A5101657683- Gastroesophageal reflux and treatments
- Helicobacter pylori-related gastroenterology studies
- Corneal Surgery and Treatments
- Diabetes Treatment and Management
- Potassium and Related Disorders
- Pharmaceutical studies and practices
- Epilepsy research and treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Lipoproteins and Cardiovascular Health
- Advancements in PLL and VCO Technologies
- Scoliosis diagnosis and treatment
- Gastrointestinal motility and disorders
- Gut microbiota and health
- Ocular Surface and Contact Lens
- Corneal surgery and disorders
- Inflammatory mediators and NSAID effects
- Anesthesia and Sedative Agents
- Glaucoma and retinal disorders
- Semiconductor materials and devices
- Ocular Diseases and Behçet’s Syndrome
- Spine and Intervertebral Disc Pathology
- Intraocular Surgery and Lenses
- Pharmaceutical Economics and Policy
- Cytomegalovirus and herpesvirus research
Ajou University
2024-2025
Chungnam National University Hospital
2022-2025
Ajou University Hospital
2023
Chungnam National University
2022-2023
Seoul National University Hospital
2016-2022
New Generation University College
2018-2022
Seoul National University
2022
Ulsan College
2010-2021
Asan Medical Center
2010-2021
University of Ulsan
2010-2021
A novel potassium-competitive acid blocker, DWP14012, is in clinical development as a potential alternative to proton pump inhibitors for the treatment of acid-related diseases.To evaluate safety, tolerability, pharmacodynamics and pharmacokinetics DWP14012 humans.A randomised, double-blind, double-dummy, placebo- active-controlled, single- multiple-ascending dose (SAD MAD, respectively) study was conducted healthy male subjects without Helicobacter pylori infection. Subjects randomly...
Summary Background Potassium‐competitive acid blockers (P‐CABs) are emerging as novel treatments for acid‐related disorders including gastroesophageal reflux disease. Tegoprazan and revaprazan approved P‐CABs in South Korea, but the pharmacodynamics safety/tolerability of two drugs have never been compared. Aims To evaluate tegoprazan after single multiple oral doses Methods A randomised, open‐label, active‐controlled study was conducted Helicobacter pylori ‐negative healthy Korean male...
This study analyzed clinical laboratory test results of healthy Korean volunteers screened for Phase 1 trials at Chungnam National University Hospital. Data from 53 conducted between 2019 and 2023 were extracted the Clinical Warehouse included tests such as white blood cell count, hemoglobin, aspartate aminotransferase, alanine creatinine. The aimed to evaluate whether current ranges "not clinically significant (NCS)" values need modification. Results showed that NCS often varied studies,...
Abstract This phase 1, randomized, open‐label, 2 × crossover study evaluated the bioequivalence of fixed‐dose combination (FDC) formulations alogliptin (ALO) and metformin extended‐release (MET XR) compared to their individual assessed effect food on FDC pharmacokinetics in healthy participants. The comprised high‐dose (ALO 25 mg/MET XR 1000 mg) low‐dose 12.5 500 mg), both conducted under fasting conditions, fed conditions. Among enrolled participants, 46 50 completed study, 45 51 22 26...
Tegoprazan, a novel potassium-competitive acid blocker, is used to treat acid-related diseases. However, there no information on the pharmacokinetic (PK) and pharmacodynamic (PD) profiles of marketed dosage tegoprazan under various meal timings in fed fasted state. The study aimed assess effect timing PKs PDs 50 mg after single administration healthy male subjects. An open-label, single-dose, three-treatment, three-period crossover was conducted. A total 12 subjects were orally administered...
Abstract Administration of sedatives for post-resuscitation care can complicate the determination optimal timing to avoid inappropriate, pessimistic prognostications. This prospective study aimed investigate distribution and elimination kinetics midazolam (MDZ) its metabolites, their association with awakening time. The concentrations MDZ seven metabolites were measured immediately at 4, 8, 12, 24 h after discontinuation infusion, using liquid chromatography-tandem mass spectrometry. area...
Background: LCB01-0371 is a novel oxazolidinone antibiotic that blocks protein production by binding to bacterial 23S ribosomes. This active against Gram-positive bacteria. study aimed evaluate the effect of food on pharmacokinetics (PKs) and its safety profile. Subjects methods: A randomized, open-label, two-way crossover was performed in 18 healthy Korean male subjects. All subjects received single oral 800 mg dose each period under fed or fasting condition with 7-day washout between. The...
Abstract Cenobamate (XCOPRI and ONTOZRY) is a novel antiseizure medication for the treatment of focal‐onset seizures. Nonetheless, there limited information on pharmacokinetics (PKs), safety, efficacy cenobamate in Asian people, including Japanese people. This study aimed to evaluate PKs safety after single oral dose healthy subjects compare with that reported non‐Japanese subjects. A randomized, double‐blind, placebo‐controlled, ascending was conducted at four levels 50, 100, 200, 400 mg....
Fixed-dose combinations (FDCs) of angiotensin II receptor blockers, calcium channel and statins are conventional therapeutic interventions prescribed for cardiovascular diseases. This study aimed at drawing a comparison between the pharmacokinetics safety an FDC corresponding individual formulations in healthy subjects.
The pharmacokinetic (PK) properties of drugs are affected in several ways by interactions with microbiota. aim this study was to investigate the effects oral vancomycin on gut microbiota and, consequently, PKs simvastatin. An open-label, single arm, sequential crossover conducted six healthy Korean male subjects. After 6 days a control diet, simvastatin 40 mg orally administered subjects before and after 1 week treatment. Blood samples for PK analysis fecal metagenomic metabolomic analyses...
The interaction between statins and omega-3 fatty acids remains controversial. aim of this phase 1 trial was to evaluate the pharmacokinetics drug-drug atorvastatin acids. Treatments were once-daily oral administrations (4 g), (40 mg), both for 14 days, 7 respectively, with washout periods. concentrations atorvastatin, 2-OH-atorvastatin, docosahexaenoic acid (DHA), eicosapentaenoic (EPA) determined LC-MS/MS. Parameters DHA EPA analyzed after baseline correction. A total 37 subjects completed...
Australia, 27.0% in the UK, 18.1% Germany, and 13.5% France.The obesity rate among Korean women was 5.5% 2019, which is much lower than that Western countries (OECD, 2021).Obesity a structural phenomenon occurs tandem with economic development lifestyle changes.Therefore, its incidence likely to increase future.LEPR gene encodes leptin receptor protein.It located on human chromosome 1p31.3(Vauthier et al., 2012).Leptin plays crucial role binding signaling of 1
Abstract DHP107 is a newly developed lipid‐based oral formulation of paclitaxel. We evaluated the in vivo tissue pharmacokinetics (PKs) mice and patients using positron emission tomography (PET). Radioisotope‐labeled [ 3 H]DHP107 18 F]DHP107 for administration were formulated same manner as manufacturing process DHP107. In PK assessed healthy ICR breast cancer xenografted SCID mice. Two with metastatic clinically absorption at target lesion after internal absorbed dose estimation. Whole‐body...
A 5.8 Gb/s/pin DRAM with unidirectional differential I/Os and 1 Gbit memory core was designed 23.2 GB/s module assembled. Tx BER measurement on an electrical test board similar to real sub-systempsilas environment performed the results show that no additional coding for I/O protection, like CRC, seems be required up operation. Also, efficient timing usage method using matched path a possible implementation of CRC computation in ODIC architecture proposed.
A 1-Gbit DRAM with 5.8-Gb/s/pin unidirectional differential I/Os was implemented by 70 nm process and a main memory module dual in-line assembled. The chips have control methods for core noise injection cyclic redundancy check (CRC) generator outer-data inner-command architecture. Measurements bit error rate jitter performance of the transmitter performed on an electrical test board which emulates real system's environment. Also, effect power analyzed from three class values decoupling...
The general linear model (GLM) describes the dependent variable as a combination of independent variables and an error term. GLM procedure SAS® "car" package in R calculate type I, II, or III ANOVA (analysis variance) tables. In this study, we validated newly-developed package, "sasLM," which is compatible with SAS®. "sasLM" was by comparing output SAS®, current gold standard for statistical programming. Data from ten books articles were used validation. results packages compared those using...
Chronic obstructive pulmonary disease (COPD) is a type of progressive, lung characterized by long-term poor airflow.The symptoms COPD may be relieved and its progression delayed fluticasone (FTS), salmeterol (SM), tiotropium (TTP).The aim this study to investigate pharmacokinetic (PK) characteristics inhaled FTS, SM, TTP after co-administration.An open-label, single-arm, three-period, simple ascending dose was conducted in 10 healthy male subjects.A single FTS/SM (250/50 μg) (18 were...
To investigate the possible effect of haemodialysis (HD) on pharmacokinetic (PK) and pharmacodynamic (PD) characteristics evogliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor.A single-dose, open-label, parallel-group study eight end-stage renal disease (ESRD) patients matched healthy subjects was conducted. ESRD received single oral dose evogliptin 5 mg after before HD with 2-week washout between each dose, mg. Serial blood, dialysate, urine samples were collected to assess PK PD profiles...
Despite the variety of treatment methods, comminuted inferior pole fractures patella remain difficult and technically demanding to achieve stable internal fixation. The purpose this study is evaluate clinical outcomes rim plate-augmented separate vertical wiring with supplementary fixation in management fractures, AO/OTA 34-A1, C2, C3, which has secondary horizontal fracture line on lower articular boundary. From our study, bony union was achieved all patients at an average 3.1 ± 1.4 months...
Abstract The combined cilostazol and rosuvastatin therapy is frequently used for coronary artery disease treatment. This open‐label, 3 × crossover clinical trial evaluated the pharmacokinetics safety of a fixed‐dose combination (FDC) cilostazol/rosuvastatin (200 + 20 mg) versus concurrent administration separate components (SCs) under both fasted fed conditions. Among 48 enrolled healthy adults, 38 completed study. Participants were administered single oral dose mg), either as an FDC or SCs...
Background: In clinical practice, primary healthcare physicians commonly encounter patients with alcohol-related problems. This review article introduces the concept of an alcohol clinic for treating these issues at clinics.Current Concepts: Alcohol-related problems often give rise to health problems, which prompts be required develop screening, treatment, and counseling skills. Primary clinics should actively screen Screening involves questions regarding frequency, quantity, maximum...