A5102985021- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Cervical Cancer and HPV Research
- Advanced Breast Cancer Therapies
- DNA Repair Mechanisms
- Enzyme function and inhibition
- Plant tissue culture and regeneration
- Health Systems, Economic Evaluations, Quality of Life
- PARP inhibition in cancer therapy
- Neuroinflammation and Neurodegeneration Mechanisms
- Immunotherapy and Immune Responses
- Oral Health Pathology and Treatment
- Plant responses to water stress
- Respiratory viral infections research
- Neurological Disease Mechanisms and Treatments
- Pediatric health and respiratory diseases
- Economic and Financial Impacts of Cancer
- Medical Device Sterilization and Disinfection
- Respiratory and Cough-Related Research
- Immune Response and Inflammation
- Head and Neck Cancer Studies
- Barrier Structure and Function Studies
- Molecular Biology Techniques and Applications
Era's Lucknow Medical College and Hospital
2020-2024
Integral University
2022
Objectives Cervical cancer (CC) is one of the most destructive disease caused by persistent HPV infection which affects women worldwide, especially in developing countries. The genetic basis host immune response cytokine function has been shown to influence CC susceptibility. Studies have demonstrated that IL-10 gene polymorphism associated with numerous malignancies, but context results were inconclusive. Though, aim our study investigate association between -1082A/G and -819C/T promoter...
Backgrounds: Cervical cancer (CC) is one of the leading cause death in women worldwide, HPV infection major risk factor disease development, 0and however other such as chemical carcinogens, genetic susceptibility and altered immune system are also a progression. In light above statement we studied base excision repair pathway (BER). Methods: We identified association Single Nucleotide polymorphisms DNA genes XRCC1 (Arg194Trp, Arg399G,) APE-1Asp/148Glu to cervical North Indian population. our...
Background and Objective: Cervical cancer is one of the most frequent neoplastic disorders affecting women, with about half a million new cases diagnosed globally each year. Reduced DNA repair capacity (DRC) linked to an increased risk cancer, particularly cervical cancer. gene polymorphisms may play role in genomic instability carcinogenesis. number factors that have been verified. The goal this study was compare genotypes genes XRCC1-194, XRCC1-280, XRCC1-399, XRCC3-241 distinct...
Abstract To target DNA repair vulnerabilities in cancer, we discovered nanomolar potent, selective, low molecular weight (MW), allosteric inhibitors of the polymerase function Polθ, including ART558. ART558 inhibits major Polθ-mediated process, Theta-Mediated End Joining (TMEJ), without targeting Non-Homologous Joining. Moreover, show that exposure to can elicit damage and synthetic lethality BRCA1- or BRCA2-mutant tumor cells enhances effects a PARP inhibitor. Genetic perturbation screening...
Various researches have shown that Cluster of Differentiation 44 (CD44) is one the valued markers. As it plays an important role in tumor growth and metastasis but studies also suggest as a cancer stem cell (CSC) marker oral (OC). Therefore, we aimed to explore association between expression CD44 clinicopathological characteristics along with OC prognosis.We conducted literature search through PubMed database (till October 22, 2020) determine evaluate clinical prognostic significanceof...
Supplementary Data from A Novel Small-Molecule Inhibitor of Protein Kinase D Blocks Pancreatic Cancer Growth <i>In vitro</i> and vivo</i>
Supplementary Data from A Novel Small-Molecule Inhibitor of Protein Kinase D Blocks Pancreatic Cancer Growth <i>In vitro</i> and vivo</i>
<div>Abstract<p>Protein kinase D (PKD) family members are increasingly implicated in multiple normal and abnormal biological functions, including signaling pathways that promote mitogenesis pancreatic cancer. However, nothing is known about the effects of targeting PKD Our inhibitor discovery program identified CRT0066101 as a specific all isoforms. The aim our study was to determine Initially, we showed autophosphorylated PKD1 PKD2 (activated PKD1/2) significantly upregulated...
<div>Abstract<p>Protein kinase D (PKD) family members are increasingly implicated in multiple normal and abnormal biological functions, including signaling pathways that promote mitogenesis pancreatic cancer. However, nothing is known about the effects of targeting PKD Our inhibitor discovery program identified CRT0066101 as a specific all isoforms. The aim our study was to determine Initially, we showed autophosphorylated PKD1 PKD2 (activated PKD1/2) significantly upregulated...