A5039425833- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Lysosomal Storage Disorders Research
- Telomeres, Telomerase, and Senescence
- Animal Virus Infections Studies
- Genetics, Aging, and Longevity in Model Organisms
- Genetics and Neurodevelopmental Disorders
- Biomedical and Engineering Education
- RNA and protein synthesis mechanisms
- Plant and animal studies
- Parkinson's Disease Mechanisms and Treatments
- CRISPR and Genetic Engineering
- Bacteriophages and microbial interactions
- COVID-19 epidemiological studies
- Nuclear Receptors and Signaling
- RNA regulation and disease
- Inflammasome and immune disorders
- Immune responses and vaccinations
- vaccines and immunoinformatics approaches
- Pluripotent Stem Cells Research
- Pancreatic function and diabetes
- Epigenetics and DNA Methylation
- Plant Virus Research Studies
- RNA Research and Splicing
Baylor College of Medicine
2023-2024
University of Nottingham
2021-2022
Queen's Medical Centre
2021-2022
University of Sheffield
2021
Rockefeller University
2018-2019
Wellesley College
2018
Abstract Idiopathic Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in substantia nigra pars compacta, which associated with neuroinflammation and reactive gliosis. The underlying cause PD concurrent are not well understood. In this study, we utilize human murine neuronal lines, stem cell‐derived neurons, mice to demonstrate that three previously identified genetic risk factors for PD, namely SATB1, MIR22HG, GBA, components a single gene regulatory pathway. Our...
Recent studies have emphasized the significance of biomolecular condensates in modulating gene expression through RNA processing and translational control. However, functional roles cell fate specification remains poorly understood. Here, we profiled coding non-coding transcriptome within intact condensates, specifically P-bodies, diverse developmental contexts, spanning multiple vertebrate species. Our analyses revealed conserved, type-specific sequestration untranslated RNAs encoding key...
Abstract Cellular senescence is a mechanism used by mitotic cells to prevent uncontrolled cell division. As senescent persist in tissues, they cause local inflammation and are harmful surrounding cells, contributing aging. Generally, neurodegenerative diseases, such as Parkinson‘s, disorders of The contribution cellular neurodegeneration still unclear. SATB1 DNA binding protein associated with Parkinson’s disease. We report that prevents post-mitotic dopaminergic neurons. Loss causes...
Idiopathic Parkinson's Disease (PD) is characterized by the loss of dopaminergic neurons in substantia nigra pars compacta, which associated with neuroinflammation and reactive gliosis. The underlying cause PD concurrent are not well understood. In this study, we utilized human murine neuronal lines, stem cell-derived neurons, mice to demonstrate that three previously identified genetic risk factors for PD, namely SATB1, MIR22HG, GBA, components a single gene regulatory pathway. Our findings...
Background: Diabetic retinopathy (DR) is the most serious ocular complication associated with T2DM, which a metabolic syndrome (MS), and one of leading causes secondary blindness.Although animal models DR have helped to advance in knowledge this disease, these some limitations reproduce completely early stage where take place beginning neuronal vascular alteration.Objetive: Analyze stages MS, markers retinal integrity functionality explore details mechanisms action that command...