A5100602024- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Noise Effects and Management
- Bacterial Identification and Susceptibility Testing
- Neuroscience of respiration and sleep
- Nasal Surgery and Airway Studies
- Hearing Impairment and Communication
- Respiratory and Cough-Related Research
- Antibiotic Use and Resistance
- Nerve injury and regeneration
- Ear Surgery and Otitis Media
- Neuroscience and Neuropharmacology Research
- Connexins and lens biology
- Pneumonia and Respiratory Infections
Shanghai Ninth People's Hospital
2018-2025
Shanghai Jiao Tong University
2018-2025
East China Normal University
2025
Abstract Background Significant sex differences exist in hearing physiology, while few human studies have investigated noise-induced loss (NIHL), and the bias previous resulted inadequate female data. The study aims to investigate characteristics of NIHL provide insight into sex-specific risk factors, prevention strategies treatment for NIHL. Methods This cross-sectional included 2280 industrial noise-exposed shipyard workers (1140 males 1140 females matched age, job employment length)...
In hospitalized patients, inadequate antibiotic dosage leading to bacterial resistance and increased antimicrobial use intensity due overexposure antibiotics are common problems. the present study, we constructed a machine learning model based on patients' clinical information predict effectiveness of Piperacillin-tazobactam (TZP) (4:1) in treating lower respiratory tract infections (LRTIs), assist clinicians making better decisions. We collected data from patients diagnosed with LRTIs or...
Universal newborn hearing screening (UNHS) is recognized as the most effective strategy for early detection of congenital loss; however, coverage remains inadequate in many countries. In China, has been implemented over two decades. To evaluate our policies and practices during this period assess resource equity, health impacts, future challenges, we conducted a nationwide survey focusing on coverage, number special schools deaf-mutes, proportion hearing-impaired students mainstream...
Auditory brainstem response (ABR) serves as an objective indication of auditory perception at a given sound level and is nowadays widely used in hearing function assessment. Despite efforts for automation over decades, ABR threshold determination by machine algorithms remains unreliable thereby one still relies on visual identification trained personnel. Here, we described procedure automatic that can be both animal human tests. The method terminates averaging recordings upon detection...
Abstract Background Hearing loss and lifestyle factors have been associated with cognitive impairment. We aimed to explore the joint association of combined healthy hearing impairment, which has scarcely studied. Methods This baseline study used data from CHOICE-Cohort (Chinese Solution for Improvement Cognition in Elders). was assessed by better-ear pure-tone average (BPTA). A composite score built based on never smoking, drinking, regular physical activity, balanced diet. Cognitive...
Age-related hearing loss (ARHL) signifies the bilateral, symmetrical, sensorineural that commonly occurs in elderly individuals. Several studies have suggested a higher risk of dementia among patients diagnosed with ARHL. Although precise causal association between ARHL and cognitive decline remains unclear, has been recognized as one most significant factors can be modified to reduce developing potentially. Mild impairment (MCI) typically serves initial stage transition from normal function...
Background: The definition of notched audiogram for noise-induced hearing loss (NIHL) is presently based on clinical experience, but audiometric phenotypes NIHL are highly heterogeneous. data-driven clustering subtypes could provide refined characteristics NIHL, and help identify individuals with typical at diagnosis. Methods: This cross-sectional study initially recruited 12,218 occupational noise-exposed employees aged 18–60 years from two factories a shipyard in Eastern China. Of these,...
Hypothesis: We investigated whether salicylate induces tinnitus through alteration of the expression levels brain-derived neurotrophic factor (BDNF), proBDNF, tyrosine kinase receptor B (TrkB), cAMP-responsive element-binding protein (CREB), and phosphorylated CREB (p-CREB) in auditory cortex (AC). Background: Salicylate medication is frequently used for long-term treatment clinical settings, but it may cause reversible tinnitus. Salicylate-induced associated with changes related to central...
It is widely accepted that even a single acute noise exposure at moderate intensity induces temporary threshold shift (TTS) can result in permanent loss of ribbon synapses between inner hair cells and afferents. However, effects repeated or chronic exposures on the cochlear especially medial olivocochlear (MOC) efferent remain elusive. Based weeklong model bandwidth over 2-20 kHz for 2 hours seven intensities (88 to 106 dB SPL with 3 increment per gradient) C57BL/6J mice, we attempted...
With a high prevalence of noise-induced hearing loss (NIHL), the noise survey tools for identifying individuals with risk NIHL are still limited. This study was aimed to translate and develop Chinese version exposure questionnaire (C-NEQ), validate its reliability reproducibility.This conducted from May 2020 March 2021 in China. The translated original NEQ adapted into culture using method according International Test Committee. Content validity evaluated by our expert group. Construct C-NEQ...
Objective: To study the characteristics of wideband tympanometry(WBT) and its application value in diagnosis otitis media with effusion(OME) young children. Methods: We compared acoustic energy absorbance(EA) under peak pressure children OME(190 ears) healthy control subjects(121 from Ninth People's Hospital Shanghai Jiaotong University School Medicine between January 2018 June 2020. Both groups were divided into three groups, 1-6 months, 7-36 months 37-72 months. SPSS 20.0 statistical...
Summary Auditory brainstem response (ABR) serves as an objective indication of auditory perception at given sound level and is nowadays widely used in hearing function assessment. Despite efforts for automation over decades, threshold determination by machine algorithm remains unreliable thereby still rely on visual identification trained personnel. Here, we described a procedure automatic that can be both animal human ABR tests. The method terminates averaging recordings upon detection...