A5088129092- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Prostate Cancer Treatment and Research
- Blood Coagulation and Thrombosis Mechanisms
- Platelet Disorders and Treatments
- Hemophilia Treatment and Research
- Peptidase Inhibition and Analysis
- Cell Adhesion Molecules Research
- Cancer Genomics and Diagnostics
- Vitamin K Research Studies
- Renal cell carcinoma treatment
- Renal and related cancers
- Nitric Oxide and Endothelin Effects
- Hemostasis and retained surgical items
- Cellular Mechanics and Interactions
- Economic and Financial Impacts of Cancer
- Invertebrate Immune Response Mechanisms
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- HER2/EGFR in Cancer Research
- Health and Wellbeing Research
- Primary Care and Health Outcomes
- Viral Infectious Diseases and Gene Expression in Insects
- Radiopharmaceutical Chemistry and Applications
- Proteoglycans and glycosaminoglycans research
- Global Cancer Incidence and Screening
- Cancer survivorship and care
University of California, San Diego
2004-2025
UC San Diego Health System
2024
University of California, Los Angeles
2021
University of Illinois Urbana-Champaign
2007-2014
Illinois College
2007-2011
Abstract Purpose: Unfractionated heparin reduces metastasis in many murine models. Multiple mechanisms are proposed, particularly anticoagulation and/or inhibition of P-selectin and L-selectin. However, the doses used not clinically tolerable other heparins now commonly used. We studied by relevant levels various investigated structural basis for selectin differences. Experimental Design: Five approved were evaluated L-selectin binding to carcinoma cells. Pharmacokinetic studies determined...
Factor Va enhances the rate of prothrombin activation by factor Xa four to five orders magnitude. Production initiating levels from its precursor, V, is a critical event early in haemostasis, as V exhibits negligible cofactor activity. While thrombin most potent physiological back-activator first prothrombinase complexes require source prior generation. A recent study Whelihan et al. (J Thromb Haemost 2010; 8:1532-1539) identified XIa candidate for initial thrombin-independent although this...
Polyphosphates, linear polymers of inorganic phosphates linked by phosphoanhydride bonds, are widely present among organisms and play diverse roles in biology, including functioning as potent natural modulators the human blood clotting system. However, studies protein-polyphosphate interactions hampered a dearth methods for derivatizing polyphosphate or immobilizing it onto solid supports. We now report that EDAC (1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide) efficiently promotes covalent...
TPS302 Background: Advanced metastatic-castration-resistant prostate cancer (mCRPC) remains a lethal disease with limited treatment options. Cabozantinib is tyrosine kinase inhibitor (TKI) that targets VEGF, MET and AXL has demonstrated activity in patients mCRPC, particularly individuals bone liver metastases. Studies have anti-tumor of cabozantinib combined atezolizumab, programmed death ligand 1 targeting agent. In this study, we will investigate the efficacy combination nivolumab, (PD-1)...
449 Background: Clinical trials are the cornerstone for developing novel therapies and diagnostic tools. Due to advancements from clinical trials, median overall survival (OS) of patients with metastatic RCC has increased 4-fold in last 20 years (Lancet 2024). However, trial availability remains disproportionately concentrated high-income regions, limiting inclusion a diverse patient population (JCO CCI 2020). We aimed assess current state global RCC. Methods: Using National Trials database,...
321 Background: H/L pts with PCa are at an increased risk of developing ADT-related side effects. Diet and exercise can improve PCa-related outcomes, including reducing toxicities. However, little is known about individual perspectives on factors impacting engagement in health-promoting behaviors among men PCa. Methods: We developed a survey to examine sociodemographic characteristics, exercise/dietary habits, motivation for change, barriers participate lifestyle interventions. surveyed who...
26 Background: Black men are more likely to develop lethal prostate cancer (PCa) than non-Hispanic White men. It is not clear if this disparity related inherent biological causes or differences in social determinants of health including care access and utilization. We evaluated the impact prior primary provider (PCP) utilization on PCa outcomes its potential for addressing existing racial disparities. Methods: Our retrospective cohort study utilized SEER-Medicare database included patients...
5022 Background: Racial disparities are evident in PCa, with Black men experiencing a higher incidence and worse survival compared to NHW patients (pts). The molecular alterations that distinguish these groups remain incompletely characterized. Herein, we investigate the clinical-genomic features potentially contribute differences outcomes between pts PCa. Methods: Comprehensive next-generation sequencing of DNA (592-gene panel/whole exome) RNA (whole transcriptome) was performed at Caris...
Integrin-mediated cell adhesion is essential for development of multicellular organisms. In worms, flies, and vertebrates, talin forms a physical link between integrin cytoplasmic domains the actin cytoskeleton. Loss either integrins or leads to similar phenotypes. also key regulator affinity. We used ligand-mimetic Fab fragment, TWOW-1, assess talin's role in regulating Drosophila αPS2βPS Depletion cellular metabolic energy reduced TWOW-1 binding, suggesting affinity an active process as it...
Undergraduate students participating in the UCLA Research Consortium for Functional Genomics (URCFG) have conducted a two-phased screen using RNA interference (RNAi) combination with fluorescent reporter proteins to identify genes important hematopoiesis Drosophila. This disrupted function of approximately 3500 and identified 137 candidate which loss leads observable changes hematopoietic development. Targeting RNAi maturing, progenitor, regulatory cell types key subsets that either limit or...
Abstract Wnt (wingless-type) signaling pathway (WSP) alterations have been identified in patients with prostate cancer and are implicated disease progression hormonal resistance. In this study, we utilized a multi-institutional dataset to characterize molecular the canonical noncanonical WSPs cancer. Patients who underwent tissue-based genomic sequencing were investigated. Tumors somatic activating mutations CTNNB1 or RSPO2 inactivating either APC RNF43 characterized as having aberrant...
<div>Abstract<p>Wnt (wingless-type) signaling pathway (WSP) alterations have been identified in patients with prostate cancer and are implicated disease progression hormonal resistance. In this study, we utilized a multi-institutional dataset to characterize molecular the canonical noncanonical WSPs cancer. Patients who underwent tissue-based genomic sequencing were investigated. Tumors somatic activating mutations <i>CTNNB1</i> or <i>RSPO2</i>...