A5067794137- RNA Research and Splicing
- Drug Transport and Resistance Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Medical Imaging Techniques and Applications
- DNA and Nucleic Acid Chemistry
- Radiopharmaceutical Chemistry and Applications
- Biopolymer Synthesis and Applications
- Exercise and Physiological Responses
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Muscle Physiology and Disorders
- Integrated Circuits and Semiconductor Failure Analysis
- Acute Myeloid Leukemia Research
- Semiconductor materials and devices
- Liver Disease and Transplantation
- RNA Interference and Gene Delivery
- Advancements in Photolithography Techniques
- Ergonomics and Musculoskeletal Disorders
- RNA and protein synthesis mechanisms
- Cancer Research and Treatments
- bioluminescence and chemiluminescence research
- Animal Genetics and Reproduction
- Histone Deacetylase Inhibitors Research
- Advancements in Semiconductor Devices and Circuit Design
- Tryptophan and brain disorders
Ewha Womans University
2020-2024
Memorial Sloan Kettering Cancer Center
2012-2018
Iowa State University
2011
Seokyeong University
2005
Korea Research Institute of Bioscience and Biotechnology
1997-2000
Wonkwang University
1995
Hyperpolarized micro-NMR nondestructively analyzes metabolic activities in scant cells.
Sarcopenia- or cachexia-related muscle atrophy is due to imbalanced energy metabolism and oxidative stress-induced dysfunction. Monoterpenes play biological pharmacological reactive oxygen species (ROS) scavenging roles. Hence, we explored the effects of camphene, a bicyclic monoterpene, on skeletal in vitro vivo. We treated L6 myoblast cells with camphene then examined ROS-related stress using Mito TrackerTM Red FM anti-8-oxoguanine antibody staining. To investigate lipid metabolism,...
Introduction: Systemic chemotherapy is typically administered following radical gastrectomy for advanced stage. To attenuate systemic side effects, we evaluated the effectiveness of regional using paclitaxel, albumin-paclitaxel, and liposome-encapsulated albumin-paclitaxel via subserosal injection in rat models employing nuclear medicine molecular imaging technology. Method: Nine Sprague Dawley rats were divided into three groups: paclitaxel ( n = 3), nano-particles (APNs; APNs 3). [ 123...
Although aptamers have shown excellent target specificity in preclinical and clinical studies either by themselves or as aptamer-drug conjugates, their vivo tissue pharmacokinetic (PK) analysis is still problematic. We aimed to examine the utility of image-based positron emission tomography (PET) evaluate PK, specificity, applicability oligonucleotides. For this, fluorine-18-labeled with erb-b2 receptor tyrosine kinase 2 (ERBB2)-specific binding were synthesized base-pair hybridization using...
The skeletal muscles account for approximately 40% of the body weight and are crucial in movement, nutrient absorption, energy metabolism. Muscle loss decline function cause a decrease quality life patients elderly, leading to complications that require early diagnosis. Positron emission tomography/computed tomography (PET/CT) offers non-invasive, high-resolution visualization tissues. It has emerged as promising alternative invasive diagnostic methods is attracting attention tool assessing...
Acetaminophen overdose is a leading cause of acute liver failure (ALF), and effective treatment depends on early prediction disease progression. ALF diagnosis currently requires blood collection 24–72 h after APAP ingestion, necessitating repeated tests hospitalization. Here, we assessed earlier using positron emission tomography (PET) imaging translocator proteins (TSPOs), which are involved in molecular transport, oxidative stress, apoptosis, energy metabolism, with the radiotracer...
Imaging techniques for diagnosing muscle atrophy and sarcopenia remain insufficient, although various advanced diagnostic methods have been established. We explored the feasibility of 18F-fluorocholine (18F-FCH) positron emission tomography/computed tomography (PET/CT) evaluating skeletal atrophy, as an imaging technique that tracks choline level changes in muscles. Cell uptake L6 cells by 18F-FCH was performed a complete medium containing serum (untreated group, UN) serum-free (starved ST)....
Purpose The purpose of this paper is to develop a multi‐purpose body form that could be used different types garments by putting skins with ease on the standard form. Design/methodology/approach Free deformation method was generate virtual model upon basis averaged wire frame. made into real‐life rapid prototyping (RP) process, and then, molding RP. 3D polygon shell for skin got flattened down 2D patterns urethane material. Findings developed using scan data better represented...
A series of nano-sized dendritic alpha,epsilon-poly(L-lysine)s (DPL) were synthesized by the solid-phase peptide synthesis method, using a core epsilon-peptide structure consisting eight lysine residues. Surface amines alpha,epsilon-poly(L-lysine) characterized comparing retention times reverse phase HPLC with electrophoretic mobilities capillary zone electrophoresis (CZE) and non-denatured polyacrylamide gel (PAGE). The elution alpha,epsilon-poly(Llysine) in well correlated CZE PAGE....
Abstract DHP107 is a newly developed lipid‐based oral formulation of paclitaxel. We evaluated the in vivo tissue pharmacokinetics (PKs) mice and patients using positron emission tomography (PET). Radioisotope‐labeled [ 3 H]DHP107 18 F]DHP107 for administration were formulated same manner as manufacturing process DHP107. In PK assessed healthy ICR breast cancer xenografted SCID mice. Two with metastatic clinically absorption at target lesion after internal absorbed dose estimation. Whole‐body...
Macrophages are activated during the early phase of paracetamol-induced liver injury (PLI). [18F]GE180 is a radiolabeled ligand that recognizes macrophage translocator protein (TSPO). In this study, we evaluated feasibility TSPO-specific radiotracer in rat model PLI. A was induced by intraperitoneal administration paracetamol. positron emission tomography (PET) images were obtained after 24 h. The maximal and mean standardized uptake values (SUVmax SUVav) serum biomarker levels examined....
The SC-1 treatment prior to the O3/TEOS CVD was a very effective method for gapfilling nanoscale trench of high aspect ratio by improving adsorption TEOS precursors onto wall oxide. It found that interval duration after cleaning critical parameter contact angle and gapfill performance CVD.
The relevance of MDR‐1 gene expression to the multidrug resistance phenotype was investigated. Drug‐resistant cells, KB‐V1 and MCF7/ADR, constantly expressed mRNA were more resistant vinblastine adriamycin than drug‐sensitive KB‐3–1 MCF7. drug efflux rate same as although in only cell. higher intracellular concentration due large influx. In case MCF7 influx had nearly pattern not affected by verapamil. amount ATP, cofactor pumping activity P‐glycoprotein, changed resistance. These...
Saengmaeksan (SMS), a representative oriental medicine that contains Panax ginseng Meyer, Liriope muscari , and Schisandra chinensis (1:2:1), is used to improve body vitality enhance physical activity. However, there limited scientific evidence validate the benefits of SMS. Here, we investigated in vitro vivo regulatory effects SMS its constituents on energy metabolism underlying molecular mechanisms. For this, quantitative real-time polymerase chain reaction, 3D holotomographic microscopy,...
A series of nano-sized dendritic α,ε -poly(L-lysine)s (DPL) were synthesized by the solid-phase peptide synthesis method, using a core ε -peptide structure consisting eight lysine residues. Surface amines -poly(L-lysine) characterized comparing retention times reverse phase HPLC with electrophoretic mobilities capillary zone electrophoresis (CZE) and non-denatured polyacrylamide gel (PAGE). The elution in well correlated CZE PAGE. separation was dependent on size, shape molecule number...
Exercise can prevent conditions such as atrophy and degenerative brain diseases. However, owing to individual differences in athletic ability, exercise supplements be used improve a person's capacity. Schisandra chinensis (SC) is natural product with various physiologically active effects. In this study, we analyzed SC using pharmacological network determined whether it could an supplement.The compounds of target genes were identified the Traditional Chinese Medicine Database Analysis...