A5014087878- Esophageal Cancer Research and Treatment
- Trauma and Emergency Care Studies
- Injury Epidemiology and Prevention
- Esophageal and GI Pathology
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Emergency and Acute Care Studies
- RNA modifications and cancer
- Colorectal Cancer Screening and Detection
- Gastrointestinal Bleeding Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Global Health and Surgery
- Traffic and Road Safety
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal disorders and treatments
- Hip and Femur Fractures
- Global Health Workforce Issues
- Cardiac Arrest and Resuscitation
- Helicobacter pylori-related gastroenterology studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Appendicitis Diagnosis and Management
- Abdominal Trauma and Injuries
- Head and Neck Cancer Studies
- Lung Cancer Diagnosis and Treatment
Kamuzu Central Hospital
2014-2024
University of North Carolina at Chapel Hill
2018-2020
University of North Carolina Health Care
2020
Thomas Jefferson University
2018-2019
National Cancer Institute
2017-2018
Tenwek Hospital
2018
University of California, San Francisco
2018
National Institutes of Health
2017
Malawi-Liverpool-Wellcome Trust Clinical Research Programme
2017
Ministry of Health
2017
Esophageal squamous cell carcinoma (ESCC) is endemic in regions of sub-Saharan Africa (SSA), where it the third most common cancer. Here, we describe whole-exome tumor/normal sequencing and RNA transcriptomic analysis 59 patients with ESCC Malawi. We observed similar genetic aberrations as reported Asian North American cohorts, including mutations TP53, CDKN2A, NFE2L2, CHEK2, NOTCH1, FAT1, FBXW7. Analyses for nonhuman sequences did not reveal evidence infection HPV or other occult pathogens....
Background and study aims Limited evidence suggests that endoscopy capacity in sub-Saharan Africa is insufficient to meet the levels of gastrointestinal disease. We aimed quantify human material resources for services eastern African countries, identify barriers expanding capacity. Patients methods In partnership with national professional societies, digestive healthcare professionals participating countries were invited complete an online survey between August 2018 2020. Results Of 344...
Objective Esophageal cancer is the second commonest in Malawi, and 95% of all cases are esophageal squamous cell carcinoma (ESCC). Very little known about epidemiology ESCC Malawi including risk factors. The main objective study was to evaluate describe factors Malawi. Methods We conducted a case-control from 2017 2020 at two hospitals Lilongwe, consenting adults were eligible for inclusion. Endoscopy on biopsies obtained histological confirmation. Controls selected patients or their...
Safe and reliable transfusion services remain largely unavailable to the world's poorest populations, particularly in sub-Saharan Africa.1Kralievits KE Raykar NP Greenberg SL Meara JG The global blood supply: a literature review.Lancet. 2015; 385: S28Summary Full Text PDF PubMed Google Scholar WHO responded this crisis with strategy focused on centralising services, exclusive use of volunteer donors, donor testing, stewardship.2The LancetImproving safety worldwide.Lancet. 2007; 370:...
Background Alcohol consumption is a well-known risk factor for sustaining road traffic injuries worldwide. Malawi low-income country with large and increasing burden of injuries. It has generally been viewed as relatively little alcohol consumption. This study investigates the role in around capital Lilongwe.Methods All patients presenting to emergency department Kamuzu Central Hospital after being injured crashes were asked participate study. testing was done breathalyzer or saliva test....
The incidence of esophageal squamous cell carcinoma (ESCC) is disproportionately high in the eastern corridor Africa and parts Asia. Emerging research has identified a potential association between poor oral health ESCC. One possible link ESCC involves alteration microbiome. We performed an integrated analysis four independent sequencing efforts tumors from patients high- low-incidence regions world. Using whole genome (WGS) RNA (RNAseq) 61 Tanzania, we community bacteria, including members...
Peritonitis is a life-threatening condition with multitude of etiologies that can vary geographic location. The aims this study were to elucidate the etiology, clinical presentation and outcomes associated peritonitis in Lilongwe, Malawi.All patients admitted Kamuzu Central Hospital (KCH) who underwent an operation for treatment during calendar year 2008 eligible. was defined as abdominal rigidity, rebound tenderness, and/or guarding one or more quadrants. Subjects identified from review...
Objective Alcohol or drug impairment is a major risk factor for road traffic crashes, and studies on this issue are essential to provide evidence-based data policymakers. In low- middle-income countries (LMICs), such often conducted in partnership with one more organizations high-income (HICs). The aim of article recommendations improving project planning decision-making processes epidemiological alcohol, safety LMICs involving HICs.
Background: Upper gastrointestinal bleeding (UGIB) is a medical emergency. Timely and appropriate treatment can be lifesaving. Where equipment supplies are inadequate, management of upper challenging. Methods: A retrospective review charts patients who were admitted during the year 2010, with diagnosis Gastrointestinal Bleeding (UGIB), was done at Kamuzu Central Hospital, Lilongwe, Malawi. Rockall score applied to determine mortality risk. Results: total number 187 records (119 men 68 women,...
BackgroundRoad traffic injuries are a leading cause of death and disability, especially in low- middle-income countries. Identifying injury hotspots valuable for introducing preventive measures. This is usually accomplished by using police data, but these often unreliable low-income study aimed to identify collecting geographical data the emergency room.MethodsThis was cross-sectional adult road patients presenting Casualty Department central hospital Lilongwe, capital Malawi. An electronic...
PURPOSE Esophageal cancer (EC) is the second most common in Malawi, with esophageal squamous cell carcinoma (ESCC) representing >90% of all ECs. Despite significant morbidity and mortality, little known about disease outcomes. In this study, we assess survival after ESCC diagnosis Malawi. METHODS We report on cases enrolled a case-control study at Kamuzu Central Hospital Lilongwe from August 2017 to April 2020. Suspected completed questionnaire interview; provided blood, urine, saliva...
Abstract Objectives To present the validation of a verbal autopsy ( VA ) tool using inpatient deaths in order to ultimately assess burden adult pre‐hospital trauma mortality Lilongwe, Malawi. Methods A WHO was administered at Kamuzu Central Hospital KCH morgue Lilongwe family members deceased. Two physicians assigned cause death as ‘trauma’ or ‘non‐trauma’ well standard based on tool. These assignments were compared ‘gold standard’ physician review hospital records kappa statistic. Results...
The contribution of interpersonal violence (IPV) to trauma burden varies greatly by region. high rates IPV in sub-Saharan Africa are thought relate part the collective violence. Malawi, a country with no history internal violence, provides an excellent setting evaluate whether drives this region.This is retrospective review prospective registry from 2009 through 2016 at Kamuzu Central Hospital Lilongwe, Malawi. Adult (>16 years) victims were compared non-intentional victims. Log binomial...
Trauma is among the leading causes of death and disability in both adults children worldwide. In Malawi, trauma patients are commonly brought dead (BID). We aimed to describe prevalence, sociodemographic, injury-related characteristics BID Kamuzu Central Hospital (KCH), a referral hospital Lilongwe, Malawi. retrospectively reviewed records all surveillance registry at KCH from February 2008 September 2019. excluded that did not present emergency centre, were instead taken mortuary directly....
Esophageal squamous cell carcinoma (ESCC) is a major cause of cancer morbidity and mortality in Eastern Africa. The majority patients with ESCC Africa present advanced disease at the time diagnosis. Several palliative interventions for are currently use within region, including chemotherapy, radiation therapy without esophageal stenting self-expandable metallic stents; however, comparative effectiveness these low resource setting has yet to be examined. This prospective, observational,...
The eastern corridor of Africa is affected by a high burden esophageal cancer (EC), with > 90% patients presenting advanced disease. Self-expanding metal stents (SEMS) have been previously reported as safe and effective for palliation malignant dysphagia in resource-limited settings; however, access limited throughout Eastern Africa.