A5036346543- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Noise Effects and Management
- Ear Surgery and Otitis Media
- Vestibular and auditory disorders
- Biochemical Analysis and Sensing Techniques
- Neuroscience of respiration and sleep
- Neuroscience and Neuropharmacology Research
- Connexins and lens biology
- Animal Vocal Communication and Behavior
- Nitric Oxide and Endothelin Effects
- Bat Biology and Ecology Studies
- Orthopaedic implants and arthroplasty
- Gene Regulatory Network Analysis
- Obstructive Sleep Apnea Research
- Tracheal and airway disorders
- Optical Imaging and Spectroscopy Techniques
- Neural dynamics and brain function
- Infant Health and Development
- Neurological Disease Mechanisms and Treatments
- Ion Channels and Receptors
- Phonocardiography and Auscultation Techniques
- Nerve injury and regeneration
- RNA regulation and disease
- Total Knee Arthroplasty Outcomes
Shanghai Jiao Tong University
2016-2025
Shanghai Ninth People's Hospital
2017-2025
Liechtenstein Institute
2023
Beihang University
2022
Shenyang Ninth People's Hospital
2020
Soochow University
2020
Wuxi Ninth People's Hospital
2020
XinHua Hospital
2011-2016
Renmin Hospital of Wuhan University
2005-2009
Wuhan University
2005-2009
To investigate the effects of personal listening device use on hearing in young listeners.Conventional frequency audiometry (0.5-8 kHz) and extended high-frequency (10-20 were performed 120 users 30 normal-hearing adults.The thresholds 3 to 8 kHz range significantly increased listeners. The became broad as exposure duration was increased. Impaired detected 14.1% (34 240 ears) ears (> 25 dB HL one or more frequencies 0.5-8 kHz). could also be even if their conventional normal.Our results...
Abstract Background Significant sex differences exist in hearing physiology, while few human studies have investigated noise-induced loss (NIHL), and the bias previous resulted inadequate female data. The study aims to investigate characteristics of NIHL provide insight into sex-specific risk factors, prevention strategies treatment for NIHL. Methods This cross-sectional included 2280 industrial noise-exposed shipyard workers (1140 males 1140 females matched age, job employment length)...
Salicylate, one of the most widely used drugs, produces at repetitive high doses reversible tinnitus and hearing loss. Neural correlates loss have long been established, whereas they remain elusive for tinnitus. The average spectrum electrophysiological cochleoneural activity (ASECA), a measure spontaneous auditory nerve activity, was monitored in guinea pigs over weeks salicylate administration. Auditory compound action potential (CAP) also recorded to monitor acoustic sensitivity. In first...
Postnatal permanent childhood hearing impairment (PCHI) is frequent (0.25%–0.99%) and difficult to detect in the early stage, which may impede speech, language cognitive development of affected children. Genetic tests common variants associated with postnatal PCHI newborns provide an efficient way identify those at risk. In this study, we detected a strong association p.V37I exclusive genotype GJB2 Chinese Hans (P = 1.4×10−10; OR 62.92, 95% CI 21.27–186.12). This Eastern Asians was present...
Tinnitus could be associated with neuronal hyperactivity in the auditory center. As a activity marker, immediate-early gene (IEG) expression is considered part of general response to natural stimuli. Some IEGs, especially activity-dependent cytoskeletal protein (Arc) and early growth gene-1 (Egr-1), appear highly correlated sensory-evoked activity. We hypothesize, therefore, an increase Arc Egr-1 will observed tinnitus model. In our study, we used gap prepulse inhibition acoustic startle...
The objective of the study was to identify acute high-intensity recreational noise-induced effects on auditory function, especially cochlear synaptopathy-related audiological metrics, in humans with normal hearing.This prospective cohort enrolled 32 young adults (14 males and 18 females); mean age 24.1 ± 2.4 years (ranging from 20 29). All participants hearing (audiometric thresholds ≤25 dB HL at frequencies 0.25, 0.5, 1, 2, 3, 4, 6, 8 kHz for both ears) had already decided participate...
This study aimed to quantitatively assess the incidence of hearing loss in relation age individuals with biallelic p.V37I variant GJB2.Population screening was performed 30,122 aged between 0 and 97 years Shanghai. Hearing thresholds controls were determined by click auditory brainstem response or pure tone audiometry.Biallelic detected 0.528% (159/30,122) subjects. Of newborns, 43.91% (18/41) passed their distortion-product otoacoustic emissions-based newborn had lower than 20 decible above...
Salicylate, a common drug frequently used long term in the clinic, is well known for causing reversible hearing loss and tinnitus. Our previous study, however, demonstrated that chronic administration of salicylate progressively raised amplitude distortion product otoacoustic emissions (DPOAEs), which are mainly caused by (outer hair cell) OHC electromotility. How affects electromotility to cause this paradoxical increase remains unclear. One possibility it could affect prestin, motor...
Abstract Recessive mutations in SLC26A4 and rarer cases double heterozygous of FOXI1/SLC26A4 KCNJ10/SLC26A4 lead to hearing impairment associated with enlarged vestibular aqueduct (EVA), the most common inner ear malformation. In our large cohort study, we addressed several important questions molecular etiology this disorder. The overall prevalence nonsyndromic childhood sensorineural loss (11.2%, 37/330) were determined by sequencing 330 impaired children who did not undergo radiologic...
Universal newborn hearing screening (UNHS) is recognized as the most effective strategy for early detection of congenital loss; however, coverage remains inadequate in many countries. In China, has been implemented over two decades. To evaluate our policies and practices during this period assess resource equity, health impacts, future challenges, we conducted a nationwide survey focusing on coverage, number special schools deaf-mutes, proportion hearing-impaired students mainstream...
Several single nucleotide polymorphisms (SNPs) of the Glutamate metabotrophic receptor 7 gene (GRM7) have recently been identified by genome-wide association study (GWAS) as potentially playing a role in susceptibility to age-related hearing impairment (ARHI), however this has not validated Han Chinese population. The aim was determine if these SNPs are also associated with ARHI an elderly male In case-control candidate genes study, total 982 men and 324 normal-hearing controls subjects were...
Objectives Universal neonatal hearing screening (UNHS) started late in some underdeveloped areas China, with relatively scarce resources and a wide regional distribution. This study aimed to compare the performance between rural urban populations, examine characteristics problems of UNHS regions China. Methods A two-step program was used neonates born Liuzhou Maternal Child Health Hospital patients who were other hospitals, but admitted intensive care unit. involved distortion product...
Abstract Tinnitus is associated with neural hyperactivity in the central nervous system (CNS). Salicylate a well-known ototoxic drug, and we induced tinnitus rats using model of long-term salicylate administration. The gap pre-pulse inhibition acoustic startle test was used to infer perception, only chronic salicylate-treatment (14 days) group showed evidence experiencing tinnitus. After small animal positron emission tomography scans were performed, found that metabolic activity inferior...
Abstract The homozygous p.V37I variant in GJB2 is prevalent East and Southeast Asians may lead to mild-to-moderate hearing loss with reduced penetrance. To investigate the pathogenic mechanism underlying this variant, we generated a knock-in mouse model of by an embryonic stem cell gene targeting method. Auditory brainstem response test showed that mice developed progressive, over first 4–9 months. Overall no significant developmental morphological abnormality was observed cochlea, while...
Auditory brainstem response (ABR) serves as an objective indication of auditory perception at a given sound level and is nowadays widely used in hearing function assessment. Despite efforts for automation over decades, ABR threshold determination by machine algorithms remains unreliable thereby one still relies on visual identification trained personnel. Here, we described procedure automatic that can be both animal human tests. The method terminates averaging recordings upon detection...
Yang T, Li X, Huang Q, L, Chai Y, Sun Wang Zhu Z, Wu H. Double heterozygous mutations of MITF and PAX3 result in Waardenburg syndrome with increased penetrance pigmentary defects. (WS) is characterized by sensorineural hearing loss defects the hair, skin, iris. Heterozygous its transactivator gene are associated type II (WS2) I (WS1), respectively. Most patients or mutations, however, show variable WS‐associated phenotypes even within families segregating same mutation, possibly mediated...
Objective: The aim of this study was to investigate the satisfaction age-related hearing loss (ARHL) or presbycusis patients with individual, accurate, and precise fitting progress, which is a priority for bilateral aids, explore related influencing factors their role in predicting efficiency aids. Methods: A total 73 cases aged 60–95 years old underwent pure tone audiometry speech recognition ability examination obtain better ear (BPTA) maximum rate (BSRR) quiet environment before aid...