A5085216803- Neonatal Respiratory Health Research
- Mesenchymal stem cell research
- Neonatal and fetal brain pathology
- Congenital Diaphragmatic Hernia Studies
- Preterm Birth and Chorioamnionitis
- Intimate Partner and Family Violence
- Anesthesia and Neurotoxicity Research
- Neuroscience of respiration and sleep
- Tissue Engineering and Regenerative Medicine
- Child Abuse and Trauma
- Biomedical Ethics and Regulation
- Web and Library Services
- Neurogenesis and neuroplasticity mechanisms
- Immunotherapy and Immune Responses
- Spine and Intervertebral Disc Pathology
- Hematopoietic Stem Cell Transplantation
- Musculoskeletal pain and rehabilitation
- IL-33, ST2, and ILC Pathways
- Child Welfare and Adoption
- Pluripotent Stem Cells Research
- Cerebral Palsy and Movement Disorders
- Immune Response and Inflammation
- Infant Development and Preterm Care
- Open Education and E-Learning
- Pediatric health and respiratory diseases
Hudson Institute of Medical Research
2016-2025
Monash University
2013-2024
Portland State University
2023
Hudson Institute
2022
KU Leuven
2022
Europe Hospitals
2022
British Columbia Children's Hospital
2022
University of Toronto
2022
Hospital for Sick Children
2022
SickKids Foundation
2022
The incidence of prostate cancer is frequent, occurring in almost one-third men older than 45 years. Only a fraction the cases reach stages displaying clinical significance. Despite advances our understanding carcinogenesis and disease progression, knowledge this still fragmented. Identification genes patterns gene expression will provide more cohesive picture biology.In study, we performed comprehensive analysis on 152 human samples including tissues, tissues adjacent to tumor, organ donor...
Multiple sclerosis involves demyelination and axonal degeneration of the central nervous system. The molecular mechanisms are relatively unexplored in both multiple its mouse model, experimental autoimmune encephalomyelitis. We previously reported that targeting growth inhibitor, Nogo-A, may protect against neurodegeneration encephalomyelitis; however, mechanism by which this occurs is unclear. now show collapsin response mediator protein 2 (CRMP-2), an important tubulin-associated regulates...
Mesenchymal stem cells (MSCs) are efficacious in a variety of intractable diseases. While bone marrow (BM)-derived MSCs (BM-MSCs) have been widely investigated, from other tissue sources also shown to be effective several autoimmune and inflammatory disorders. In the present study, we simultaneously assessed therapeutic efficacy human BM-MSCs, as well isolated adipose (Ad-MSCs) umbilical cord Wharton's jelly (UC-MSCs), experimental encephalomyelitis (EAE), an animal model for multiple...
It is well understood that hypoxic-ischemic (HI) brain injury during the highly vulnerable perinatal period can lead to cerebral palsy, most prevalent cause of chronic disability in children. Recently, human clinical trials have reported safety and some efficacy following treatment palsy using umbilical cord blood (UCB) cells. UCB made up many different cell types, including endothelial progenitor cells (EPCs), T regulatory (Tregs), monocyte-derived suppressor (MDSCs). How each type...
Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system (CNS). In recent years, it has been found that cells such as human amnion epithelial (hAECs) have ability to modulate immune responses in vitro and vivo can differentiate into multiple cell lineages. Accordingly, we investigated immunoregulatory effects hAECs a potential therapy MS-like disease, EAE (experimental encephalomyelitis), mice. Using flow cytometry, phenotypic profile from different donors...
The immunomodulatory properties of human amnion epithelial cells (hAECs) have been previously described in several disease models. We reported on the ability hAECs to influence macrophage phenotype and chemotaxis. In this study, we aim elucidate contribution regulatory T (Tregs) polarisation downstream effects inflammation fibrosis a bleomycin model lung injury.Either CD45(+)/FoxP3(+) Tregs or CD45(+)/FoxP3 (-) non-Tregs were adoptively transferred into Rag1 (-/-) mice immediately prior...
Perinatal asphyxia is a significant cause of death or long-term neurodevelopmental impairment. Hypothermia, currently the only effective treatment, leads to modest improvements, but new therapeutic strategies are required. Umbilical cord blood (UCB) mononuclear cells have potent anti-inflammatory properties and may reduce neuropathology. This study examined whether autologous UCB were neuroprotective when administered newborn lambs at 12 h after birth asphyxia. At caesarean section, was...
Following microdiscectomy, discs generally fail to undergo spontaneous regeneration and patients may experience chronic low-back pain recurrent disc prolapse. In published studies, formulations of mesenchymal progenitor cells combined with pentosan polysulfate (MPCs+PPS) have been shown regenerate tissue in animal models, suggesting that this approach provide a useful adjunct microdiscectomy. The goal preclinical laboratory study was determine if the transplantation MPCs+PPS, embedded...
Importance Studies suggest that early neurodevelopmental assessments are beneficial for identifying cerebral palsy, yet their effectiveness in practical scenarios and ability to detect cognitive impairment limited. Objective To assess the of palsy other impairments, including severity, within a multidisciplinary clinic. Design, Setting, Participants This diagnostic study was conducted at Monash Children’s Hospital, Melbourne, Australia. were extremely preterm infants born less than 28 weeks’...
Blood-brain barrier (BBB) dysfunction and neuroinflammation are key mechanisms of brain injury. We performed a time-course study following neonatal hypoxia-ischemia (HI) to characterize these events. HI injury was induced in postnatal day 10 rats by single carotid artery ligation followed hypoxia (8% oxygen, 90 min). At 6, 12, 24, 72 h (h) post-HI, brains were collected assess neuropathology BBB dysfunction. A significant breakdown the observed group compared sham from 6 cortex hippocampus (
Mesenchymal stem/stromal cells (MSCs) can be isolated from most adult tissues and hold considerable promise for tissue regenerative therapies. Some of the potential advantages that MSCs have over other stem cell types include: (1) their relative ease isolation, culture expansion; (2) immunomodulatory properties; (3) they provide trophic support to injured tissues; (4) transduced by retroviral vectors at a high efficiency; (5) an ability home sites inflammation injury. Collectively these...
Cerebral palsy (CP) is a permanent motor disorder that results from brain injury and neuroinflammation during the perinatal period. Mesenchymal stromal cells (MSCs) have been explored as therapy in multiple adult neuroinflammatory conditions. Our study examined therapeutic benefits of intranasal delivery human umbilical cord tissue (UC) derived-MSCs rat model neonatal hypoxic-ischemic (HI) injury. To do this, HI was performed on postnatal day 10 Sprague-Dawley pups via ligation left carotid...
Background: Infants born preterm following exposure to in utero inflammation/chorioamnionitis are at high risk of brain injury and life-long neurological deficits. In this study, we assessed the efficacy early intervention umbilical cord blood (UCB) cell therapy a large animal model inflammation injury. We hypothesised that UCB treatment would be neuroprotective for subclinical fetal inflammation. Methods: Chronically instrumented sheep 0.65 gestation were administered lipopolysaccharide...
Abstract Background Neural stem cells (NSCs) have the potential to engraft and replace damaged brain tissue, repairing neonatal that causes cerebral palsy (CP). There are procedures could increase engraftment of NSCs may be critical for efficacy, but hold notable risks. Before clinical trials progress, it is important engage with CP community understand their opinions. The aim this study was determine acceptability NSC therapy in community. Methods Australian residents parents/carers those...
Severe brain injury (SBI), including severe intraventricular haemorrhage (sIVH) and cystic periventricular leukomalacia, poses significant challenges for preterm infants, yet recent data trends are limited.