A5087826176- Genetics, Aging, and Longevity in Model Organisms
- Telomeres, Telomerase, and Senescence
- Lysosomal Storage Disorders Research
- Genetics and Neurodevelopmental Disorders
- Parkinson's Disease Mechanisms and Treatments
- Regulation of Appetite and Obesity
- Pancreatic function and diabetes
- Epigenetics and DNA Methylation
- Olfactory and Sensory Function Studies
- Nuclear Receptors and Signaling
- RNA regulation and disease
- Biochemical Analysis and Sensing Techniques
Stony Brook School
2023-2024
Stony Brook University
2023-2024
Rockefeller University
2018-2019
Monell Chemical Senses Center
2016
Abstract Idiopathic Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in substantia nigra pars compacta, which associated with neuroinflammation and reactive gliosis. The underlying cause PD concurrent are not well understood. In this study, we utilize human murine neuronal lines, stem cell‐derived neurons, mice to demonstrate that three previously identified genetic risk factors for PD, namely SATB1, MIR22HG, GBA, components a single gene regulatory pathway. Our...
Abstract Cellular senescence is a mechanism used by mitotic cells to prevent uncontrolled cell division. As senescent persist in tissues, they cause local inflammation and are harmful surrounding cells, contributing aging. Generally, neurodegenerative diseases, such as Parkinson‘s, disorders of The contribution cellular neurodegeneration still unclear. SATB1 DNA binding protein associated with Parkinson’s disease. We report that prevents post-mitotic dopaminergic neurons. Loss causes...
Idiopathic Parkinson's Disease (PD) is characterized by the loss of dopaminergic neurons in substantia nigra pars compacta, which associated with neuroinflammation and reactive gliosis. The underlying cause PD concurrent are not well understood. In this study, we utilized human murine neuronal lines, stem cell-derived neurons, mice to demonstrate that three previously identified genetic risk factors for PD, namely SATB1, MIR22HG, GBA, components a single gene regulatory pathway. Our findings...