Taking advantage of the high impermeability property graphene and sharp surface plasmon resonance (SPR) curve silver, we numerically demonstrate that SPR imaging biosensors with a graphene-on-silver substrate can be used to achieve dramatically sensitivity as well prevent silver oxidation. Results our numerical study show few layers significantly increase sensitivity, compared conventional gold-film-based biosensor. In particular, single layered deposited on 60-nm thick film amplifies signal...

Mitochondria are organelles that readily susceptible to temperature elevation. We selectively delivered a coumarin-based fluorescent iron oxide nanoparticle, Mito-CIO, the mitochondria. Upon 740 nm laser irradiation, intracellular of HeLa cells was elevated by 2.1 °C within 5 min when using and treatment resulted in better hyperthermia more cytotoxicity than treated with coumarin (CIO), which missing mitochondrial targeting unit. further confirmed these results tumor xenograft mouse model....

An advanced optical activation of neural tissues is demonstrated using pulsed infrared light and plasmonic gold nanorods. Photothermal effect localized in plasma membrane triggers action potentials vivo tissues. Compared with conventional stimulation, the suggested method can increase a responsivity lower threshold stimulation level significantly, thereby reducing requisite radiant exposure concern tissue damage. As service to our authors readers, this journal provides supporting information...

We have experimentally confirmed sensitivity enhancement of a nanowire-based surface plasmon resonance (SPR) sensor structure. Gold nanowires with periods 200 and 500 nm were fabricated, respectively, by electron-beam interference lithography on gold/SF10 substrate. Sensitivity was measured to be 44% compared conventional thin-film-based SPR structure for period 31% when evaluated using ethanol at varied concentration. This result is consistent numerical data. Surface roughness responsible...

In this study, we investigated the sensitivity enhancement in nanowire-based surface plasmon resonance (SPR) biosensors using rigorous coupled wave analysis (RCWA). The enhancement, enabled by excitation of localized plasmons gold nanowires, offers improved performance as well reproducibility and customizability. Calculation results found that a T-profile provides higher than an inverse general also determined optimum design parameters. Our study on nanowire-enhanced SPR biosensor...

We investigated grating-coupled transmission-type surface plasmon resonance (SPR) for sensing applications. In the SPR structure, propagating plasmons are outcoupled to radiation modes by dielectric and metallic gratings on a metal film. The results calculated in air water suggest that proposed structures present extremely linear characteristics. terms of figure merit, grating-based structure performs 5.4 3.7 times better than grating water, respectively.

Surface plasmon resonance (SPR) sensors based on a silver film suffer from signal degradation due to oxidation in aqueous sensing environments. To overcome this limitation, we fabricated the planar plasmonic substrate employing an atomic MoS2 layer surface. Successful production of large-area monolayer blocks penetration oxygen and water molecules. In addition, theoretically experimentally found that can improve SPR sensitivity stability significantly. study, proposed has potential provide...

A simplified cochlear implant (CI) system would be appropriate for widespread use in developing countries. Here, we describe a CI that have designed to realize such concept. The implements 8 channels of processing and stimulation using the continuous interleaved sampling (CIS) strategy. generic digital signal (DSP) chip is used processing, filtering functions are performed with fast Fourier transform (FFT) microphone or other input. Data derived from transmitted through an inductive link...

Enhanced detection of multiple targets such as self-assembled monolayer (SAM) formation, DNA hybridization, and ethanol ambient changes was explored using localized surface plasmon resonance (LSPR) excited by metallic nanogratings. The sensitivity enhancement depends on the target well nanostructure with a maximum at 242% over conventional structure when detecting an 11-mercaptoundecanoic acid SAM LSPR 200 nm period. measured shows smaller target-dependent variance various layered...

A surface plasmon resonance (SPR) imaging biosensor based on silver substrates was investigated to demonstrate that could be used as a substrate material for sensitive detection of biomolecular interactions, despite its poor chemical stability. The calculation results showed oxidation film may lead decrease in the sensitivity due variation SPR characteristics such broader curve width and shallower minimum reflectance at resonance. effect change refractive index target analytes also explored....

We demonstrate that surface plasmon resonance (SPR) is applicable to the optical detection of neural signals. A low-noise SPR sensor was developed as a label- and artifact-free method for extracellular recording activity. The responses obtained from rat sciatic nerve were highly correlated with simultaneously recorded electrical responses. Additional studies stimulation intensity lidocaine further confirmed optically measured signals originated activities.

A localized surface plasmon resonance (LSPR) biosensor using relief nanostructures was investigated to evaluate the importance of target localization on sensitivity enhancement. The LSPR device modeled as periodic metallic nanowires with a square profile gold film and self-assembled monolayer in buffer solution. numerical results rigorous coupled-wave analysis finite-difference time domain method demonstrated plasmonic fields induced by nanostructure from which effect quantitatively...

A nanowire-mediated surface plasmon resonance (SPR) imaging is numerically investigated for enhanced sensitivity. The results calculated by rigorous coupled-wave analysis present that interplays between localized plasmons and polaritons contribute to sensitivity enhancement. Compared conventional thin film-based SPR measurement, an optimal nanowire structure can provide enhancement 3.44 times as well highly linear detection property quantification of reactions interests. This paper...

Background and Objectives:The incidence of postoperative atrial fibrillation after noncardiothoracic surgery is known to be very rare; there have been few prior studies on this topic.We evaluated the incidence, predictors, prognosis surgery.Subjects Methods: Patients who underwent at our medical center under general anesthesia were enrolled.We reviewed records retrospectively whether developed postoperatively or was pre-existing.Patients had a previous history pre-operative electrocardiogram...

We demonstrated enhanced localized surface plasmon resonance (SPR) biosensing based on subwavelength gold nanoarrays built a thin film. Arrays of nanogratings (1D) and nanoholes (2D) with period 200 nm were fabricated by electron-beam lithography used for the detection avian influenza DNA hybridization. Experimental results showed that both provided significant sensitivity improvement and, especially, 1D exhibited higher SPR signal amplification compared 2D nanohole arrays. The enhancement...

A novel surface plasmon resonance (SPR) detection technique based on the programmed assembly of superparamagnetic iron oxide nanoparticles (SPIONs) and corresponding change in mobility under external magnetic fields was demonstrated. In this approach, SPIONs act as a magnetophoretic switch undergoing aggregation only presence target analytes. The aggregated which were magnetically attracted to metal film create layer over sensor with refractive index contrast, resulting notable SPR angle...

Despite a potential of infrared neural stimulation (INS) for modulating activities, INS suffers from limited light confinement and bulk tissue heating. Here, novel methodology an advanced optical is proposed by combining near-infrared (NIR) with gold nanorods (GNRs) targeted to neuronal cell membrane. We confirmed experimentally that in vitro vivo activation associated local heat generation based on NIR GNRs. Compared the case without aid GNRs, combination cell-targeted GNRs allows...

We have investigated the effect of surface roughness on sensitivity conventional and nanowire-based plasmon resonance (SPR) biosensors. The theoretical research was conducted using rigorous coupled-wave analysis with Gaussian profiles gold films determined by atomic force microscopy. results suggest that, when ranges near 1 nm, a SPR system is not significantly affected regardless correlation length. For biosensor, however, we found that degrades substantially decreasing In particular, at...