A5088781436- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Gut microbiota and health
- Nutrition, Genetics, and Disease
- Nutritional Studies and Diet
- Fatty Acid Research and Health
- Dietary Effects on Health
- Diet, Metabolism, and Disease
- Vitamin D Research Studies
- Nutrition and Health in Aging
- Genetic Associations and Epidemiology
- Obesity, Physical Activity, Diet
- Eating Disorders and Behaviors
- Peroxisome Proliferator-Activated Receptors
- melanin and skin pigmentation
- Advanced Glycation End Products research
- Pancreatic function and diabetes
- Metabolomics and Mass Spectrometry Studies
- Lipid metabolism and disorders
- FOXO transcription factor regulation
- Muscle metabolism and nutrition
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
University of Copenhagen
2010-2020
Nutrition Sciences (Belgium)
2013
Steno Diabetes Centers
2003-2010
Copenhagen University Hospital
2000-2007
Ludwig Cancer Research
1991
Herlev Hospital
1985
Cleveland Metroparks
1951
Altec (United States)
1951
Studies on cell lines have greatly improved our understanding of many important biological questions. Generation is facilitated by the introduction immortalizing oncogenes into types interest. One gene known to immortalize different in vitro encodes simian virus 40 (SV40) large tumor (T) antigen (TAg). To circumvent need for insertion generate lines, we created transgenic mice harboring SV40 TAg gene. Since previous studies shown that expression associated with tumorigenesis and aberrant...
Gut microbial gene richness and specific bacterial species are associated with metabolic risk markers in humans, but the impact of host physiology dietary habits on link between gut microbiota remain unclear. The objective this study was to identify metagenomic estimates insulin resistance, lipid metabolism inflammation obesity, explore whether associations persisted after adjustment for body fat, age habitual intake.Faecal DNA from 53 women obesity analysed through quantitative sequencing...
Individuals with high pre-treatment bacterial Prevotella-to-Bacteroides (P/B) ratio have been reported to lose more body weight on diets in fiber than subjects a low P/B ratio. Therefore, the aim of present study was examine potential differences dietary loss responses between participants and P/B. Eighty overweight were randomized (52 completed) 500 kcal/d energy deficit diet macronutrient composition 30 percentage (E%) fat, 52 E% carbohydrate 18 protein either (≈1500 mg calcium/day) or ( ≤...
The predictive value of sperm motility parameters obtained by computer-assisted semen analysis (CASA) was evaluated for the fertility men from general population. In a prospective study with couples stopping use contraception in order to try conceive, CASA performed on samples 358 men. A recently developed system, Copenhagen Rigshospitalet Image house Motility Analysis System (CRISMAS) used assessment parameters. This system has an editing function which allows correction tracks made...
Mutations in the gene encoding melanocortin 4 receptor (MC4R) are associated with most common monogenic form of obesity. We examined 750 Danish men juvenile-onset obesity (body mass index 33.3 ± 2.4 kg/m2) and 706 control subjects 21.4 2.1 for mutations MC4R. A total 14 different were identified which two, Ala219Val Leu325Phe, novel variants. The variant receptor, was unable to bind [Nle4,d-Phe7]-αMSH, whereas showed a significantly impaired melanotan II induction cAMP, compared wild-type...
The gut microbiota has been implicated in obesity and its progression towards metabolic disease. Dietary interventions that target the have suggested to improve health. aim of present study was investigate effect with Lactobacillus paracasei F19 or flaxseed mucilage on risk markers obesity. A total fifty-eight obese postmenopausal women were randomised a single-blinded, parallel-group intervention 6-week duration, daily intake either L. (9·4 × 10 colony-forming units), (10 g) placebo....
Long-term consumption of dietary fiber is generally considered beneficial for weight management and metabolic health, but the results interventions vary greatly depending on type fibers involved. This study provides a comprehensive evaluation effects specific consisting wheat-bran extract enriched in arabinoxylan-oligosaccharides (AXOS) human intervention trial. An integrated multi-omics analysis has been carried out to evaluate an trial with AXOS-enriched diet overweight individuals indices...
Mutations in the melanocortin 4 receptor gene (MC4R) represent most common known cause of monogenic human obesity.The aims this study were following: 1) to estimate prevalence MC4R mutations obese Czech children; 2) evaluate phenotypic features mutation carriers; 3) compare weight, height, and body mass index carriers with noncarriers longitudinal studies; 4) determine effect a weight management program among 5) perform functional analysis novel variant.We analyzed coding region cohort 289...
Circulating BDNF is higher in women than men and suggested to be affected by changes food intake, body weight, exercise. The purpose of this study was compare concentrations during a 12-week weight loss intervention. Using previously published randomized study, serum assessed at baseline after 12 weeks using an enzyme-linked immunosorbent assay method. Fifty overweight or obese but healthy individuals (26 women, mean age 36.4 ± 7.9 years; 24 men, 38.0 5.9 years) were included allocated into...
To study if genes with common single nucleotide polymorphisms (SNPs) associated obesity-related phenotypes influence weight loss (WL) in obese individuals treated by a hypo-energetic low-fat or high-fat diet.Randomised, parallel, two-arm, open-label multi-centre trial.Eight clinical centres seven European countries.771 adult individuals.10-wk dietary intervention to (-600 kcal/d) diets targeted fat energy of 20%-25% 40%-45%, completed 648 participants.WL during the 10 wk relation genotypes...
Objective This study investigated whether the levels of specific serum microRNAs (miRNAs) were altered following diet‐induced weight loss and miRNAs differed in presence metabolic syndrome. Methods The was a intervention trial with prescribed energy deficit approximately 500 kcal/d. Levels 22 determined samples from 85 participants overweight or obesity. analyzed using TaqMan Array miRNA Cards normalized to geometric mean spiked‐in ath‐miR‐159a U6 small nuclear RNA ΔC T method. Results...
In a longitudinal study including 642 healthy 8-11-year-old Danish children, we investigated associations between vitamin D dependent SNP and serum 25-hydroxyvitamin (25(OH)D) concentrations across school year (August-June). Serum 25(OH)D was measured three times for every child, which approximated measurements in seasons (autumn, winter, spring). Dietary supplement intake, physical activity, BMI parathyroid hormone were likewise at each time point. all, eleven four D-related genes:...