A5101908526- Gut microbiota and health
- Analytical Methods in Pharmaceuticals
- Statistical Methods in Clinical Trials
- Clostridium difficile and Clostridium perfringens research
- Biosimilars and Bioanalytical Methods
- Diet and metabolism studies
- Diabetes Treatment and Management
- Cytokine Signaling Pathways and Interactions
- Metabolomics and Mass Spectrometry Studies
- HIV Research and Treatment
- Gastroesophageal reflux and treatments
- Acupuncture Treatment Research Studies
- Traditional Chinese Medicine Studies
- Ginseng Biological Effects and Applications
- Potassium and Related Disorders
- Pharmaceutical Economics and Policy
- Pharmacology and Obesity Treatment
- S100 Proteins and Annexins
- Helicobacter pylori-related gastroenterology studies
- Psoriasis: Treatment and Pathogenesis
- Facial Nerve Paralysis Treatment and Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Catalytic Processes in Materials Science
- Functional Brain Connectivity Studies
- Metabolism, Diabetes, and Cancer
Seoul National University Hospital
2018-2024
Seoul National University
2021-2022
Korea Advanced Institute of Science and Technology
2011-2019
Although metformin has been reported to affect the gut microbiome, mechanism not fully determined. We explained potential underlying mechanisms of through a multiomics approach.An open-label and single-arm clinical trial involving 20 healthy Korean was conducted. Serum glucose insulin concentrations were measured, stool samples collected analyze microbiome. Untargeted metabolomic profiling plasma, urine, performed by GC-TOF-MS. Network analysis applied infer hypoglycemic effect metformin.The...
ABSTRACT The corrected QT (QTc) interval is a critical marker for assessing proarrhythmic potential in drug development, while the JT (JTc) provides specific insight into ventricular repolarization. This study quantitatively analyzed relationships of QTc and JTc intervals with age sex utilizing large real‐world dataset hospital‐based controls moxifloxacin‐treated patients. retrospective 1,039,550 electrocardiograms associated clinical data extracted from previously constructed...
Abstract Metformin is a major treatment for type 2 diabetes. This study was conducted to investigate the impact of gut microbiome dysbiosis on pharmacokinetics and antihyperglycemic effects metformin. Healthy adult males aged 19–45 years with no defecation abnormalities were recruited this 4‐period clinical study: baseline; post‐metformin (i.e., multiple oral doses 1000 mg metformin days 1–4); post‐vancomycin 500 vancomycin 11–17 inducing changes); + 16–19). In each period, serum glucose...
Several classes of antibiotics have reduced the mortality caused by infectious diseases; however, orally administered alter composition gut microbiota, leading to dysbiosis-related disease. Therefore, in this study, we used 16S rRNA gene sequencing- and metabolomics-based approaches investigate effects oral vancomycin on bacterial microbiota metabolome biospecimens collected from healthy men. Samples 11 men were analyzed using sequencing metabolomics. was performed analyze GC-TOFMS-based...
Abstract Fexuprazan, a novel potassium‐competitive acid blocker, is expected to be used for the prevention of nonsteroidal anti‐inflammatory drugs (NSAIDs) induced ulcer. This study aimed evaluate pharmacokinetic (PK) interactions between fexuprazan and NSAIDs in healthy subjects. A randomized, open‐label, multicenter, six‐sequence, one‐way crossover was conducted male Subjects randomly received one (fexuprazan 40 mg BID, celecoxib 200 naproxen 500 or meloxicam 15 QD) 5 7 days first period...
In this study, the synthesis of a novel catalyst WO3/MoCl5 was carried out by thermal method. The method gave an entirely different product compared to previous studies that doped Mo on surface semiconductor metal oxides. degradation reaction crystal violet (CV) and rhodamine B (RB) dye were done without any energy source. results showed incomparably superior result for degradation, with rate constant 1.74 s−1 30 ppm CV, 1.08 RB, higher value than 1 both cases 50 solution. To author’s...
Demonstration of bioequivalence (BE) is mandatory while developing generic drugs. The scientific concept BE applies equally to different regulatory agencies. However, the application may differ for each agency, which can affect design studies. To evaluate study practices in terms South Korea, we retrospectively analyzed reports available from Ministry Food and Drug Safety between 2013 2019. Statistical estimation pharmacokinetic parameters, including peak concentration area under...
Abstract Eslicarbazepine acetate (ESL) is a prodrug antiseizure medication for the treatment of focal seizures. ESL shows well‐established pharmacokinetic (PK)‐pharmacodynamic relationship and has similar extrinsic epilepsy‐related factors across ethnicities. This study evaluated compared safety, tolerability, PK characteristics between Korean White subjects. A randomized, double‐blind, placebo‐controlled, single‐ multiple‐dose escalation was conducted in healthy adults. Participants...
Purpose: Fixed-dose combination (FDC) of gemigliptin and rosuvastatin may improve medication compliance patients with comorbid type 2 diabetes dyslipidemia. Pharmacokinetics (PK), pharmacodynamics (PD), safety gemigliptin/rosuvastatin 50/20 mg FDC was compared a loose individual tablets in healthy subjects. Patients methods: A randomized, open-label, single-dose, two-period, two-sequence, two-treatment crossover study conducted. Subjects received or (50 mg) (20 during each period, 14-day...
A fixed-dose combination (FDC) of gemigliptin/metformin can improve the medication adherence in patients with type 2 diabetes mellitus (T2DM). In this study, pharmacokinetic (PK) and pharmacodynamic (PD) profiles gemigliptin metformin were compared between FDC corresponding loose under fasted fed states. two-part, randomized, open label, single-dose, two-way crossover study was conducted healthy male subjects. Under (part 1) or 2) state, tablets sustained release (SR) 25/500 mg one tablet 50...
Abstract Fixed‐dose combination (FDC) drugs with various dose combinations for the treatment of type 2 diabetes mellitus and dyslipidemia are currently in demand. We compared pharmacokinetic (PK) profiles rosuvastatin/metformin sustained‐release (10/1000 mg) FDC separate tablets evaluated effect food by randomized, open‐label, 3‐period, 6‐sequence crossover studies conducted healthy male subjects. Subjects were randomly assigned to one following treatments: 10 mg rosuvastatin 1000 metformin...
Varenicline is an efficacious aid for smoking cessation. In this study, the pharmacokinetics and safety were compared between film-coated tablets of varenicline tartrate (reference drug) newly developed orally disintegrating films salicylate (test drug), both them contained 1 mg varenicline.A randomized, open-label, single-dose, two-sequence, two-period crossover study was conducted in healthy male subjects. Serial blood samples obtained up to 72 hours each period, with a washout period 7...
Tenofovir is the representative treatment for human immunodeficiency virus and hepatitis B infection. This study was conducted to assess pharmacokinetics (PKs) safety characteristics after a single administration of tenofovir disoproxil phosphate compared fumarate in healthy male subjects. An open-label, randomized, administration, two-treatment, two-sequence crossover 37 volunteers. Serial blood samples were collected up 72 hours. Non-compartmental analysis used calculate PK parameters. The...
Abstract The stimulation paradigms of a functional MRI (fMRI) usually consist one or more stimulations and resting state in the block‐based event‐related designs. To localize activation areas human brain, each voxel is statistically analyzed using fMRI data measured with stimulation. conventional method can be inefficient for experiments multiple stimuli because measuring resting‐state signals repeatedly, causing redundancy scanning process. Although phase mapping applied to reduce redundant...
Background
Background
Objectives This report aimed to investigate the possibility of correcting facial asymmetry using cervical Chuna manipulation treatment and functional cerebrospinal technique introduce meaningful additional improvement systemic symptoms non-surgical Korean medicine treatments through three case studies. Methods Three patients with were treated treatments. The effects all measured photographs, lateral cephalograms, whole-body radiogram Likert scale. Results After treatment, there significant...