A5082384732- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Complement system in diseases
- Invertebrate Immune Response Mechanisms
- CAR-T cell therapy research
- vaccines and immunoinformatics approaches
- Connexins and lens biology
- Immune Cell Function and Interaction
- Nicotinic Acetylcholine Receptors Study
- Heat shock proteins research
- International Relations in Latin America
University of Chile
2015-2021
Millennium Institute on Immunology and Immunotherapy
2020-2021
Alterations in connexin 43 (Cx43) expression and/or gap junction (GJ)-mediated intercellular communication are implicated cancer pathogenesis. Herein, we have investigated the role of Cx43 melanoma cell proliferation and apoptosis sensitivity vitro, as well metastatic capability tumour growth vivo. Connexin levels, GJ coupling rates were analysed four different human lines. Furthermore, lung metastasis high compared with low Cx43-expressing FMS cells evaluated vivo using a xenograft model....
Background Immune checkpoint blocker (ICB) therapy has shown survival benefits for some patients with cancer. Nevertheless, many individuals remain refractory or acquire resistance to treatment, motivating the exploration of complementary immunotherapies. Accordingly, cancer vaccines offer an attractive alternative. Optimal delivery multiple tumor-associated antigens combined potent adjuvants seems be crucial vaccine effectiveness. Methods Here, a prototype generic melanoma vaccine, named...
Hemocyanins are used as immunomodulators in clinical applications because they induce a strong Th1-biased cell-mediated immunity, which has beneficial effects. They multiligand glycosylated molecules with abundant and complex mannose-rich structures. It remains unclear whether these structures influence hemocyanin-induced immunostimulatory processes human APCs. We have previously shown that hemocyanin glycans from Concholepas concholepas (CCH), Fissurella latimarginata (FLH), Megathura...