Research in metagenomics and metaproteomics can reveal how microbiological interactions fermented foods contribute to their health benefits. This study examined three types of vegetables: a standard formulation, probiotic formulation with Lacticaseibacillus rhamnosus GG, polyphenol vitexin from Mung bean seed coat. Measurements were taken at day 0 (after 36 h fermentation room temperature) after 15 days. We applied 16S rRNA sequencing evaluate microbial diversity utilized LC-MS/MS...

Abstract Objective: This study assessed nutritional status among Thai children using anthropometry, dietary intakes and micronutrient status. Design: Cross-sectional survey with multi-stage cluster sampling. Body weight height were measured in all children. Dietary 24-h recall. Biochemical assessment was performed one-third of the Setting: The conducted Thailand’s four geographical regions Bangkok. Participants: 3478 aged 0·5–12·9 years. Results: Stunting showed a downward trend by age group...

Oxidative stress in dermal fibroblasts is strongly correlated with the aging process of skin. The application natural compounds that can increase ability to counteract oxidative a promising approach promote skin health and beauty. Eriodictyol flavonoid exerts several pharmacological actions through its antioxidant properties. However, protective effects on have not yet been investigated. In this study, we investigated whether eriodictyol protects human (BJ fibroblasts) from harmful hydrogen...

Lime peels are food waste from lime product manufacturing. We previously developed and optimized a green extraction method for hesperidin-limonin-rich peel extract. This study aimed to identify the metabolomics profile of phytochemicals anti-cancer effects ethanolic extract (Citrus aurantifolia) against liver cancer cells PLC/PRF/5. The extract's was analyzed by using LC-qTOF/MS GC-HRMS. were studied MTT assay, Annexin-PI Transwell-invasion assay. Results show that average IC50(s)...

Abstract Excessive oxidative toxicity in liver cells is a significant risk factor that can cause cellular injury, leading to the development of chronic disease (CLD). Natural anthocyanins have been shown prevent harmful effects mammalian cells. Ripe Cleistocalyx nervosum var. paniala berry fruits are rich anthocyanins, which reported possess many health benefits. Therefore, this study examined protective effect ethanolic fruit extract C. (CNPE) against hydrogen peroxide (H 2 O )‐induced...

Oxidative stress-induced damage to the retinal pigmented epithelium (RPE), a specialised post-mitotic monolayer that maintains homeostasis, contributes development of age-related macular degeneration (AMD). Curcumin (Cur), naturally occurring antioxidant, was previously shown have ability protect RPE cells from oxidative stress. However, poor solubility and bioavailability makes Cur therapeutic agent. As prodrug approaches can mitigate these limitations, we compared protective properties...

ABSTRACT In this work, a curcumin-diglutaric acid (CurDG) prodrug was synthesized by conjugation of curcumin with glutaric via an ester linkage. The water solubility, partition coefficient, release characteristics, and antinociceptive activity CurDG were compared to those curcumin. aqueous solubility (7.48 μg/mL) is significantly greater than that (0.068 μg/mL). A study in human plasma showed the completely releases within 2 h, suggesting ability serve as hot plate test mice highest effect...

Curcumin diglutaric acid (CurDG), an ester prodrug of curcumin, has the potential to be developed as anti-inflammatory agent due its improved solubility and stability. In this study, effects CurDG were evaluated. The on inflammatory mediators evaluated in LPS-stimulated RAW 264.7 macrophage cells. reduced increased levels NO, IL-6, TNF- α, well iNOS COX-2 expression cells a greater extent than those along with potent inhibition MAPK (ERK1/2, JNK, p38) activity. assessed vivo by employing...

Five compounds including a new bisbibenzyl named dendropachol (1) and four known (2–5) comprising 4,5-dihydroxy-2,3-dimethoxy-9,10-dihydrophenanthrene (2), gigantol (3), moscatilin (4) 4,5,4′-trihydroxy-3,3′-dimethoxybibenzyl (5) were isolated from methanolic extract of Dendrobium pachyglossum (Orchidaceae). The chemical structures the characterized by spectroscopic methods. Dendropachol was investigated for its protective effects on hydrogen peroxide (H2O2)-induced oxidative stress in HaCaT...

Oxidative stress-induced cell damage and death of the retinal pigmented epithelium (RPE), a polarized monolayer that maintains health homeostasis, lead to development age-related macular degeneration (AMD). Several studies show naturally occurring antioxidant Lutein (Lut) can protect RPE cells from oxidative stress. However, poor solubility low oral bioavailability limit potential Lut as therapeutic agent. In this study, lutein diglutaric acid (Lut-DG), prodrug Lut, was synthesized its...

Fermented vegetables are increasingly being recognized as an important dietary component, particularly of plant-based diets, to achieve a sustainable healthy gut because their microbial diversity and antioxidant properties. However, the functional relevance fermented varies based on raw ingredients used nutrient supplementation. Therefore, in present study, we investigated activity three formulas (standard, supplemented with Lacticaseibacillus rhamnosus GG, polyphenol vitexin) at days 0 15....

Curcumin diethyl disuccinate (CDD) is a succinate prodrug of curcuminoids that has better stability in human plasma and improved vitro cytotoxicity compared to curcumin. Therefore, CDD the potential for further development as an anticancer agent. In this study, we focused on optimization formulation CDD-loaded chitosan/alginate nanoparticles using Box-Behnken statistical design enhance therapeutic efficacy CDD. Oil-in-water emulsification followed by ionotropic gelification was used prepare...

Abstract Curcumin (Cur) has been reported to have anti-hepatocellular carcinoma activity but its poor oral bioavailability limits further development as a chemotherapeutic agent. We synthesized previously succinate ester prodrug of Cur, curcumin diethyl disuccinate (CurDD) with better chemical stability in buffer solution pH 7.4. Here, we investigated and compared the cellular transport anti-proliferative against HepG2 cells CurDD Cur. Transport across Caco-2 monolayers provided...

Psoriasis is a chronic inflammatory skin disease characterized by hyperproliferation of the epidermal cells and clinically presented as thick, bright red to pink plaques with silvery scale. Photodynamic therapy (PDT) using visible light has become increasing interest in treatment diseases. In this study, we demonstrate that combination curcumin-loaded chitosan/alginate nanoparticles (Cur-CS/Alg NPs) blue emitting diodes (LED) irradiation effectively suppressed tumor necrosis factor-alpha...

Curcumin diglutaric acid-loaded polyethylene glycol-chitosan oligosaccharide-coated superparamagnetic iron oxide nanoparticles (CG-PEG-CSO-SPIONs) were fabricated by co-precipitation and optimized using a Box–Behnken statistical design in order to achieve the minimum size, optimal zeta potential (≥ ±20 mV), maximum loading efficiency capacity. The results demonstrated that CG-PEG-CSO-SPIONs prepared under condition almost spherical shape with smooth surface, diameter of 130 nm, 30.6 mV,...

A hyaluronic acid-grafted poly(N-isopropylacrylamide) (HA-pNIPAM) was synthesized as a polymeric nanogel platform for encapsulation and delivery of hydrophobic bioactive compounds using curcumin model drug. As demonstrated by transmission electron microscopy dynamic light scattering techniques, the HA-pNIPAM simply assembled into spherical nano-sized particles with thermoresponsive behavior. The success aqueous solubilization confirmed fluorescent spectroscopy. resulting formulation enhanced...

Green extraction is aimed at reducing energy consumption by using renewable plant sources and environmentally friendly bio-solvents. Lime (