The purpose of this study was to compare the clinical outcomes and radiological changes 3- 4-level anterior cervical diskectomy fusion with stand-alone anchored spacers traditional plates. A total 51 consecutive patients spondylotic myelopathy who underwent or were divided into 2 groups: group (n=23) received B (n=28) an plate. Mean follow-up 14.6 months. Solid achieved in all at final follow-up. No significant difference existed between multilevel implants plate achieving symptomatic...

Abstract There is no definitive conclusion regarding the optimal timing for terminating propranolol treatment infantile hemangioma (IH). A total of 149 patients who underwent detailed color Doppler ultrasound examination were included in this study. The characteristics and all summarized analyzed. Patients divided into two groups according to lesion regression rate. Among patients, 38 assigned complete group, 111 partial group. age at which started, duration follow-up after discontinuation...

The growth and development of skeletal muscle require a series regulatory factors. MiRNA is non-coding RNA with length about 22 nt, which can inhibit the expression mRNA plays an important role in cells. miR-22-3p C2C12 cells porcine has been reported, but it not verified Hu sheep muscle. Through qPCR, CCK-8, EdU cell cycle studies, we found that overexpression inhibited proliferation (p < 0.01). results qPCR immunofluorescence showed promoted differentiation 0.01), while inhibiting were...

In order to investigate the effect of FecB on litter size and growth development traits Suhu meat sheep inheritance patterns between parents offspring in population. this experiment, 2241 from population were tested for using capillary electrophoresis. We combined lambing records 473 ewes, trait 881 at both birth weaning (2-month-old) stages, complete genealogical 643 lambs analysis distribution breeding population, its lambs, FecB. The results showed that there three genotypes namely AA...

Abstract Topical timolol and 595‐nm pulsed dye laser ( PDL ) are both widely used in the treatment of superficial infantile hemangiomas IH ). However, to date, there is no reliable study comparing therapeutic outcomes between two options. We designed present evaluate compare efficacy safety cream proliferating . Twenty‐one patients with were included study. Each lesion was divided into regions; one part treated 0.5% topical four times daily, other monthly Both treatments continued for 2–6...

Expanded polytetrafluoroethylene (ePTFE) is a widely used alloplast, but studies of augmentation the nasal tip and dorsum with ePTFE are lacking.To investigate whether attaching conchal cartilage as shield grafts at distal end graft can prevent extrusion use in achieve stable aesthetic outcome.A randomized clinical trial was performed from April 1, 2006, to October 31, 2008. Follow-up completed 2012 2017. The study conducted Department Plastic Reconstructive Surgery, Shanghai Ninth People's...

Uncovering genes associated with muscle growth and body size will benefit the molecular breeding of meat Hu sheep. HMGA2 has proven to be an important gene in mouse is various species. However, its roles sheep are still limited. Using myoblast as a cell model, overexpression significantly promoted proliferation, while interference expression inhibited indicated by qPCR, EdU, CCK-8 assays. Furthermore, dual-luciferase reporter system that region NC_056056.1: 154134300-154134882 (-618 -1200 bp...

Abstract Although infantile hemangiomas ( IH ) spontaneously involute, some leave more volumetric sequelae than others. Identifying predictors of such would provide a management reference for lesions and help achieve favorable outcomes. Our objective is to explore the correlation between residue remaining after involution its location identify other potential outcome predictors. All patients examined at our hospital from 2008 2011 were reviewed, both degree quantified obtained by comparing...

Background and Objectives Many types of lasers have been used to treat café‐au‐lait macules (CALMs) since the introduction selective photothermolysis theory. However, efficacy safety picosecond lasers, compared with those nanosecond not researched. To compare 755 nm laser (PS‐755 nm), Q‐switched (QS) Alexandrite (QS‐755 QS Nd:YAG 532 (QS‐532 nm) for treating CALMs. Study Design/Materials Methods Forty‐one patients received several treatments at 3‐month intervals. Lesions were divided into...

Previous genome-wide association studies (GWAS) have found that LAP3 may the potential function to impact sheep muscle development. In order further explore whether expression has an important role in development of embryonic myoblasts, we conducted spatiotemporal profile analysis at tissue and cellular level. Then used small interfering RNA eukaryotic recombinant vectors perform gain/loss-of-function LAP3. CCK-8 detection, EdU staining, flow cytometry were investigate knockdown or...

Dermal papilla cell (DPC), one of the key types during hair follicle development and regeneration, specifies size, shape cycling. It is also an important in vitro screening model for growth. Although some characteristics DPCs, such as agglutinative growth marker genes, have been studied mice humans, intrinsic properties ovine DPCs regulatory mechanism continued culture remained unknown. In this study, based on our previous single-cell transcriptome sequencing sheep lambskin, we verified...

This study aimed to identify the target genes of IGFBP3(insulin growth factor binding protein)protein and investigate its effects on proliferation differentiation Hu sheep skeletal muscle cells. IGFBP3 was an RNA-binding protein that regulates mRNA stability. Previous studies have reported promotes cells inhibits differentiation, but downstream bind it not been yet. We predicted through RNAct sequencing data, verified by qPCR RIP(RNA Immunoprecipitation)experiments, demonstrated GNAI2(G...

Congenital melanocytic nevi (CMN) that occur on the eyelid and periorbital region cause cosmetic disfiguring. Laser treatment has aroused interest as an alternative method, resurfacing lasers have shown promising results.This study aimed to evaluate efficacy safety of carbon dioxide laser erbium:yttrium aluminum garnet treat CMN region.Twenty patients with were included in this treated either CO2 or laser. Clinical outcomes evaluated by visual assessment L*a*b* color space evaluation at...

Purpose: The aim of this study is to compare the short-term and pathological outcomes TPLRC (Three-port laparoscopic right hemicolectomy) FPLRC (Five-port hemicolectomy), using propensity score matching analysis. Methods: One hundred sixty-eight patients who accepted hemicolectomy with either three ports or five from January 2013 October 2017 were non-randomly selected analyzed retrospectively. Propensity model was used eliminate patients' selection bias between two groups. Results: A total...

Previously, NCAPG was identified as a candidate gene associated with sheep growth traits. This study aimed to investigate the direct role of in regulating myogenesis embryonic myoblast cells and association between single-nucleotide polymorphisms (SNPs) its promoter region The function proliferation differentiation detected after small interfering RNAs (siRNAs) knocked down expression NCAPG. Cell using CCK-8 assay, EdU flow cytometry cell cycle analysis. via immunofluorescence quantification...

This study aims to analyze the whole genome sequencing of E. coli F17 in antagonistic and susceptible Hu sheep lambs. The objective is investigate critical mutation loci understand genetic mechanism resistance at level. Antagonist venous blood samples were collected from lambs for association analysis. A total 466 genes with significant SNPs (p &lt; 1.0 × 10−3) found. GO KEGG enrichment analysis protein interaction network performed on these genes, preliminary investigations showed that...

The repair of facial skin and soft tissue defects remains a clinical challenge. author introduced novel "table tennis racquet" random flap for wound after cancer excision discussed its survival mechanisms.

Background: Osteoarthritis (OA) and psychiatric disorders are prevalent conditions that frequently co-occur, suggesting potential shared genetic underpinnings. However, the extent of correlations causal relationships between these remains largely unknown.Methods: We performed cross-trait correlation analyses using genome-wide association study (GWAS) summary statistics for OA eight disorders. identified risk loci genes through pleiotropy analysis functional annotation. Bidirectional...

Intralesional injection is a common method among various therapeutic choices for the treatment of Infantile Hemangiomas. This article reviews clinical application intralesional injections infantile hemangiomas, discusses indications and evaluates safety efficacy different injected drugs. Key words: Infantile Hemangioma; Injection; Corticosteroid; Bleomycin; Pingyangmycin; Propranolol; Polidocanol