A5002023107- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Cervical and Thoracic Myelopathy
- Medical Imaging and Analysis
- Musculoskeletal pain and rehabilitation
- Scoliosis diagnosis and treatment
- Management of metastatic bone disease
- Connective tissue disorders research
- Orthopaedic implants and arthroplasty
- Pelvic and Acetabular Injuries
- Infectious Diseases and Tuberculosis
- Shoulder Injury and Treatment
- Oral and Maxillofacial Pathology
- Enhanced Recovery After Surgery
- Pregnancy-related medical research
- Orthopedic Infections and Treatments
- Spinal Hematomas and Complications
- Bone and Joint Diseases
- Anesthesia and Pain Management
- Aortic aneurysm repair treatments
- Veterinary Orthopedics and Neurology
- Bone Tissue Engineering Materials
- Bone Tumor Diagnosis and Treatments
- Neurofibromatosis and Schwannoma Cases
- Corneal Surgery and Treatments
Siriraj Hospital
2017-2025
Mahidol University
2014-2025
University of California, Los Angeles
2013-2015
Abstract Background Retinitis pigmentosa (RP) is a progressive inherited retinal disease with great interest for finding effective treatment modalities. Stem cell-based therapy one of the promising candidates. We aimed to investigate safety, feasibility, and short-term efficacy intravitreal injection bone marrow-derived mesenchymal stem cells (BM-MSCs) in participants advanced stage RP. Methods This non-randomized phase I clinical trial enrolled 14 participants, categorized into three groups...
Retrospective analysis of kinetic magnetic resonance images.To define the prevalence degenerative cervical spondylolisthesis in symptomatic patients and to analyze motion characteristics influence on spinal canal at affected level.When compared with lumbar spondylolisthesis, there are few studies evaluating not well defined.Four hundred sixty-eight underwent upright images neutral, flexion, extension positions. Segmental displacement intervertebral angles were measured 3 positions using...
OBJECT Most studies of Modic changes (MCs) have focused on investigating the relationship between MCs and lowback pain, whereas kinematic characteristics degenerative disc disease associated with are not well understood. To authors' knowledge, no previous study has reported kinematics MCs. The purpose this was to elucidate segmental motion disease. METHODS Four hundred fifty symptomatic patients underwent weight-bearing lumbar MRI in neutral, flexion, extension positions. Segmental...
Retrospective analysis of kinematic magnetic resonance images.To provide baseline data on the segmental angular and translational motion degenerated cervical spine by subtype kyphotic deformity to elucidate relationship between degree spinal cord compression.Kyphotic deformities are relatively common classified as either global or focal. Nevertheless, effects compression unknown.A total 1171 symptomatic patients (618 females, 553 males) underwent imaging in neutral, flexion, extension...
Retrospective analysis of kinematic magnetic resonance (MR) images.To elucidate the distribution and risk factors associated with missed dynamic stenosis in cervical spine.Motion spine is widely accepted to be spondylotic myelopathy; however, for spinal are not well understood.A total 435 symptomatic patients (2610 segments) obtained upright MR images neutral, flexion, extension postures. Spinal cord compression (SCC), spondylolisthesis, disc bulging, angular motion, translational...
Growth factors are of great potential in regenerative medicine. However, their clinical applications largely limited by the short vivo half-lives and narrow therapeutic window. Thus, a robust controlled release system remains an unmet medical need for growth-factor-based therapies. In this research, nanoscale (degradable protein nanocapsule) is established via situ polymerization on growth factor. The rate can be finely tuned engineering surface polymer composition. Improved outcomes...
Cross-sectional study.The aim of this study was to evaluate cervical disc degeneration on magnetic resonance imaging (MRI) in a large population symptomatic patients and provide baseline data the pattern order understand how spine ages.We performed cross-sectional 1059 who underwent upright MRI for neck pain with without neurological symptoms. A total 6354 discs from C2/3 C7/T1 were evaluated. Cervical evaluated T2-weighted graded into 4 categories (Grades 0-III). Positive defined as greater...
Intrathecal transplantation is a minimally invasive method for the delivery of stem cells, however, whether cells migrate from lumbar to injured cervical spinal cord has not been proved in humans. We describe an attempt track bone marrow-derived mesenchymal patient with chronic injury.A 33-year-old Thai man who sustained incomplete injury atlanto-axial subluxation was enrolled into pilot study aiming labeled superparamagnetic iron oxide nanoparticles, intrathecal injury. He had dependent on...
Retrospective cohort study with propensity-score-matched analysis. To compare the efficacy of vertebroplasty (VP) versus short-segment posterior instrumentation (SS) VP in patients osteoporotic vertebral fractures (OVFs). OVFs significantly affect aging population, causing pain, reduced mobility, and increased dependence. Treatment guidelines vary, a consensus on most effective approach remains unclear. best our knowledge, no previous report focused comparison alone SS VP. The included...
Study Design: Retrospective analysis of kinetic magnetic resonance images (kMRIs). Objective: (1) To analyze the changes seen on MRI related to disk degeneration and develop a new grading system for cervical degeneration. (2) evaluate reliability validity system. Summary Background Data: Few have studied relationship between with chronological order A few systems been reported; however, there problems subjectivity lack clear, reliable algorithm. Methods: total 300 intervertebral disks were...
Lumbar interbody fusion techniques treat degenerative lumbar diseases effectively. Minimally invasive lateral (LLIF) decreases soft tissue disruption and accelerates recovery better than standard open posterior (PLIF). However, the material cost of LLIF is high, especially in Thailand. The cost-effectiveness PLIF developing countries unclear. This study compared cost-utility clinical outcomes Thailand.Data from patients with spondylosis who underwent single-level between 2014 2020 were...
This study was an in vivo kinematic magnetic resonance imaging analysis of cervical spinal motion human subjects.The objective the to identify associations between disk degeneration subaxial spine and upper patients with general age-related spondylosis.The relationship occipital-atlantoaxial complex spondylosis decreased is not well understood.A total 446 symptomatic who had neck pain without neurogenic symptoms were included this study. Kinematic performed dynamic upright, weight-bearing...
Objective. To report a nationwide survey of the endoscopic spine surgeons across Thailand. Furthermore, will be focused on perspective experience, learning curve, motivations, and obstacles at beginning their practices. Materials Methods. The online consisting 16 items was distributed to who are performing surgery in Thailand via Google forms web-based questionnaire investigate participants’ demographics, backgrounds, experience surgery, obstacles, future perspectives. data recorded from...
Basic science rodent model of bone morphogenetic protein-2 (BMP-2) soft-tissue inflammation.This study investigated the anti-inflammatory effect human dose equivalent (HDE) dexamethasone (DM) for treatment BMP-2-related inflammation in a and suggests an appropriate utilization clinical practice spine surgeons.BMP-2 is frequently used spinal surgery to augment fusion. Yet, side effects have been observed. DM decreases proinflammatory cytokine production cellular immune response. However, HDE...
In Brief Study Design. Retrospective analysis using kinetic magnetic resonance imaging. Objective. To investigate relationships between vertebral endplate remodeling, Modic changes, disc degeneration, and lumbar segmental mobility. Summary of Background Data. Previous studies have shown that degeneration changes are associated with differences in spinal motion, however, the effects morphology on motion not been fully investigated. Methods. A total 420 patients underwent imaging 2100...
An optimal pedicle screw density for spinal deformity correction in adolescent idiopathic scoliosis (AIS) remains poorly defined. We compared radiographic correction, operative time, estimated blood loss, and implant cost among different patterns operatively treated AIS patients.A retrospective observational cohort study of patients who underwent posterior fusion using all-pedicle instrumentation was conducted from January 2012 to December 2018. All were categorized into three groups: the...
Abstract Introduction Chordomas are rare, locally aggressive tumors that often occur in the axial spine, especially sacrum. The treatment of chordomas located upper cervical spine is challenging. En bloc resection preferred surgical option for total tumor removal. Case presentation We report case a C2 chordoma 47-year-old Thai woman. She was treated with two-stage, anterior–posterior, spondylectomy titanium mesh cage reconstruction and radiotherapy. first stage involved posterior...
The purpose of this study was to examine the movement spinal cord and its relationship canal in patients with mild spondylosis using kinetic magnetic resonance imaging (kMRI).Weight-bearing, multiposition kMRI performed on symptomatic through a full range flexion-extension. A total 52 were selected based C2-C7 Cobb angle sagittal alignment: lordotic (from 30 45 degrees). We evaluated dynamic changes different parameters from flexion-extension: diameter (CD), (SCD), space available for cord,...
Abstract Study design Retrospective study. Objectives To perform effectiveness and economic analyses using data from a retrospective study of patients who underwent XLIF surgery tricalcium phosphate combined with iliac bone graft (TCP + IBG) or BMP-2 in Thailand. Methods Data were collected review the medical charts spine registry Siriraj Hospital, Bangkok, The divided into two groups IBG group group). Demographic, perioperative data, radiographic, clinical results, quality life related to...
Cross-sectional study.To evaluate lumbar disc degeneration (LDD) on magnetic resonance imaging (MRI) in symptomatic subjects to accumulate baseline data the pattern of degeneration.LDD plays an important role diagnosis and treatment low-back pain patients. Few studies have focused LDD understand how spine ages.This study included 1,095 patients (mean age, 44.29 years; range, 16-85 years) who underwent upright MRI. was graded into five categories (I-V). Positive defined as grade III or...