A5071956206- Hematopoietic Stem Cell Transplantation
- SARS-CoV-2 and COVID-19 Research
- T-cell and Retrovirus Studies
- CAR-T cell therapy research
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- Vector-Borne Animal Diseases
- COVID-19 Clinical Research Studies
- Blood groups and transfusion
- Polyomavirus and related diseases
- Platelet Disorders and Treatments
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer Immunotherapy and Biomarkers
- Herpesvirus Infections and Treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Advanced biosensing and bioanalysis techniques
- Vasculitis and related conditions
- Animal Disease Management and Epidemiology
- Autoimmune and Inflammatory Disorders Research
- Pericarditis and Cardiac Tamponade
- Histiocytic Disorders and Treatments
- Protein Degradation and Inhibitors
Sapporo Kosei General Hospital
2023-2025
Hokkaido University
2017-2024
Kisarazu Hospital
2022-2023
Scientific Research WorkS Peer Support Group
2023
Fukushima Medical University
2023
Kyoto Min-iren Asukai Hospital
2023
Kyoto University
2023
Hiroshima University Hospital
2023
Santen (Japan)
2023
Nara Institute of Science and Technology
2021
Adult T-cell leukemia/lymphoma (ATLL) is an aggressive malignancy with a poor prognosis current therapy. Here we report genome-wide CRISPR-Cas9 screening of ATLL models, which identified CDK6, CCND2, BATF3, JUNB, STAT3, and IL10RB as genes that are essential for the proliferation and/or survival cells. As single agent, CDK6 inhibitor palbociclib induced cell cycle arrest apoptosis in models wild-type TP53. had inactivated TP53 genetically were relatively resistant to owing compensatory CDK2...
Adult T-cell leukemia/lymphoma (ATLL) is one of the aggressive peripheral neoplasms with a poor prognosis. Accumulating evidence demonstrates that escape from adaptive immunity hallmark ATLL pathogenesis. However, mechanisms by which cells evade natural killer (NK)-cell-mediated have been poorly understood. Here we show CD48 expression in determines sensitivity for NK-cell-mediated cytotoxicity against cells. We performed unbiased genome-wide clustered regularly interspaced short palindromic...
Data on the response to COVID-19 vaccine in patients with myeloid malignancy, who are at severe risk case of infection, have not emerged. In a study 69 malignancies, including 46 acute leukaemia (AML) and 23 myelodysplastic syndrome (MDS), anti-spike SARS-CoV-2 antibody titres were measured 3 months after second mRNA-based vaccination. Seroconversion rates for AML MDS 94.7% 100% respectively, no significant difference from healthy controls (HCs). Patients showed significantly lower titre...
Serologic responses of COVID-19 vaccine are impaired in patients with B-cell lymphoma, especially those who had recently been treated anti-CD20 monoclonal antibodies. However, it is still unclear whether develop an immune response following vaccination. We investigated the efficacy vaccination against SARS-CoV-2 171 non-Hodgkin lymphoma (B-NHL) received two doses mRNA-based and we compared to that 166 healthy controls. Antibody titers were measured 3 months after administration second dose....
Patients with hematologic diseases have experienced coronavirus disease 2019 (COVID-19) a prolonged, progressive course. Here, we present clinical, pathological, and virological analyses of three cases prolonged COVID-19 among patients undergoing treatment for B-cell lymphoma. These had all been treated anti-CD20 antibody bendamustine. Despite various antiviral treatments, high severe acute respiratory syndrome 2 (SARS-CoV-2) levels persisted >4 weeks, two them succumbed to COVID-19. The...
Abstract Intestinal microbiota plays an important role in the regulation of allogeneic immune reaction after hematopoietic stem cell transplantation (allo‐ SCT ). graft‐vs‐host disease ( GVHD ) is one major causes mortality allo‐ and often complicated with intestinal dysbiosis. Recent studies suggest that antibiotic‐induced dysbiosis a risk factor for . We retrospectively evaluated impacts antibiotic use on incidence occurring before day 100 Among 213 patients who underwent , 200 achieving...
Summary Prolonged SARS‐CoV‐2 infection in immunocompromised individuals has been scattered, but the details remain unclear. We conducted a prospective study with 26 COVID‐19 patients haematological malignancies to determine viral shedding kinetics and characteristics. obtained nasopharyngeal swabs from 21–28 days post‐onset for PCR test performed virus isolation PCR‐positive samples. A viable was detected five (19.2%), all of whom had malignant lymphoma. Those significantly lower CD4 +...
It has been suggested that the effect of coronavirus disease 2019 (COVID-19) booster vaccination in patients with B-cell non-Hodgkin’s lymphoma (B-NHL) is inferior to healthy individuals. However, differences according histological subtype or treatment status are unclear. In addition, there less research on who subsequently develop breakthrough infections. We investigated effects first COVID-19 for B-NHL and clinical features infections Omicron variant era. this study, was classified into...
Benign precursors of B lymphocytes, termed hematogones, are observed in the regenerative state hematopoiesis following chemotherapy or allogeneic hematopoietic stem cell transplantation (allo-HSCT). Previous studies have demonstrated that expansion hematogones correlates with better clinical outcomes after allo-HSCT. We retrospectively analyzed association between and 309 consecutive patients who underwent allo-HSCT, which is largest population-based cohort reported so far. The incidence was...
We have reported that seroconversion rates after the second dose of mRNA-based COVID-19 vaccines for myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) were 100% 95% respectively, with no significant difference from healthy controls (HCs).However, there are very limited data response to a third vaccine in those patients.In this complementary study, we investigated booster effect patients malignancies.A total 58 including 20 MDS 38 AML enrolled. Anti-SARS-CoV-2S immunoassays...
Abstract We herein report a patient who had disseminated toxoplasmosis after hematopoietic stem cell transplantation showing atypical clinical presentation and neuroimaging. Parkinsonism symptoms such as muscle rigidity, bradykinesia, tremor, postural instability were initial manifestations. Magnetic resonance imaging showed diffuse symmetrical lesions of bilateral basal ganglia lacking ringed enhancement. Post‐mortem analysis revealed multiple tachyzoites T oxoplasma gondii in the ganglia,...
Human herpesvirus-6 (HHV-6) reactivation is sometimes observed in immunocompromised patients, especially after allogeneic stem cell transplantation. The complications of HHV-6 this setting are mainly recognized as encephalitis. We herein report the case a patient who developed pneumonitis cord blood transplantation (CBT). A 35-year-old male underwent CBT for T-cell/myeloid mixed phenotype acute leukemia and achieved neutrophil engraftment on day 31. He had received foscarnet prophylaxis...
Abstract Patients with lymphoid malignancies have impaired humoral immunity caused by the disease itself and its treatment, placing them at risk for severe coronavirus disease-19 (COVID-19) reduced response to vaccination. However, data COVID-19 vaccine responses in patients mature T cell NK-cell neoplasms are very limited. In this study of 19 T/NK-cell neoplasms, anti-severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike antibodies were measured 3 months, 6 9 months after...
The standard treatment for colorectal mucosa-associated lymphoid tissue (MALT) lymphoma has not yet been established due to the rarity of disease. Here, we report a case long-term response chemotherapy MALT (stage I). A 77-year-old frail female patient with diabetes mellitus and dementia developed melena unknown etiology, colonoscopy was performed at nearby hospital. biopsy suggested malignant lymphoma, she referred our department. As result re-examination colonoscopy, total 3 submucosal...
POEMS syndrome is often associated with a poor prognosis. Elevated serum vascular endothelial growth factor (sVEGF) useful diagnostic marker high sensitivity and specificity. However, the relationship between sVEGF elevation polyneuropathy in remains controversial. We herein report case of without at first admission. 21 months after onset, patient tested positive for was diagnosed syndrome. Therefore, it important to repeatedly measure levels patients an atypical course when suspected, even...
Histiocytic sarcoma (HS) is a rare aggressive hematological malignancy reported to occur secondary B cell lymphoma. We report case of HS splenic marginal zone lymphoma (SMZL) complicated by autoimmune hemolytic anemia (AIHA) in 64-year-old man. He was referred our department with and diagnosed as having AIHA. After starting treatment prednisolone, atypical lymphocytes appeared his blood tests, bone marrow biopsy revealed invasion A CT scan showed splenomegaly pancreatic mass, which confirmed...
Data for COVID-19 vaccine response in patients with immune thrombocytopenia (ITP) are very limited. In a study of 28 ITP, anti-severe acute respiratory syndrome coronavirus 2 spike antibody titres were measured after vaccination. The seroconversion rate ITP was 91.3%, comparable to that healthy controls (HCs). However, the titre significantly lower than HCs and declined ageing. Furthermore, who received minimum prednisolone dose at least 5 mg/day any time-point or initial vaccination other patients.