Emily Trimm
A5025575399- Chromosomal and Genetic Variations
- Single-cell and spatial transcriptomics
- Microtubule and mitosis dynamics
- Evolution and Genetic Dynamics
- Genomics and Chromatin Dynamics
- Angiogenesis and VEGF in Cancer
- Reproductive Biology and Fertility
- interferon and immune responses
- Extracellular vesicles in disease
- Congenital heart defects research
- Immune cells in cancer
- CRISPR and Genetic Engineering
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Animal Genetics and Reproduction
- Cancer Genomics and Diagnostics
- T-cell and B-cell Immunology
- RNA and protein synthesis mechanisms
University of Pennsylvania
2017-2024
Stanford University
2021-2022
Molecular characterization of cell types using single-cell transcriptome sequencing is revolutionizing biology and enabling new insights into the physiology human organs. We created a reference atlas comprising nearly 500,000 cells from 24 different tissues organs, many same donor. This enabled molecular more than 400 types, their distribution across tissues, tissue-specific variation in gene expression. Using multiple single donor identification clonal T between mutation rate B cells,...
Genetic elements compete for transmission through meiosis, when haploid gametes are created from a diploid parent. Selfish can enhance their process known as meiotic drive. In female selfish drive by preferentially attaching to the egg side of spindle. This implies some asymmetry between two sides spindle, but molecular mechanisms underlying spindle unknown. Here we found that CDC42 signaling cell cortex regulated microtubule tyrosination induce and non-Mendelian segregation depended on this...
Abstract Cell-free RNA from liquid biopsies can be analyzed to determine disease tissue of origin. We extend this concept identify cell types origin using the Tabula Sapiens transcriptomic atlas as well individual atlases in combination with Human Protein Atlas consensus dataset. define type signature scores, which allow inference that contribute cell-free for a variety diseases.
[Figure: see text].
During meiosis, homologous chromosomes segregate so that alleles are transmitted equally to haploid gametes, following Mendel's Law of Segregation. However, some selfish genetic elements drive in meiosis distort the transmission ratio and increase their representation gametes. The established paradigms for fundamentally different female vs male meiosis. In typically kill gametes do not contain them. killing is predetermined, bias segregation single surviving gamete (i.e., egg animal...
Summary Asymmetric division in female meiosis creates selective pressure favoring selfish centromeres that bias their transmission to the egg. This centromere drive can explain paradoxical rapid evolution of both DNA and centromere-binding proteins despite conserved function. Here, we define a molecular pathway linking expanded histone phosphorylation recrui™ent microtubule destabilizing factors an intraspecific hybrid, leading detachment from spindle microtubules would direct them polar...
Genetic elements compete for transmission through meiosis, when haploid gametes are created from a diploid parent. Selfish can enhance their meiotic drive, in violation of Mendel’s Law Segregation. In female selfish drive by preferentially attaching to the egg side spindle, which implies some asymmetry between two sides but molecular mechanisms underlying spindle unknown. Here we show that CDC42 signaling cell cortex regulates microtubule tyrosination induce asymmetry, and non-Mendelian...
Asymmetric division in female meiosis creates selective pressure favoring selfish centromeres that bias their transmission to the egg. This centromere drive can explain paradoxical rapid evolution of both DNA and centromere-binding proteins despite conserved function. Here, we define a molecular pathway linking expanded histone phosphorylation recruitment microtubule destabilizing factors an intraspecific hybrid, leading detachment from spindle microtubules would direct them polar body. We...