Conor J. Loy
A5044029540- Spaceflight effects on biology
- Cancer Genomics and Diagnostics
- Extracellular vesicles in disease
- Hematopoietic Stem Cell Transplantation
- Cancer-related molecular mechanisms research
- Mycobacterium research and diagnosis
- RNA modifications and cancer
- MicroRNA in disease regulation
- High Altitude and Hypoxia
- Kawasaki Disease and Coronary Complications
- Inflammasome and immune disorders
- Aerospace Engineering and Energy Systems
- Diagnosis and treatment of tuberculosis
- SARS-CoV-2 and COVID-19 Research
- Systemic Lupus Erythematosus Research
- Lymphatic System and Diseases
- Renal and related cancers
- Circadian rhythm and melatonin
- Prenatal Screening and Diagnostics
- Viral Infections and Immunology Research
- Health, Environment, Cognitive Aging
- Single-cell and spatial transcriptomics
- Cancer Cells and Metastasis
- Genetics, Aging, and Longevity in Model Organisms
- 3D Printing in Biomedical Research
Denison University
2024
Cornell University
2020-2024
Weill Cornell Medicine
2024
Ithaca College
2023
Spaceflight induces molecular, cellular and physiological shifts in astronauts poses myriad biomedical challenges to the human body, which are becoming increasingly relevant as more humans venture into space
Spaceflight induces an immune response in astronauts. To better characterize this effect, we generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data for the SpaceX Inspiration4 (I4) mission crew. We found that 18 cytokines/chemokines related to inflammation, aging, muscle homeostasis changed after spaceflight. In I4 single-cell multi-omics data, identified a "spaceflight signature" of gene expression characterized by enrichment oxidative phosphorylation, UV...
Abstract Background The Inspiration4 (I4) mission, the first all-civilian orbital flight investigated physiological effects of short-duration spaceflight through a multi-omic approach. Despite advances, there remains much to learn about human adaptation spaceflight's unique challenges, including microgravity, immune system perturbations, and radiation exposure. Methods To provide detailed genetics analysis we collected dried blood spots pre-, during, post-flight for DNA extraction. Telomere...
Significance Hematopoietic cell transplantation is the gold standard treatment for many blood disorders, including cancers. Nonetheless, frequent post-transplant complications limit long-term benefit of HCT. Here, we find that circulating cell-free DNA a highly versatile analyte monitoring most important HCT: Graft-Versus-Host Disease, infection, graft failure and disease relapse. We show these different therapeutic can be informed from single sequencing assay followed by disease-specific...
Abstract Tuberculosis (TB) remains a leading cause of death from an infectious disease worldwide, partly due to lack effective strategies screen and triage individuals with potential TB. Whole blood RNA signatures have been tested as biomarkers for TB, but failed meet the World Health Organization’s (WHO) optimal target product profiles (TPP). Here, we use sequencing machine-learning investigate utility plasma cell-free (cfRNA) host-response biomarker TB in cohorts Uganda, Vietnam...
Abstract It is now widely recognised that the environment in space activates a diverse set of genes involved regulating fundamental cellular pathways. This includes activation associated with blood homeostasis and erythropoiesis, particular emphasis on those globin chain production. Haemoglobin biology provides an intriguing model for studying omics, as it has been extensively explored at multiple -omic levels, spanning DNA, RNA, protein analyses, both experimental clinical contexts. In this...
Abstract Tuberculosis (TB) remains a leading cause of death from an infectious disease worldwide. This is partly due to lack tools effectively screen and triage individuals with potential TB. Whole blood RNA signatures have been extensively studied as biomarkers for TB, but they failed meet the World Health Organization’s (WHOs) target product profiles (TPPs) non-sputum or diagnostic test. In this study, we investigated utility plasma cell-free (cfRNA) host response biomarker We used...
ABSTRACT Inflammatory syndromes, including those caused by infection, are a major cause of hospital admissions among children and often misdiagnosed because lack advanced molecular diagnostic tools. In this study, we explored the utility circulating cell-free RNA (cfRNA) in plasma as an analyte for differential diagnosis characterization pediatric inflammatory syndromes. We profiled cfRNA 370 samples from patients with range conditions, Kawasaki disease (KD), Multisystem Syndrome Children...
Inflammatory syndromes, including those caused by infection, are a major cause of hospital admissions among children and often misdiagnosed because lack advanced molecular diagnostic tools. In this study, we explored the utility circulating cell-free RNA (cfRNA) in plasma as an analyte for differential diagnosis characterization pediatric inflammatory syndromes. We profiled cfRNA 370 samples from patients with range conditions, Kawasaki disease (KD), multisystem syndrome (MIS-C), viral...
Abstract Allogeneic hematopoietic cell transplantation (HCT) provides effective treatment for hematologic malignancies and immune disorders. Monitoring of post-transplant complications is critical, yet current diagnostic options are limited. Here, we show that cell-free DNA (cfDNA) in blood a highly versatile analyte monitoring the most important occur after HCT: graft-versus-host disease (GVHD), frequent complication HCT; infection; relapse underlying disease; graft failure. We demonstrate...
Abstract Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest tumors in humans. PDAC has an immunosuppressive tumor microenvironment, constituting for poor immunotherapy outcomes. Lymphatic vessels (LVs) transport leukocytes and antigens from peripheries to draining lymph nodes (dLNs) activation anti-tumor immune responses. It is believed that impairment lymphatic function may result delayed ineffective against tumors. In this study, we created a three-dimensional (3D)...
Hematopoietic Stem Cell Transplantation (HSCT) is one of the oldest and most successful immunotherapies. Yet, despite long-standing success in use HSCT for treatment blood cancers severe immune disorders, monitoring post-transplant complications remains a challenge due to lack informative diagnostic tests. Here, we investigate utility cell-free RNA (cfRNA) plasma as liquid biopsy monitor allogeneic recipients during after treatment. We assayed longitudinal samples from 92 by cfRNA sequencing...
MicroRNAs (miRNAs) play an increasingly recognized role in modulating cancer development. Due to their function regulating gene expression, miRNAs can suppress or promote tumorigenesis. miR-379-5p expression is downregulated multiple human cancers, including breast and bladder cancers. However, the mRNAs targeted by that development have not been fully identified. Our goal was identify a whose regulated miR-379-5p, which may contribute cells where reduced. Bioinformatics analysis showed...
Withdrawal Statement The authors have withdrawn their manuscript owing to data from patients who had not been consented being inadvertently used in the preprint. This has corrected version of study published Cell Reports Medicine. Therefore, do wish this work be cited as reference for project. If you any questions, please contact corresponding author.
Withdrawal Statement The authors have withdrawn their manuscript owing to data from patients who had not been consented being inadvertently used in the preprint. This has corrected version of study published Cell Reports Medicine. Therefore, do wish this work be cited as reference for project. If you any questions, please contact corresponding author.