A5050133106- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Peripheral Neuropathies and Disorders
- Viral Infections and Immunology Research
- Ear Surgery and Otitis Media
- Hearing, Cochlea, Tinnitus, Genetics
- HIV Research and Treatment
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Vestibular and auditory disorders
- Hereditary Neurological Disorders
- Hematological disorders and diagnostics
- Blood groups and transfusion
- Cardiac Structural Anomalies and Repair
- Tuberculosis Research and Epidemiology
- Acute Ischemic Stroke Management
- Heparin-Induced Thrombocytopenia and Thrombosis
- Platelet Disorders and Treatments
- Antimicrobial Resistance in Staphylococcus
- Sphingolipid Metabolism and Signaling
- Infective Endocarditis Diagnosis and Management
- Congenital Diaphragmatic Hernia Studies
- Child and Adolescent Health
- Inflammasome and immune disorders
- Viral Infectious Diseases and Gene Expression in Insects
Murdoch Children's Research Institute
2021-2025
The University of Melbourne
2021-2025
Royal Children's Hospital
2022-2025
Melbourne Health
2023-2024
University of Minnesota
2023
The University of Sydney
2021-2023
Ohio Northern University
2023
Despite long-term antiretroviral therapy (ART), HIV-1 persists within a reservoir of CD4+ T cells that contribute to viral rebound if treatment is interrupted. Identifying the cellular populations and understanding mechanisms persistence are necessary achieve an effective cure. In this regard, through Full-Length Individual Proviral Sequencing, we observed proviral landscape was different changed with time on ART across naive memory cell subsets isolated from 24 participants. We found...
Pain associated with bone cancer remains poorly managed, and chemotherapeutic drugs used to treat usually increase pain. The discovery of dual-acting that reduce produce analgesia is an optimal approach. mechanisms underlying pain involve interactions between cells nociceptive neurons. We demonstrated fibrosarcoma express high levels autotaxin (ATX), the enzyme synthetizing lysophosphatidic acid (LPA). Lysophosphatidic increased proliferation in vitro. also a pain-signaling molecule, which...
Evidence regarding audiovestibular adverse events post COVID-19 vaccination to date has been inconclusive a potential association. This study aimed determine if there was an increase in following South-eastern Australia during January 2021–March 2023. A multi-data source approach applied. First, retrospective observational analysis of spontaneous reports statewide vaccine safety surveillance service, SAEFVIC. Second, self-controlled case series using general practice data collected via the...
Importance COVID-19 mRNA vaccine-associated myocarditis has previously been described; however specific features in the adolescent population are currently not well understood. Objective To describe adverse events following immunisation reported any vaccines Victoria, Australia. Design Statewide, population-based study. Setting Surveillance of Adverse Events Following Vaccination Community (SAEFVIC) is vaccine-safety service for Participants All SAEFVIC reports and myopericarditis...
Introduction: Pediatric stroke is a rare event associated with high morbidity and reduced quality of life. While the causes pediatric are often unclear, recent infection thought to be significant factor. We sought determine incidence in Australia whether infections vaccinations stroke. Methods: A population-based observational study was undertaken using routinely collected linked data from Vaccine Safety Health Link. The cohort comprised all children, aged 28 days 18 years, admitted hospital...
To determine whether hepatitis B virus (HBV) vaccination of extremely preterm infants (defined in our study as < 29 weeks gestation) within 24 hours birth (birth-dose) increases the risk developing bronchopulmonary dysplasia. Using data from Australia, we conducted a population linkage using Victorian Vaccine Safety Health Link. This platform links state-wide immunization and health outcomes Perinatal Data Collection Admitted Episodes Dataset. Our retrospective cohort included all born alive...
Human immunodeficiency virus (HIV) persists in cells despite antiretroviral therapy; however, the influence of cellular mechanisms such as activation, differentiation, and proliferation upon distribution proviruses over time is unclear. To address this, we used full-length sequencing to examine within memory CD4+ T-cell subsets longitudinally 8 participants. Over time, odds identifying a provirus increased effector decreased transitional cells. In all subsets, more activated...
Abstract Objectives To describe myocarditis as an adverse event after coronavirus disease 2019 (COVID‐19) vaccination, including a detailed description of clinical phenotypes and diagnostic test results differences by age, sex, degree troponin level elevation. Study design Retrospective cross‐sectional study. Setting, participants Cases suspected following the administration COVID‐19 vaccine in Victoria during 22 February 2021 – 30 September 2022 reported to Surveillance Adverse Events...
An EMS-based forward genetic screen was conducted in an apoptotic null background to identify aberrations that contribute regulation of cell growth
ABSTRACT Importance Evidence regarding audiovestibular adverse events post COVID-19 vaccination to date has been inconclusive a potential etiological association. This study used multi-data source approach assess incidence of these following vaccination. Objective To determine if there was an increase in South-eastern Australia during January 2021 – March 2023. Design Retrospective observational analysis spontaneous reports statewide vaccine safety surveillance service, SAEFVIC, as well...
Guillain–Barré syndrome (GBS) is an adverse event of special interest (AESI) for surveillance systems monitoring events following immunisation (AEFI) with COVID-19 vaccines. Emerging data support a temporal association between GBS and adenovirus-vector We present case series reports submitted February November 2021 to our enhanced spontaneous system (SAEFVIC) in Victoria, Australia, vaccination either the vaccine Vaxzevria ChadOx1-S (AstraZeneca) or mRNA (Comirnaty BNT162b2 [Pfizer-BioNTech]...
Abstract Focus of Presentation ‘Cluster Tracker’ is an automated tool for spatial cluster detection notifiable disease data collected by the Department Health (DH), Victoria. The combines R statistical software and a SaTScan algorithm (prospective space-time permutation scan statistic) to detect case clusters in Victoria presently implemented salmonellosis (categorised type and/or MLVA). objective conduct initial screening improve prioritisation cases epidemiological investigation. Findings...