Isaac Núñez

ORCID: 0000-0001-8859-9115
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About
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Research Areas
  • SARS-CoV-2 and COVID-19 Research
  • Long-Term Effects of COVID-19
  • COVID-19 Clinical Research Studies
  • Respiratory Support and Mechanisms
  • SARS-CoV-2 detection and testing
  • COVID-19 epidemiological studies
  • Sepsis Diagnosis and Treatment
  • Prostate Cancer Treatment and Research
  • Peripheral Neuropathies and Disorders
  • Cancer, Lipids, and Metabolism
  • Vagus Nerve Stimulation Research
  • HIV/AIDS drug development and treatment
  • HIV/AIDS Research and Interventions
  • Health Systems, Economic Evaluations, Quality of Life
  • COVID-19 and healthcare impacts
  • Bacillus and Francisella bacterial research
  • Non-Invasive Vital Sign Monitoring
  • Poxvirus research and outbreaks
  • Lung Cancer Research Studies
  • COVID-19 diagnosis using AI
  • COVID-19 and Mental Health
  • Radiopharmaceutical Chemistry and Applications
  • Bladder and Urothelial Cancer Treatments
  • Medical Imaging and Pathology Studies
  • Vaccine Coverage and Hesitancy

Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2020-2025

Universidad Nacional Autónoma de México
2023-2025

Karolinska Institutet
2024

Departamento de Educación
2020

Universidad Vasco de Quiroga
2020

Universidad de Sonora
2019

Vall d'Hebron Hospital Universitari
2011-2013

Universitat Autònoma de Barcelona
2013

Human monkeypox, a zoonosis historically endemic to West and South Africa, has led worldwide outbreak driven by human-to-human transmission resulting in an international public health emergency. Endemic monkeypox cases may differ their affected populations, clinical features, outcomes. Thus, profiling of the current is crucial.We performed nationwide observational surveillance-based study from May 24 September 5, 2022. Patients that met operational definition or symptomatic close contacts...

10.1016/j.lana.2022.100392 article EN cc-by-nc-nd The Lancet Regional Health - Americas 2022-11-10

Introduction Few studies have evaluated the presence of Post COVID-19 conditions (PCC) in people from Latin America, a region that has been heavily afflicted by pandemic. In this study, we describe frequency, co-occurrence, predictors, and duration 23 symptoms cohort Mexican patients with PCC. Methods We prospectively enrolled followed adult hospitalized for severe at tertiary care centre Mexico City. The incidence PCC was determined using questionnaires. Unsupervised clustering symptom...

10.3389/fmed.2023.1236702 article EN cc-by Frontiers in Medicine 2023-08-24

Information on Guillain-Barré syndrome (GBS) as an adverse event following immunization (AEFI) against SARS-CoV-2 remains scarce. We aimed to report GBS incidence AEFI among adult (≥18 years) recipients of 81,842,426 doses seven anti-SARS-CoV-2 vaccines between December 24, 2020, and October 29, 2021, in Mexico.Cases were retrospectively collected through passive epidemiological surveillance. The overall observed was calculated according the total number administered doses. Vaccines analyzed...

10.1111/ene.15504 article EN European Journal of Neurology 2022-07-16

Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the causative agent of disease 2019 (COVID-19), may lead to severe systemic inflammatory response, pulmonary damage, and even distress (ARDS). This in turn result failure death. Experimentally, acetylcholine (ACh) modulates a neuro-immune mechanism known as reflex . Recent clinical evidence suggest that electrical chemical stimulation reduce burden inflammation chronic diseases. Pyridostigmine (PDG),...

10.1186/s12879-020-05485-7 article EN cc-by BMC Infectious Diseases 2020-10-16

The COVID-19 pandemic led to the development and emergency approval of an array effective vaccines against SARS-CoV-2. Given relatively small number patients included in vaccine trials, postapproval epidemiological surveillance is crucial detect infrequent vaccine-related adverse events. We conducted a nationwide retrospective descriptive study evaluating incidence seizures among recipients SARS-CoV-2 Mexico from December 24, 2020 (date administration first doses nationwide) October 29,...

10.1111/epi.17390 article EN Epilepsia 2022-08-09

Healthcare saturation has been a prominent worry during the COVID-19 pandemic. Increase of hospital beds with mechanical ventilators central in Mexico's approach, but it is not known whether this actually improves access to care and resulting quality it. This study aimed determine impact healthcare strain other pre-specified variables on dying from coronavirus disease 2019 (COVID-19) without receiving invasive ventilation (IMV).A retrospective cohort was conducted using open data Mexico City...

10.1093/trstmh/trac123 article EN Transactions of the Royal Society of Tropical Medicine and Hygiene 2022-12-23

The aim of this study was to describe the incidence, clinical characteristics, and risk factors late-onset opportunistic infections (LOI) in people who live with HIV (PWLHA) within Caribbean, Central South America network for epidemiology.

10.1016/j.ijid.2022.06.041 article EN cc-by International Journal of Infectious Diseases 2022-06-26

Abstract: Background: Respiratory failure in severe coronavirus disease 2019 (COVID-19) is associated with a inflammatory response. Acetylcholine (ACh) reduces systemic inflammation experimental bacterial and viral infections. Pyridostigmine increases the half-life of endogenous ACh, potentially reducing inflammation. We aimed to determine if pyridostigmine decreases composite outcome invasive mechanical ventilation (IMV) death adult patients COVID-19. Methods: performed double-blinded,...

10.1186/s10020-022-00553-x article EN cc-by Molecular Medicine 2022-11-08

We aimed to determine the effectiveness of switching bictegravir in maintaining an undetectable viral load (<50 copies/mL) among people with HIV (PWH) as compared continuing dolutegravir-, efavirenz-, or raltegravir-based antiretroviral therapy using nationwide observational data from Mexico. emulated 3 target trials comparing vs dolutegravir, efavirenz, raltegravir. Eligibility criteria were PWH aged ≥16 years a <50 copies/mL and at least months current (dolutegravir, raltegravir) between...

10.1093/ofid/ofae446 article EN cc-by Open Forum Infectious Diseases 2024-07-30

Background: Delay in COVID-19 diagnosis due to late real-time reverse transcription-polymerase chain reaction reporting has been described be an important cause of suboptimal surveillance and outbreak containment.Objective:The objective the study was determine duration diagnostic delay test turnaround time its association with marginalization status.Methods: In this observational using national open data Mexico Colombia, we quantified that occurred both countries.We considered two periods...

10.24875/ric.21000542 article EN cc-by-nc-nd Revista de investigaci�n Cl�nica 2022-01-17

Background: Underestimation of the number cases during coronavirus disease 2019 (COVID-19) pandemic has been a constant concern worldwide.Detection severe acute respiratory syndrome 2 (SARS-CoV-2) RNA using realtime reverse-transcription polymerase chain reaction (RT-PCR) is most common method to confirm case.However, these tests have suboptimal sensitivity.Objective: The objective study was estimate COVID-19 confirmed cases, intensive care unit (ICU) admissions and deaths in Mexico,...

10.24875/ric.20000587 article EN cc-by-nc-nd Revista de investigaci�n Cl�nica 2021-03-24

Despite the high number of vaccines administered against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) worldwide, information on psychological/psychiatric adverse events following immunization (AEFI) with these newly developed remains scarce.To describe frequency symptoms among recipients five different anti-SARS-CoV-2 and to explore factors associated their development reported in nationwide Mexican registry AEFI SARS-CoV-2.Descriptive study all symptoms, including anxiety,...

10.3390/vaccines10081297 article EN cc-by Vaccines 2022-08-11

​Background: The development of mRNA vaccines to prevent SARS-CoV-2 has been remarkably successful, with highly effective available less than one year after confirming the first case. Due global burden COVID-19 on health systems, emergency approval was attained clinical trials relatively small sample sizes and short follow-up periods. Limited information exists about incidence adverse events following immunisation (AEFI), particularly neurologic ones. Here, we describe AEFI reported by...

10.2139/ssrn.3816489 article EN SSRN Electronic Journal 2021-01-01
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