A5038804707- Nanoparticle-Based Drug Delivery
- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Graphene and Nanomaterials Applications
- Barrier Structure and Function Studies
- Tissue Engineering and Regenerative Medicine
- X-ray Diffraction in Crystallography
- Extracellular vesicles in disease
- Hydrogels: synthesis, properties, applications
- Hemostasis and retained surgical items
- Bone Tissue Engineering Materials
- Wound Healing and Treatments
- Periodontal Regeneration and Treatments
- Photodynamic Therapy Research Studies
- Advanced Cellulose Research Studies
- Metal-Organic Frameworks: Synthesis and Applications
- Crystallization and Solubility Studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Additive Manufacturing and 3D Printing Technologies
- Herpesvirus Infections and Treatments
- Electrochemical sensors and biosensors
- Connective tissue disorders research
Universidade Nova de Lisboa
2021-2025
Florida Agricultural and Mechanical University
2024
University of Tennessee Health Science Center
2024
University at Buffalo, State University of New York
2024
Faculdades Oswaldo Cruz
2024
Universidade Estadual de Montes Claros
2024
Population Council
2024
Universitario Francisco de Asís
2024
Universidade de Franca
2024
University of Minho
2017-2021
Photodynamic therapy (PDT), an emergent noninvasive cancer treatment, is largely dependent on the presence of efficient photosensitizers (PSs) and a sufficient oxygen supply. However, therapeutic efficacy PSs greatly compromised by poor solubility, aggregation tendency, depletion within solid tumors during PDT in hypoxic microenvironments. Despite potential PS-based metal–organic frameworks (MOFs), addressing hypoxia remains challenging. Boron dipyrromethene (BODIPY) chromophores, with...
Nanoparticle formulations blending optical imaging contrast agents and therapeutics have been a cornerstone of preclinical theranostic applications. However, nanoparticle-based theranostics clinical translation faces challenges on reproducibility, brightness, photostability, biocompatibility, selective tumor targeting penetration. In this study, we integrate multimodal within cancer cell-derived nanovesicles, leading to biomimetic bright optotheranostics for monitoring metastasis. Upon NIR...
Abstract Despite improvements in cancer survival rates, metastatic and surgery‐resistant cancers, such as pancreatic cancer, remain challenging, with poor prognoses limited treatment options. Enhancing drug bioavailability tumors, while minimizing off‐target effects, is crucial. Metal–organic frameworks (MOFs) have emerged promising delivery vehicles owing to their high loading capacity, biocompatibility, functional tunability. However, the vast chemical diversity of MOFs complicates...
Injectable hydrogels are particularly interesting for applications in minimally invasive tissue engineering and regenerative medicine strategies. However, the typical isotropic microstructure of these biomaterials limits their potential regeneration ordered tissues. In present work, we decorated rod-shaped cellulose nanocrystals with magnetic nanoparticles coated polydopamine polyethylene glycol polymer brushes to obtain chemical colloidal stable nanoparticles. Then, (0.1–0.5 wt %) were...
Three-dimensional (3D) bioprinting holds the promise to fabricate tissue and organ substitutes for regenerative medicine. However, lack of bioactive inks support functional living constructs is one main limitations hindering progress this technology. In study, a biofunctional human-based nanocomposite bioink (HUink) composed platelet lysate hydrogels reinforced by cellulose nanocrystals reported. When combined with suspended technologies, HUink allows biofabrication 3D freeform high...
The currently used hemostatic agents are highly effective in stopping hemorrhages but have a limited role the modulation of wound-healing environment. Herein, we propose an intrinsically bioactive cryogel based on platelet lysate (PL) and aldehyde-functionalized cellulose nanocrystals (a-CNCs). PL has attracted great attention as inexpensive milieu therapeutically relevant proteins; however, its application agent exhibits serious constraints (e.g., structural integrity short shelf-life)....
Injectable human-based nanocomposite hydrogels enable the modulation of multiple parameters physical and biological 3D cell microenvironment to guide fate.
Bioinspired cell-membrane-camouflaged nanohybrids have been proposed to enhance tumor targeting by harnessing their immune escape and self-recognition abilities. In this study, we introduce cancer-cell-derived membrane nanovesicles (CCMVs) integrated with gold nanorods (AuVNRs) in addition therapeutic imaging cargos such as doxorubicin indocyanine green. This approach enhances targeted enables synergistic chemo-phototherapeutics for solid tumors. CCMVs demonstrate significant penetration...
Abstract Metallic implants are widely used in diverse clinical applications to aid recovery from lesions or replace native hard tissues. However, the lack of integration metallic surfaces with soft tissue interfaces causes occurrence biomaterial‐associated infections, which can trigger a complicated inflammatory response and, ultimately, implant failure. Here, multifunctional surface showing nanoscale anisotropy, based on controlled deposition cellulose nanocrystals (CNC), and biological...
The use of miniaturized probes opens a new dimension in the analysis (bio)chemical processes, enabling possibility to perform measurements with local resolution. In addition, multiparametric are highly valuable for holistic understanding investigated process. Therefore, different strategies have been suggested simultaneous various parameters. Electroanalytical methods powerful strategy this direction. However, they mainly restricted coupling concurrent independent probes. Here, we present an...