A5002018432- Cardiac Arrhythmias and Treatments
- Virus-based gene therapy research
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Effects of Exercise
- Atrial Fibrillation Management and Outcomes
- CRISPR and Genetic Engineering
- Viral Infections and Immunology Research
- Tissue Engineering and Regenerative Medicine
- Cardiac pacing and defibrillation studies
- Cardiac Fibrosis and Remodeling
- Viral Infectious Diseases and Gene Expression in Insects
- Cardiovascular Function and Risk Factors
- Electrostatic Discharge in Electronics
- Cardiovascular Disease and Adiposity
- Congenital heart defects research
- RNA and protein synthesis mechanisms
- Electrospun Nanofibers in Biomedical Applications
- Pluripotent Stem Cells Research
- Cardiac Imaging and Diagnostics
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Prostate Cancer Treatment and Research
- Cardiac Ischemia and Reperfusion
- Telomeres, Telomerase, and Senescence
- Viral gastroenteritis research and epidemiology
Garvan Institute of Medical Research
2023
The Kinghorn Cancer Centre
2023
The University of Sydney
2014-2022
Westmead Institute for Medical Research
2017-2022
Westmead Hospital
2015-2019
Westmead Institute
2016
Abstract We have previously reported a subpopulation of mesenchymal stromal cells (MSCs) within the platelet-derived growth factor receptor-alpha (PDGFRα)/CD90 co-expressing cardiac interstitial and adventitial cell fraction. Here we further characterise PDGFRα/CD90-expressing MSCs (PDGFRα + cMSCs) use human telomerase reverse transcriptase (hTERT) over-expression to increase cMSCs ability repair heart after induced myocardial infarction. hTERT in PDGFRα (hTERT modulates differentiation,...
Recent studies have demonstrated that intramyocardial adipose tissue (IMAT) may contribute to ventricular electrophysiological remodeling in patients with chronic myocardial infarction. Using an ovine model of infarction, we aimed determine the influence IMAT on scar identification during endocardial contact mapping and optimal voltage-based criteria for defining dense regions.In 7 sheep, left transmural was performed 84 weeks (15-111 weeks) post-myocardial Spearman rank correlation...
To define the temporal characteristics of atrial lesion growth (lesion surface area), local electrogram amplitude attenuation, and circuit impedance decrement during in vivo radiofrequency (RF) ablation with direct endocardial visualization (DEV).A catheter was used for real-time endoscopic RF ablation. Videos (surface impedance, were recorded 11 ovine. Fifty-two ablations at 12 W, 14 16 W power 30 seconds analyzed. During 30-second ablation, matured (90% final dimension) first 23.0 ± 5.8...
Introduction Sheep have been adopted as a pre-clinical large animal for scientific research they are good models of cardiac anatomy and physiology, allow investigation pathophysiological processes which occur in the mammalian heart. There is, however, no defined model atrioventricular block sheep to assessment new treatment options. We therefore aimed develop an adult with focus on future novel applications. Methods results utilized six undergo two procedures each. The first procedure...
Sinoatrial node dysfunction can manifest as bradycardia, leading to symptoms of syncope and sudden cardiac death. Electronic pacemakers are the current standard care but limited due a lack biological chronotropic control, cost revision surgeries, risk lead- device-related complications. We therefore aimed develop alternative electronic devices by using clinically relevant gene therapy vector demonstrate conversion cardiomyocytes into sinoatrial node-like cells in an vitro context. Neonatal...
Increased myocardial structural heterogeneity in response to ischemic injury following infarction (MI) is purported as the mechanism of ventricular arrhythmogenesis. Current modalities for vivo assessment identification arrhythmogenic substrate are limited due complex nature microenvironment post-MI. We investigated utility bio-impedance spectroscopy (BIS) a large post-infarct animal model differentiation between normal and infarcted tissue. also quantitative effects adipose collagen on BIS...
Objective: To compare medium-term outcomes of active surveillance (AS) for men with favourable risk International Society Urologic Pathology (ISUP)-2 prostate cancer (PCa) to a pair matched group ISUP-1 PCa. Methods: This was retrospective analysis prospectively collected data from single institution clinical registry, using propensity score matching. Men enrolled on AS ISUP-2 PCa minimum 5-year follow-up were 1:2 disease. We assessed rates progression treatment, metastatic disease, adverse...
Gene therapy is making significant impact on a modest, yet growing, number of human diseases. Justifiably, the preferred viral vector for clinical use that based recombinant adeno-associated virus (rAAV). There need to scale up rAAV production with transition from pre-clinical models application. Standard methods adherent cell type (HEK293) are limited in scalability and other methods, such as those baculovirus non-adherent insect (Sf9) system, have been pursued an alternative increase...