A5068298084- Bone Metabolism and Diseases
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Natural product bioactivities and synthesis
- Gallbladder and Bile Duct Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Endometrial and Cervical Cancer Treatments
- Bone health and osteoporosis research
- PI3K/AKT/mTOR signaling in cancer
- RNA modifications and cancer
- Cervical Cancer and HPV Research
- T-cell and B-cell Immunology
- Lysosomal Storage Disorders Research
- Phytochemistry and Biological Activities
- Inflammatory mediators and NSAID effects
- Traditional Chinese Medicine Analysis
- Immune Cell Function and Interaction
- Carbohydrate Chemistry and Synthesis
- Diabetes Treatment and Management
- Kruppel-like factors research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenetic and Muscular Disorders Research
- Cytokine Signaling Pathways and Interactions
Shaanxi University of Chinese Medicine
2008-2024
Hunan Normal University
2019-2024
Hunan Provincial People's Hospital
2009-2024
Guangdong Academy of Medical Sciences
2024
Guangdong Provincial People's Hospital
2024
University of Minnesota
2018-2024
Zhejiang Sci-Tech University
2019-2024
Shanghai University of Traditional Chinese Medicine
2023
XinHua Hospital
2021
Changsha Normal University
2021
Although the transcription factor Krüppel-like 5 (KLF5) plays important roles in both inflammation and cancer, mechanism by which this promotes cervical carcinogenesis remains unclear. In study, we demonstrated a potential role for tumour necrosis receptor superfamily member 11a (TNFRSF11a), corresponding gene of is direct binding target KLF5, cell proliferation invasiveness. Coexpression KLF5 TNFRSF11a correlated significantly with tumorigenesis tissues (P < 0.05) manipulation expression...
Multiple sclerosis (MS) is a chronic neurological disease of unknown etiology, but genetic basis for the undisputed. We have reported that CD24 required pathogenicity autoreactive T cells in experimental autoimmune encephalomyelitis, mouse model MS. Here we investigate contribution to MS by studying single-nucleotide polymorphism ORF among 242 patients and 207 population controls. This results replacement alanine ( ) with valine v mature protein. found v/v renders >2-fold increase...
Plant peroxidases were found to play an important role in plant physiology such as the metabolism and transformation of small complexes. In present research, a novel Momordica charantia peroxidase (MCP) from fruits was purified electrophoretic homogeneity by combining consecutive treatment ammonium sulfate fractionation, ion exchange chromatography on DEAE-Sepharose FF, affinity concanavalin A (Con A) Sepharose gel filtration Sephadex G-150. The physical chemical characters MCP also...
Purpose: To investigate inhibitory effect of Astragalus polysaccharide (APS) on osteoporosis in ovariectomized rats by regulating FoxO3a/Wnt2 signaling pathway. Methods: Postmenopausal (PMOP) animal model was developed excising the bilateral ovaries rats. The were administered with APS (200 mg/kg, 400 800 mg/kg) intragastric administration once daily for 12 weeks. Bone density, bone metabolism index and oxidative stress measured all groups. Furthermore, regulation FoxO3a / Wnt2 pathway...
Background: Estrogen-related receptor-α (ESRRA) is an orphan nuclear receptor, expressing at high level in exuberant metabolism organs and acting as transcription factor.High expression was found many malignances but no research done gastric cancer (GC), where lipid disorder common.Methods: Kaplan-Meier plot utilized to find the relationship between ESRRA patients' prognoses.The of measured by real-time PCR.The protein levels were tested with western-blot immunohistochemistry. Cell cycle...
Objective: To explore the relationship between methylation of interferon gamma (IFN-γ) gene and tumorigenesis in cervical cancer tissues, biopsy specimens intraepithelial neoplasia (CIN) (I-III) patients as well normal controls were collected analyzed. Methods: The IFN-γ was verified by using methylation-specific PCR DNA sequencing analysis expression levels mRNA detected quantitative real-time reverse transcriptase-polymerase chain reaction (qRT-PCR). Results: rates significantly higher...
Purpose To study effects of Rehmannia glutinosa polysaccharides (RGP) on bone tissue structure and skeletal muscle atrophy in rats with disuse. Methods A rat model disuse osteoporosis combined was established by removing the bilateral ovaries fixing their hind limbs for a long time. Forty SD were administered intragastrically 12 weeks. The histomorphometry parameters level oxidative stress measured. In addition, changes F-box (MAFbx), RING-finger protein-1 (MuRF1), forkhead box O1 (FOXO1)...
Abstract Background and Objectives The prognosis of biliary tract cancers (BTC) after radical resection is still unsatisfactory. However, the clinical value adjuvant therapy remains controversial. This retrospective study aimed to evaluate chemotherapy chemoimmunotherapy in patients with BTC resection. Methods Data from who underwent were retrospectively obtained Hunan Provincial People’s Hospital between January 2020 July 2024. Patients divided into observation group, group according...
Emodin is a natural anthraquinone derivative with numerous beneficial effects, including antioxidant properties, anti-tumor activities, and protecting the nerves. Zinc-induced neurotoxicity plays crucial role in pathogenesis of vascular dementia (VD) Parkinson's disease (PD). Here, protective activity emodin inhibiting zinc-induced its molecular mechanisms such as cellular Zn2+ influx gene expression were examined using human neuroblastoma cells (SH-SY5Y cells). Our findings showed that...
Leptin is an adipokine minimally known for its activities or underlying mechanisms in cholangiocarcinoma. The present study explored the effects of leptin on epithelial‑mesenchymal transition (EMT) and pro‑angiogenic capability cholangiocarcinoma cells, investigated mechanisms. Cholangiocarcinoma cells were treated with leptin, their migration invasion rates using Transwell assays. Furthermore, conditioned medium was collected from following treatment applied to human umbilical vein...
Rehmanniae Radix Preparata (RRP) can effectively improve the symptoms of osteoporosis, but its molecular mechanism for treating osteoporosis is still unclear. The objective this study to investigate anti-osteoporosis mechanisms RRP through network pharmacology. overlapping targets and were screened out using online platforms. A visual diagram PPI was constructed analyzed by Cytoscape 3.7.2 software. Molecular docking used evaluate binding activity ligands receptors, some key genes verified...
Everolimus (RAD001) is a mTOR inhibitor and widely used for the treatment of gastric cancer (GC). Evidence suggests that Rhein has anticancer effect on GC. But synergistic mechanism RAD001 combination GC not clear. The current study aims to clarify in treatment. We found dose-dependently repressed MGC-803 cell viability (50% inhibition concentration (IC50) value = 94.26 μM). (80 μM) significantly suppressed proliferation invasion. cells (IC50 45.41 nM). viability, invasion, compared...
Liver fibrosis and cirrhosis is associated with the prognosis of patients hepatocellular carcinoma (HCC) after treatment. The γ-glutamyl transpeptidase to platelet ratio (GPR) reported predict significant liver cirrhosis. aim this study was investigate predictive value preoperative GPR on recurrence survival HCC who underwent curative hepatectomy. A retrospective review demographics, medical records, hepatitis B virus (HBV)–related performed. Overall (OS) disease-free (DFS) were evaluated...
Cholangiocarcinoma (CCA) is a highly aggressive and malignant tumor. In this study, the effect molecular mechanism of nuclear enriched abundant transcript 1 (NEAT1) in CCA were elucidated. The expressions NEAT1, microRNA-186-5p (miR-186-5p), PTP4A1 measured by quantitative real-time PCR. protein levels Western blotting. Kaplan-Meier analysis was performed to create survival curves. interactions between miR-186-5p, assessed through dual luciferase reporter assay. Additionally, cell...
Liver cancer is a serious global health problem and associated with poor spiritual health. Bibliotherapy beneficial in improving outcomes patients, yet there lack of empirical evidence its effect on the liver patients China. The study aimed to investigate effects bibliotherapy based Chinese traditional culture This was approved by Ethics Committee Hunan Normal University School Medicine registered Clinical Trial Registry registration (No: 2021260), which June 30th 2021.A total 60 were...
This study is aimed at investigating the feasibility and safety of laparoscopic radical resection for treating type III IV hilar cholangiocarcinoma (III/IV Hilar C). Six patients with III/IV C were enrolled in our hospital. All underwent total surgery, including basic surgery (laparoscopic gallbladder, bile duct, common duct hepatoduodenal ligament lymph node dissection) combined left hepatic caudate lobe resection/portal resection. The tumor size, operation time, intraoperative blood loss,...