Eriodictyol isolated from Dendrobium ellipsophyllum provides health benefits in several oxidative stress-related diseases. This study aimed to determine the protective effect and mechanisms of eriodictyol on hydrogen peroxide (H 2 O )-induced cell death neuronal SH-SY5Y cells. The against H was evaluated by resazurin assay. Reactive oxygen species (ROS) mitochondrial membrane potential were detected 2´-7´ dichlorodihydrofluorescein diacetate (DCFH-DA) tetramethylrhodamine ethyl ester (TMRE)...

A methanol extract from the whole plant of Dendrobium formosum Roxb. ex Lindl., Orchidaceae, showed inhibitory potential against α-glucosidase and pancreatic lipase enzymes. Chromatographic separation resulted in isolation twelve phenolic compounds. The structures these compounds were determined through analysis NMR HR-ESI-MS data. All isolates evaluated for their activities, as well glucose uptake stimulatory effect. Among isolates, 5-methoxy-7-hydroxy-9,10-dihydro-1,4-phenanthrenequinone...

Lung cancer is one of the most common causes death due to its high metastasis potential. The process migration an early step that required for successful metastasis. discovery and development natural compounds therapy have garnered increasing attention in recent years. Gigantol (1) a bibenzyl compound derived from Thai orchid, Dendrobium draconis. It exhibits significant cytotoxic activity against several cell lines; however, until recently, role 1 on tumor has not been characterized. This...

A new dimeric stilbene, namely, artogomezianol (1), and the known compound andalasin (2) were isolated from roots of Artocarpus gomezianus. Both 1 2 showed moderate tyrosinase inhibitory activity with IC50 values 68 39 μM, respectively.

From the leaves of Millettia erythrocalyx, a new flavone named 3',5'-dimethoxy-[2",3": 7,8]-furanoflavone and three known compounds were isolated. Assays for anti-herpes simplex virus activity (HSV-1 HSV-2) performed on 24 phenolic obtained from M. erythrocalyx Artocarpus lakoocha. It was found that flavones ovalifolin, pongol methyl ether millettocalyxin A, stilbene oxyresveratrol possessed moderate against both types HSV. In addition, evaluated potential anti-HIV wild-type human...

Chromatographic separation of a methanol extract prepared from the whole plant Dendrobium brymerianum led to isolation eight phenolic compounds. Among isolated compounds ( 1 – 8 ), moscatilin gigantol 3 lusianthridin 4 and dendroflorin 6 ) showed appreciable cytotoxicity against human lung cancer cell lines with IC 50 values 196.7, 23.4, 65.0, 125.8 μ g/mL, respectively, exhibited antimigratory property at nontoxic concentrations. This study is first report on biological activities this plant.

Oxidative stress in dermal fibroblasts is strongly correlated with the aging process of skin. The application natural compounds that can increase ability to counteract oxidative a promising approach promote skin health and beauty. Eriodictyol flavonoid exerts several pharmacological actions through its antioxidant properties. However, protective effects on have not yet been investigated. In this study, we investigated whether eriodictyol protects human (BJ fibroblasts) from harmful hydrogen...

Lung cancer is the leading cause of death among patients worldwide, and most them have died from metastasis. Migration invasion are prerequisite processes associated with high metastasis potential in cancers. Moscatilin, a bibenzyl derivative isolated Thai orchid Dendrobium pulchellum , has been shown to anticancer effect against numerous cell lines. However, little known regarding moscatilin on migration invasion. The present study demonstrates that nontoxic concentrations were able inhibit...

Roots of Boesenbergia rotunda (L.) Mansf. are prominent ingredients in the cuisine several Asian countries, including Thailand, Malaysia, Indonesia, India, and China. An extract prepared from roots this plant showed strong inhibitory activity against enzymes α-glucosidase pancreatic lipase was subjected to chromatographic separation identify active components. Three new biflavonoids flavanone-chalcone type (9, 12, 13) were isolated, along with 12 known compounds. Among 15 isolates, three...

Lung cancer remains a leading public health problem as evidenced by its increasing death rate. The main cause of in lung patients is metastasis. metastatic behavior cells becomes enhanced when undergo epithelial to mesenchymal transition (EMT). Gigantol, bibenzyl compound extracted from the Thai orchid, Dendrobium draconis, has been shown have promising therapeutic potential against cells, which leads hypothesis that gigantol may be able inhibit fundamental EMT process cells. This study...

Five compounds including a new bisbibenzyl named dendropachol (1) and four known (2–5) comprising 4,5-dihydroxy-2,3-dimethoxy-9,10-dihydrophenanthrene (2), gigantol (3), moscatilin (4) 4,5,4′-trihydroxy-3,3′-dimethoxybibenzyl (5) were isolated from methanolic extract of Dendrobium pachyglossum (Orchidaceae). The chemical structures the characterized by spectroscopic methods. Dendropachol was investigated for its protective effects on hydrogen peroxide (H2O2)-induced oxidative stress in HaCaT...

A number of Dendrobium species (Orchidaceae) have been used as health foods. In Thailand, the tea prepared from stems draconis Rchb.f. has a blood tonic. Our phytochemical investigation this plant led to isolation new compound namely 5-methoxy-7-hydroxy-9,10-dihydro-1,4-phenanthrenequinone (1), along with four known stilbenoids including hircinol (2), gigantol (3), batatasin III (4), and 7-methoxy-9,10-dihydrophenanthrene-2,4,5-triol (5). The structures these compounds were determined...

A MeOH extract from the whole plant Dendrobium venustum exhibited significant antimalarial and anti-herpetic activities. Bioassay-guided isolation of resulted in seven known phenolic compounds. Densiflorol B (3) phoyunnanin E (6) showed strongest activity a high selectivity index, whereas gigantol (2), batatasin III (5) C (7) moderate activity. Compounds 2 5 also weak against Herpes simplex virus. This study is first report on chemical biological activities D. venustum.

Oxyresveratrol (2,4,3′,5′-tetrahydroxystilbene, 1), a phytoalexin present in large amounts the heartwood of Artocarpus lacucha Buch.-Ham., has been reported to possess wide variety biological activities. As part our continuing studies on structural modification oxyresveratrol, library twenty-six compounds was prepared via O-alkylation, aromatic halogenation, and electrophilic substitution. The two rings stilbene system 1 can be chemically modulated by exploiting different protecting groups....

Phytochemical investigation of the whole plant Dendrobium scabrilingue resulted in isolation two new compounds namely dendroscabrols A (1) and B (2), along with eight known (3–10). The structures these were determined by NMR HR-ESI-MS experiments. All isolates evaluated for their α-glucosidase inhibitory effect. Dendroscabrol (2) RF-3192C (10) showed most potent activity. (1), gigantol (5), coelonin (7) lusianthridin (9) also exhibited strong activity as compared positive control acarbose.

Dendrobium plants are widely used in traditional Chinese medicine. Their secondary metabolites such as bibenzyls and phenanthrenes show various pharmacological benefits immunomodulation inhibitory effects on cancer cell growth. However, our previous study also showed that some of these promising compounds (i.e., gigantol cypripedin) induced the expression inflammatory cytokines including TNF human monocytes, thus raising concerns about use clinical application. Furthermore, other immune...

Bibenzyls and dihydrophenanthrenes exhibit promising immunomodulatory effects in various human diseases. In this study, we isolated one new dihydrophenanthrene derivative (1), two bibenzyl-dihydrophenanthrene derivatives (2, 3) along with 12 known compounds (4-15) from the methanol extract of Calanthe cardioglossa. These were identified by using physicochemical analyses spectroscopic methods. The three possess enantiomeric forms, their configurations determined comparing experimental...