A5005301507- Drug Transport and Resistance Mechanisms
- Urinary Bladder and Prostate Research
- Pharmacogenetics and Drug Metabolism
- Diabetes Treatment and Management
- Antibiotics Pharmacokinetics and Efficacy
- Pelvic floor disorders treatments
- Pharmacological Effects and Toxicity Studies
- Retinal Diseases and Treatments
- Pharmaceutical studies and practices
- Kidney Stones and Urolithiasis Treatments
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Analytical Methods in Pharmaceuticals
- Retinal and Macular Surgery
- Urological Disorders and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Hormonal Regulation and Hypertension
- Drug-Induced Hepatotoxicity and Protection
- Pharmacological Effects of Natural Compounds
- Receptor Mechanisms and Signaling
- Urologic and reproductive health conditions
- Epilepsy research and treatment
- Glaucoma and retinal disorders
- Antimicrobial Resistance in Staphylococcus
- Pancreatic function and diabetes
Seoul National University Bundang Hospital
2016-2025
Seoul National University Hospital
2008-2025
Seoul National University of Science and Technology
2024-2025
Mount Sinai Hospital
2025
New York University
2025
Seoul National University
2005-2024
National University College
2008-2024
New Generation University College
2003-2024
Liechtenstein Institute
2023
Hudson Institute
2023
Abstract Purpose: The rationale for developing an alternative paclitaxel formulation concerns Cremophor EL-related side effects, and a novel delivery system might augment its therapeutic efficacy. Genexol-PM is polymeric micelle formulated free of EL. A phase I study was performed to determine the maximum tolerated dosage, dose-limiting toxicities, pharmacokinetic profile in patients with advanced, refractory malignancies. Experimental Design: Twenty-one were entered into study. i.v....
Pitavastatin is a potent, newly developed 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor for the treatment of hyperlipidemia. We characterized effects organic anion transporting polypeptide 1 B (OATP 1) alleles *1a, *1b, and *15 on pharmacokinetics pitavastatin.Twenty-four healthy Korean volunteers who had previously participated in pharmacokinetic study pitavastatin (single oral dose, 1--8 mg) were further investigated. Subjects grouped according to OATP genotype. Dose-normalized...
Purpose.: To analyze the intraocular pharmacokinetic properties of intravitreally injected ranibizumab in vitrectomized and nonvitrectomized rabbit eyes. Methods.: A procedure consisting 25-gauge pars plana vitrectomy without lensectomy posterior vitreous detachment was performed 18 eyes, eyes served as controls. Ranibizumab (0.25 mg/0.025 mL) all The were enucleated at 1 hour or 1, 2, 5, 14, 30 days after intravitreal injections frozen −80°C. concentrations vitreous, aqueous humor, retina...
We report on measurements of the Upsilon(1S), Upsilon(2S), and Upsilon(3S) differential cross sections (d(2)sigma/dp(T)dy)(/y/<0.4), as well Upsilon(1S) polarization in p macro collisions at square root s = 1.8 TeV using a sample 77+/-3 pb(-1) collected by collider detector Fermilab. The three resonances were reconstructed through decay Upsilon-->mu(+)mu(-). measured angular distribution muons rest frame is consistent with unpolarized meson production.
Abstract Metformin is a first-line drug for treating type 2 diabetes. Although metformin known to phosphorylate AMP-activated protein kinase (AMPK), it unclear how the glucose-lowering effect of related AMPK activation. The aim this study was identify urinary endogenous metabolites affected by and novel underlying molecular mechanisms its anti-diabetic effect. Fourteen healthy male subjects were orally administered (1000 mg) once. First morning urine samples taken before after administration...
Purpose: We determined the intraocular pharmacokinetic properties of intravitreally injected aflibercept (Eylea) in a rabbit model. Methods: Aflibercept was 21 eyes from New Zealand White rabbits. The were enucleated 1, 24, 48, 120, 216, 360, and 720 hours (1, 2, 5, 9, 15, 30 days, respectively) after injection immediately frozen at −80°C. concentrations vitreous, aqueous humor, retina/choroid by performing an indirect enzyme-linked immunosorbent assay, analyzed to understand drug. Results:...
We evaluated the effect of pregnane X receptor (PXR) agonist rifampin on metformin pharmacokinetics, organic cation transporter 1 (OCT1) and OCT2 mRNA levels, glucose using oral tolerance test (OGTT) in 16 healthy subjects. The glucose-lowering effects were by OGTT before after treatment days 2 again 13 14 a 10-day course rifampin. Rifampin increased difference maximum levels (ΔGmax) 41.9% (P = 0.024) area under concentration–time curve (AUC) during first 60 min ingestion (ΔAUCgluc60) 54.5%...
Ursodeoxycholic acid (UDCA) is a metabolic by-product of intestinal bacteria, showing hepatoprotective effects. However, its underlying molecular mechanisms remain unclear. The purpose this study was to elucidate the action protective effects UDCA and vitamin E against liver dysfunction using metabolomics metagenomic analysis. In study, we analysed blood urine samples from patients with obesity dysfunction. Nine were randomly assigned receive (300 mg twice daily), 10 subjects received (400...
The organic cation transporter 1 (OCT1) plays a key role in the cellular transport of metformin and its subsequent glucose-lowering effect. A recent non-clinical study reported that uptake into hepatocytes is regulated via OCT1, was strongly inhibited by verapamil. Therefore, we investigated effects verapamil co-administration on pharmacokinetics pharmacodynamics humans.We evaluated anti-hyperglycaemic using an oral glucose tolerance test (OGTT) 12 healthy participants, before (day 1) after...
Background and Objectives There have been considerable disagreements regarding the influence of MDR1 (ABCB1) polymorphisms on disposition P-glycoprotein (P-gp) substrates. We speculated that unknown function A allele exon 21 G2677T/A (Ala893Ser/Thr) provides one reasons for contradictory results. This study was performed to clarify effects major gene polymorphisms, including a variant in 21, fexofenadine pharmacokinetics. Methods investigated occurrence 3 high-frequency single-nucleotide...
Our objective was to investigate the effect of uridine 5'-diphosphate-glucuronosyltransferase (UGT) 2B15 genetic polymorphism on pharmacokinetics and pharmacodynamics lorazepam in basal, inhibited, induced metabolic states healthy normal volunteers.Twenty-four subjects were enrolled grouped into UGT2B15*1/*1 or UGT2B15*2/*2 genotype groups. The pharmacokinetic pharmacodynamic profiles intravenous characterized before after inhibition with 600 mg valproate once daily for 4 days induction...
Pharmacokinetic and pharmacodynamic profiles of lorazepam valproate were analyzed according to uridine 5′-diphosphate-glucuronosyltransferase (UGT)2B7 genotype in 14 healthy subjects with UGT2B15*2/*2 genotype. Systemic clearance (2 mg intravenously) area under the concentration–time curve (AUC) (600 once daily for 4 days) as pharmacokinetic parameters, effect–time (AUEC) psychomotor coordination tests (Vienna) was used parameter. No significant differences found systemic clearances by...
Abstract To investigate pharmacokinetic and pharmacodynamic differences of zolpidem between males females their causes, including CYP3A4 activity. A single oral dose (10 mg) was administered to 15 male female healthy subjects. Blood samples were collected up 12 h post-dose determine plasma concentrations. Pharmacokinetic parameters obtained using non-compartmental analysis. Digit symbol substitution test, choice reaction time, visual analog scale sleepiness used evaluate pharmacodynamics. We...
Although metformin has been reported to affect the gut microbiome, mechanism not fully determined. We explained potential underlying mechanisms of through a multiomics approach.An open-label and single-arm clinical trial involving 20 healthy Korean was conducted. Serum glucose insulin concentrations were measured, stool samples collected analyze microbiome. Untargeted metabolomic profiling plasma, urine, performed by GC-TOF-MS. Network analysis applied infer hypoglycemic effect metformin.The...
The phosphodiesterase (PDE) type 5 inhibitor is a widely used agent that facilitates penile erection. Udenafil newly developed as PDE-5 inhibitor.This the first study to determine safety, tolerability and pharmacokinetics of udenafil in healthy subjects. was safe well tolerated Korean AUC C(max) increased supraproportionally with increasing dose upon single administration, but there no significant drug accumulation multiple administrations.To evaluate (PK) udenafil, novel inhibitor.A...
The intraocular route of drug administration enables the delivery high concentrations therapeutic drugs, while minimizing their systemic absorption. Several drugs are administered into anterior chamber or vitreous, and injection has been effective in curing various diseases. Rabbit eyes have widely used for ophthalmic research, as animal is easy to handle economical compared other mammals, size a rabbit eye similar that human eye. Using 30 G needle, can be injected intracameral intravitreal...
As inhibitors of organic cation transporters (OCTs), proton pump (PPIs) may affect the plasma levels metformin, an OCT substrate. We investigated effects two PPIs, pantoprazole and rabeprazole, on metformin pharmacokinetics glucose in healthy subjects. In this open, randomized, six-sequence, three-period crossover study, 24 participants were administered either alone or combination with rabeprazole. The concentrations serum after a 75-g oral tolerance test (OGTT) determined. area under...
Objectives Human urate transporter 1 (URAT1) is a member of the organic anion family (SLC22A12) that primarily regulates renal tubular reabsorption uric acid. This case–control study was designed to analyse whether hURAT1 might also be candidate gene for hyperuricaemia or hypouricaemia. Setting We recruited 68 healthy volunteers and divided them into two groups: normal acid group group. analysed sequence URAT1 found five significant single nucleotide polymorphisms (SNPs). then selected 900...