A5080104306- Palliative Care and End-of-Life Issues
- Cancer survivorship and care
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Childhood Cancer Survivors' Quality of Life
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Patient Dignity and Privacy
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Medical and Health Sciences Research
- Clinical practice guidelines implementation
- Ethics in medical practice
- Family Support in Illness
- Cancer Diagnosis and Treatment
- Cancer-related cognitive impairment studies
- Biosimilars and Bioanalytical Methods
- Metastasis and carcinoma case studies
- Radioactive Decay and Measurement Techniques
- Statistical Methods in Clinical Trials
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- Music Therapy and Health
- Pain Management and Opioid Use
Essen University Hospital
2016-2025
University of Duisburg-Essen
2011-2025
Ruhrlandklinik
2018-2022
West German Heart and Vascular Center Essen
2003-2021
European Neuroendocrine Tumor Society
2018-2019
Qiagen (Germany)
2019
University Medical Center Hamburg-Eppendorf
2013
University Hospital Ulm
2013
Universität Hamburg
2013
Heinrich Heine University Düsseldorf
2013
BAY 43-9006 is a novel dual-action Raf kinase and vascular endothelial growth factor receptor inhibitor that inhibits tumor cell proliferation angiogenesis. This study established the safety pharmacokinetics of in 69 patients with advanced refractory solid tumors.BAY (50 to 800 mg) was administered once or twice daily on varying weekly schedule. Pharmacokinetic sampling performed all patients; preliminary response also assessed. The effect phorbol myristate acetate-stimulated ERK...
The persistence of circulating tumor cells (CTC) in breast cancer patients might be associated with stem cell like which have been suggested to the active source metastatic spread primary tumors. Furthermore, these also may undergo phenotypic changes, known as epithelial-mesenchymal transition (EMT), allows them travel site metastasis formation without getting affected by conventional treatment. Here we evaluated 226 blood samples 39 during a follow-up palliative chemo-, antibody - or...
Purpose To investigate the safety and tolerability to explore pharmacokinetic pharmacodynamic profile of humanized antiepidermal growth factor receptor monoclonal antibody EMD72000 in patients with solid tumors that express epidermal (EGFR). Patients Methods This was a phase I dose-escalation trial advanced, EGFR-positive, malignancies were not amenable any established chemotherapy or radiotherapy treatment. administered weekly without routine premedication until disease progression...
Abstract Background In order to counteract fatigue, physical activity (PA) is recommended for all stages of cancer. However, only few advanced cancer patients (ACP) are physically active. Quantitative data with high numbers ACP reporting barriers PA missing. This study aimed identify in tiredness/weakness and investigate their motivation towards it. Methods Outpatients metastatic receiving care at a German Cancer Center moderate/severe during self-assessment (MIDOS II) were enrolled. We...
Objective: This study aimed to assess cancer patients' psychological burden during the COVID-19 pandemic by investigating distress (distress-thermometer), health status (EQ-5D-3L), general anxiety (GAD-7), COVID-19-related fear and associated behavioral changes comparing these matched healthy controls, using propensity score matching (PSM). Methods: During first days of in Germany, March 16 30, 2020, 150 actually treated patients controls participated this study. Participants completed an...
The expression of HER2, estrogen (ER) and progesterone (PR) receptor can change during the course disease in breast cancer (BC). Therefore, reassessment these markers at time progression might help to optimize treatment decisions. In this context, characterization circulating tumor cells (CTCs) could be relevance since metastatic tissue may difficult obtain for repeated analysis. Here we compared HER2/ER/PR profiles primary tumors, metastases CTCs.Ninety-six patients with BC from seven...
Liquid biopsies are discussed to provide surrogate markers for therapy stratification and monitoring. We compared messenger RNA (mRNA) profiles of circulating tumor cells (CTCs) extracellular vesicles (EVs) in patients with metastatic breast cancer (MBC) estimate their utility management.Blood was collected from 35 hormone receptor-positive/HER2-negative MBC at the time disease progression 2 consecutive staging points. CTCs were isolated 5 mL blood by positive immunomagnetic selection, EVs 4...
Guidelines recommend a structured symptom screening (SC) for especially advanced cancer patients (CPs). The aim of this multicenter German prospective quality assurance project KeSBa (Kennzahl Symptom- und Belastungserfassung) was to gain knowledge on SC procedures in Oncology Centers (OCs) and first impression the consequences SC.
Background Due to digitization in the medical sector, many healthcare interactions are switched online services. This study assessed acceptance of video consultations (VCs) cancer care, and determined drivers barriers acceptance. Methods A cross-sectional online-based survey was conducted Germany from February 2022 2023. Recruitment took place at oncology outpatient clinics, general practitioners, practices via cancer-related social media channels. Inclusion criteria were a diagnosis,...
The aim of this study was to analyze individual changes in cancer patients’ mental health before and after the COVID-19 outbreak, explore predictors impairment. Over a two-week period (16–30 March 2020), 150 patients Germany participated study. Validated instruments assessed demographic medical data, depression anxiety symptoms (PHQ-2, GAD-2), distress (DT), status (EQ-5D-3L). All were adapted measure outbreak. COVID-19-related fear, trust governmental actions face COVID-19, subjective level...
Circulating tumor cells (CTCs) are thought to be an ideal surrogate marker monitor disease progression in metastatic breast cancer (MBC). We investigated the prediction of treatment response CTCs MBC patients on basis expression 46 genes.From 45 and 20 healthy donors (HD), 2 × 5 mL blood was collected at time (TP0) consecutive clinical staging points (TP1 TP2) proceed with AdnaTest EMT-2/StemCellSelectTM (QIAGEN). Patients were grouped into (a) responder (R) non-responder (NR) TP1 (b)...
Cell-free DNA (cfDNA) is described to mirror intratumoral heterogeneity and gives insight about clonal evolution for improved therapeutic decisions. We sequenced cfDNA of a hormone receptor-positive, HER2-negative metastatic breast cancer (MBC) cohort with high coverage examine the prevalence relevance any detected variant. 44 MBC patients was isolated, followed by library construction using customized targeted panel integrated unique molecular indices analyzing AKT1, AR, BRCA1, BRCA2, EGFR,...
Circulating tumor cells (CTC) are discussed to be an ideal surrogate marker for individualized treatment in metastatic breast cancer (MBC) since tissue is often difficult obtain repeated analysis. We established a nine gene qPCR panel characterize the heterogeneous CTC population MBC patients including epithelial CTC, their receptors (EPCAM, ERBB2, ERBB3, EGFR) Epithelial-Mesenchymal-Transition [(EMT); PIK3CA, AKT2), stem cell-like (ALDH1) as well resistant (ERCC1, AURKA] identify individual...
Abstract Background Single liquid biopsy analytes (LBAs) have been utilized for therapy selection in metastatic breast cancer (MBC). We performed integrative statistical analyses to examine the clinical relevance of using multiple LBAs: matched circulating tumor cell (CTC) mRNA, CTC genomic DNA (gDNA), extracellular vesicle (EV) and cell-free (cfDNA). Methods Blood was drawn from 26 hormone receptor-positive, HER2-negative MBC patients. mRNA EV were analyzed a multi-marker qPCR. Plasma...
The experience of cancer among relatives is characterized by an increase in anxiety and depression, stress, a reduction quality life. However, there paucity psychosocial support programmes for dearth evidence-based, manualized interventions. Accordingly, the present study aims to assess acceptability, defined as participant drop-out satisfaction, feasibility, terms mental health improvement, novel psycho-educational group intervention. manual was developed on basis previous research into...
Background/Objectives: The "Palliative Care and Rapid Emergency Screening Tool" (P-CaRES) is used to identify patients with palliative needs in the emergency department. This study aims translate, adapt, validate P-CaRES tool for German healthcare context. Methods: a monocentric, non-interventional, retrospective conducted department of University Hospital Essen, Germany. After structured translation process, tool's face content validity were evaluated using questionnaires completed by...
3605 Background: Vascular endothelial growth factors (VEGF-A, -B, -C, D and -E) are potent angiogenesis secreted by many solid tumors. PTK/ZK is a novel, oral, small molecule inhibitor that blocks all known VEGF receptor tyrosine kinases, important mediators in the formation of new blood lymph vessels contribute to tumor metastasis. Method: The goal this trial determine maximum tolerated dose (MTD) dose-limiting toxicities (DLTs) once-daily oral combination with infusional 5-fluorouracil...
Liquid biopsy analytes such as cell-free DNA (cfDNA) and circulating tumor cells (CTCs) exhibit great potential for personalized treatment. Since cfDNA CTCs are considered to give additive information blood specimens limited, isolation of CTC in an “all from one tube” format is desired. We investigated whether variant sequencing CTC-depleted (CTC-depl. B; obtained after positive immunomagnetic (AdnaTest EMT-2/Stem Cell Select, QIAGEN)) impacts the results compared matched whole (WB)....
Zusammenfassung In der Palliativversorgung und -forschung gewinnen neue Technologien an Bedeutung. Um dieser Entwicklung Rechnung zu tragen, widmeten sich die Wissenschaftlichen Arbeitstage (WAT) 2024 Deutschen Gesellschaft für Palliativmedizin diesem Thema. Unter den Teilnehmenden wurden zwei Online-Befragungen durchgeführt: eine vor Durchführung WAT weitere nach im Rahmen deren Evaluation. Dabei Technikaffinität Einschätzungen neuen erhoben. Die Daten mit deskriptiver quantitativer...