A5038881810- Mesenchymal stem cell research
- Acute Kidney Injury Research
- Reproductive Biology and Fertility
- Tissue Engineering and Regenerative Medicine
- Viral Infectious Diseases and Gene Expression in Insects
- Sperm and Testicular Function
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Pluripotent Stem Cells Research
- Mitochondrial Function and Pathology
- MicroRNA in disease regulation
- Toxin Mechanisms and Immunotoxins
- Heme Oxygenase-1 and Carbon Monoxide
- Transgenic Plants and Applications
- Ferroptosis and cancer prognosis
- Neonatal Respiratory Health Research
- Radiation Therapy and Dosimetry
- Erythrocyte Function and Pathophysiology
- Renal and related cancers
- Genomics, phytochemicals, and oxidative stress
- Electrospun Nanofibers in Biomedical Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- RNA modifications and cancer
- Animal Genetics and Reproduction
- RNA Interference and Gene Delivery
Guilan University of Medical Sciences
2016-2025
Kagoshima University
2020-2025
High Institute for Education and Research in Transfusion Medicine
2011-2020
Biotechnology Research Center
2017-2018
Iranian Legal Medicine Organization
2007-2016
Tohoku University
2006-2016
Tehran University of Medical Sciences
2006
University of Tehran
2006
Pasteur Institute of Iran
2006
Lipocalin 2 (Lcn2, NGAL) is a member of the lipocalin superfamily with diverse functions such as transport fatty acids and induction apoptosis. Previous reports indicated that expression Lcn2 induced under harmful conditions. However, mechanisms remain to be elucidated. In this report, we intended identify factor or factors induce expression. Up-regulation after X-ray exposure was detected in heart, kidney especially liver. Primary culture liver component cells revealed up-regulation...
The most prominent capabilities of mesenchymal stem cells (MCSs) which make them promising for therapeutic applications are their capacity to endure and implant in the target tissue. However, these limited due early death within first few days following transplantation. Therefore, improve cell therapy efficacy, it is necessary manipulate MSCs resist severe stresses imposed by microenvironment. In this study, we manipulated express a cytoprotective factor, nuclear factor erythroid-2 related 2...
To investigate the effects ofellagic acid (EA) on cytotoxicity, B-lymphocytes isolated from CLL patients and healthy individuals. Flow cytometric assay was used to measure percentage of apoptosis versus necrosis, intracellular active oxygen radicals (ROS), mitochondrial membrane potential (MMP) caspase-3 activity then mitochondria were both groups parameters toxicity investigated. Based our results EA decreased viable cells induced apoptosis. increased ROS formation, swelling, MMP decrease...
Radiotherapy is a well-established treatment for cancer. However, the existence of radioresistant cells one major obstacles in radiotherapy. In order to understand mechanism cellular radioresistance and develop more effective radiotherapy, we have established clinically relevant (CRR) cell lines, which continue proliferate under daily exposure 2 Gray (Gy) X-rays >30 days. X-ray irradiation significantly induced autophagic parental cells, was exiguous CRR suggesting that death involved...
In cancer therapy, radioresistance or chemoresistance cells are major problems. We established clinically relevant radioresistant (CRR) that can survive over 30 days after 2 Gy/day X-ray exposures. These also show resistance to anticancer agents and hydrogen peroxide (H2O2). have previously demonstrated all the CRR examined had up-regulated miR-7-5p knockdown, they lost radioresistance. However, mechanism of losing remains be elucidated. Therefore, we investigated role in by knockdown using...
Neutrophil Gelatinase-Associated Lipocalin (NGAL/Lcn2), a member of the lipocalin family, has variety functions. There are extensive studies examining expression NGAL under harmful conditions. However, its precise function remains poorly understood. Heme Oxygenase 1 (HO-1) is an enzyme with well-established cytoprotective effects. Previous work showed that induces HO-1. Interestingly, same stimuli induced both and The current study was designed to (1) determine whether exerts effect through...
We investigated the effect of chrysin on isolated normal and chronic lymphocytic leukemia (CLL) B-lymphocytes their mitochondria. report that a selective significant increase in cytotoxicity, intracellular reactive oxygen species, mitochondrial membrane potential collapse, ADP/ATP ratio, caspase 3 activation finally apoptosis chrysin-treated CLL B- lymphocytes. Also we determined selectively inhibits complex II ATPases cancerous In this study proved ability to promote performed by targeting...
Lipocalin-2 (Lcn2, NGAL) is a member of the lipocalin super family with diverse function such as induction apoptosis, suppression bacterial growth, and modulation inflammatory response. Much interest has recently been focused on physiological/pathological role lipocalin-2 that considered to be novel protective factor against oxidative stress. However, its precise biological roles in this protection are not fully understood. In report we intended test effect expression heme oxygenase ((1, 2))...
Despite many advantages of mesenchymal stem cells (MSCs) that make them suitable for cell therapy purposes, their therapeutic application has been limited due to susceptibility several stresses (e.g., nutrient-poor environment, oxidative stress, and hypoxic masses cytotoxic factors) which they are exposed during preparation following transplantation. Hence, reinforcing MSCs against these is a challenge both basic clinician scientists. Recently, much attention directed toward equipping with...
The present study investigates the in vitro and vivo effect of acacetin (4'-methoxy-5,7-dihydroxyflavone) on chronic lymphocytic leukemia (CLL) B-lymphocytes mitochondria. CLL healthy were obtained from patients donors, respectively. Mitochondria isolated both groups. Xenografts severe combined immune deficient mice used to examine toxicity anti activity acacetin. We evaluated compared mechanism action their have found that (10 μM) can selectively induce apoptosis B-lymphocyte (25% at 24 h)...