 diabetes mellitus (DM) services. In 2020, 19 38 primary care...
Background: Although there has been substantial global progress in decreasing child mortality over the past two decades, sub-Saharan Africa largely lagged behind. The temporal trends and associated risk factors were investigated a cohort of children rural Uganda.Methods: Information on children’s vital status, delivery, breastfeeding, vaccination history, maternal HIV status for 1993–2007 was retrieved from Medical Research Council/Uganda Virus Institute’s (MRC/UVRI) Annual Population Census...
There is limited evidence on the relationship between sustained exposure of female sex workers (FSWs) to targeted HIV programmes and incidence. We investigate number missed study visits (MSVs) within each episode 2 consecutively attended subsequent risk in a predominantly FSW cohort. Women at high are invited attend an ongoing dedicated clinic offering combination prevention intervention Kampala, Uganda. Study scheduled once every 3 months. The analysis included HIV-seronegative women with...
<title>Abstract</title> Dolutegravir (DTG), a key component of the recommended HIV treatment regimens in Uganda, has been associated with hyperglycemia. We evaluated its influence on hyperglycemia risk to create stratification tool guide patients’ monitoring. conducted prospective cohort study at three selected sites, involving 628 patients who had Tenofovir Disoproxyl Fumarate, Lamivudine, and (TLD). Patients were divided into those prior Nucleoside reverse transcriptase inhibitors...
Dolutegravir (DTG), a key component of the recommended human immunodeficiency virus (HIV) treatment regimens in Uganda, has been associated with hyperglycemia. We evaluated its influence on hyperglycemia risk to create stratification tool for patient monitoring.
People with disability are a vulnerable population and at high risk of acquiring human immunodeficiency virus (HIV) infection. We investigated the association between severity not having knowledge any HIV prevention method among adults in Uganda. Between January 2015 December 2015, data were collected within general Uganda, on six domains based Washington Group Short Set Functioning. In addition, routine socio-demographic factors other HIV-related aged 16 years above. A continuum functioning...