A5067262509- Neuroblastoma Research and Treatments
- Single-cell and spatial transcriptomics
- Glioma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Chromatin Remodeling and Cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Congenital heart defects research
- Spine and Intervertebral Disc Pathology
- Virus-based gene therapy research
- Zebrafish Biomedical Research Applications
- CAR-T cell therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- Retinal Development and Disorders
- Adenosine and Purinergic Signaling
- Epigenetics and DNA Methylation
- Lung Cancer Research Studies
- Immunotherapy and Immune Responses
- Prostate Cancer Treatment and Research
- Virology and Viral Diseases
- Spinal Hematomas and Complications
- Invertebrate Immune Response Mechanisms
- Immune Cell Function and Interaction
- Pluripotent Stem Cells Research
- Cervical and Thoracic Myelopathy
- Fetal and Pediatric Neurological Disorders
Stanford University
2018-2025
California Institute for Regenerative Medicine
2021-2024
Palo Alto University
2018-2024
Cardiovascular Institute of the South
2022
University of California, Los Angeles
2013-2021
The developmental origin of blood-forming hematopoietic stem cells (HSCs) is a longstanding question. Here, our non-invasive genetic lineage tracing in mouse embryos pinpoints that artery endothelial generate HSCs. Arteries are transiently competent to HSCs for 2.5 days (∼E8.5–E11) but subsequently cease, delimiting narrow time frame HSC formation vivo. Guided by the arterial origins blood, we efficiently and rapidly differentiate human pluripotent (hPSCs) into posterior primitive streak,...
Prostate cancer is a heterogeneous disease composed of divergent molecular and histologic subtypes, including prostate adenocarcinoma (PrAd) neuroendocrine (NEPC). While PrAd the major histology in cancer, NEPC can evolve from as mechanism treatment resistance that involves transition an epithelial to neurosecretory phenotype. Cell surface markers are often associated with specific cell lineages differentiation states normal development cancer. Here, we show be broadly discriminated by...
Neuroendocrine carcinomas, such as neuroendocrine prostate cancer and small-cell lung cancer, commonly have a poor prognosis limited therapeutic options. We report that ubiquitin carboxy-terminal hydrolase L1 (UCHL1), deubiquitinating enzyme, is elevated in tissues plasma from patients with carcinomas. Loss of UCHL1 decreases tumor growth inhibits metastasis these malignancies. maintains differentiation promotes progression by regulating nucleoporin, POM121, p53. binds, deubiquitinates,...
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Basic science rodent model of bone morphogenetic protein-2 (BMP-2) soft-tissue inflammation.This study investigated the anti-inflammatory effect human dose equivalent (HDE) dexamethasone (DM) for treatment BMP-2-related inflammation in a and suggests an appropriate utilization clinical practice spine surgeons.BMP-2 is frequently used spinal surgery to augment fusion. Yet, side effects have been observed. DM decreases proinflammatory cytokine production cellular immune response. However, HDE...
Introduction Brain tumors are the most common solid malignancy and leading cause of cancer-related deaths in infants. Current epidemiological data is limited by low numbers reported cases. This study used a population-based approach with analysis contemporary historical survival curves to provide up-to-date prognostication. Methods Observational cohort was performed using Surveillance, Epidemiology End Results (SEER) database. Infants brain diagnosed from 1973 2013 were categorized tumor...
Undergraduate students participating in the UCLA Research Consortium for Functional Genomics (URCFG) have conducted a two-phased screen using RNA interference (RNAi) combination with fluorescent reporter proteins to identify genes important hematopoiesis Drosophila. This disrupted function of approximately 3500 and identified 137 candidate which loss leads observable changes hematopoietic development. Targeting RNAi maturing, progenitor, regulatory cell types key subsets that either limit or...
T cell-targeted therapies are commonly used to manage cell hyperactivity in autoimmune disorders, graft-versus-host diseases (GVHD), and transplant rejections. However, many patients experience significant side effects or inadequate responses current treatments, highlighting the urgent need for alternative strategies. In this study, we searched regulators of cells through proximity labeling with APEX2 detect proteins interacting CD8α, a coreceptor T-cell receptor (TCR). This screen revealed...
Abstract Neuroendocrine carcinomas, such as neuroendocrine prostate cancer (NEPC), small cell lung (SCLC), and neuroblastoma, share common histological features, including expression of markers, rapid relapse after treatment, poor prognosis. Due to the clinical outcome patients with there is a critical need identify new drivers, therapeutic targets, effective strategies for these malignancies. Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) protease that has dual function in regulating...
Management of brain tumors in infants has evolved over time, however, historical prognostication does not reflect current treatment and survival trends. This study used a population-based approach to differentiate contemporary from curves provide up-to-date prognostication. Observational cohort analysis was performed using the Surveillance, Epidemiology End Results (SEER) database. Infants with 1973-2013 were divided by tumor subtype (diffuse astrocytic/oligodendroglioma, choroid plexus,...