A5073654201- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Advanced Memory and Neural Computing
- Neuroscience and Neuropharmacology Research
- Hearing Loss and Rehabilitation
- Molecular Communication and Nanonetworks
- Neurological disorders and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Photoacoustic and Ultrasonic Imaging
- Analytical Chemistry and Sensors
- Ultrasound and Hyperthermia Applications
- Vagus Nerve Stimulation Research
- 3D Printing in Biomedical Research
- Advanced Fluorescence Microscopy Techniques
- Advanced Sensor and Energy Harvesting Materials
- Ultrasound and Cavitation Phenomena
- Hearing, Cochlea, Tinnitus, Genetics
- Neuropeptides and Animal Physiology
- Conducting polymers and applications
- Pain Mechanisms and Treatments
- Olfactory and Sensory Function Studies
- Analog and Mixed-Signal Circuit Design
- Neuroendocrine regulation and behavior
Ewha Womans University
2016-2025
Seoul National University
2003-2025
Ewha Womans University Medical Center
2012-2024
SmartFactory (Germany)
2022
Baewha Women's University
2019
National Institute on Alcohol Abuse and Alcoholism
2011
National Institutes of Health
2009
Yong In University
2007
New York State Department of Health
2005
Wadsworth Center
2005
Docosahexaenoic acid (DHA, 22:6n-3), the major polyunsaturated fatty accumulated in brain during development, has been implicated learning and memory, but underlying cellular mechanisms are not clearly understood. Here, we demonstrate that DHA significantly affects hippocampal neuronal development synaptic function developing hippocampi. In embryonic cultures, supplementation uniquely promoted neurite growth, synapsin puncta formation protein expression, particularly synapsins glutamate...
Abstract Astrocytes can affect animal behavior by regulating tripartite synaptic transmission, yet their influence on affective remains largely unclear. Here we showed that hippocampal astrocyte calcium activity reflects mouse state during virtual elevated plus maze test using two-photon imaging in vivo. Furthermore, optogenetic activation elevating intracellular induced anxiolytic behaviors astrocyte-specific channelrhodopsin 2 (ChR2) transgenic mice (hGFAP-ChR2 mice). As underlying...
An advanced optical activation of neural tissues is demonstrated using pulsed infrared light and plasmonic gold nanorods. Photothermal effect localized in plasma membrane triggers action potentials vivo tissues. Compared with conventional stimulation, the suggested method can increase a responsivity lower threshold stimulation level significantly, thereby reducing requisite radiant exposure concern tissue damage. As service to our authors readers, this journal provides supporting information...
DHA (docosahexaenoic acid, C22:6,n-3) has been shown to promote neurite growth and synaptogenesis in embryonic hippocampal neurons, supporting the importance of known for hippocampus-related learning memory function. In present study, we demonstrate that metabolism DEA (N-docosahexaenoylethanolamide) is a significant mechanism neuronal development, contributing synaptic We found fatty acid amide hydrolase inhibitor URB597 potentiates DHA-induced growth, protein expression. Active was...
A growing body of evidence from both clinical and animal studies indicates that chronic neuropathic pain is associated with comorbid affective disorders. Spinal cord microglial activation involved in nerve injury-induced hypersensitivity characterizing pain. However, thorough assessments the brain after injury are lacking. In present study, we characterized sub-regions CX3CR1GFP/+ mice constriction (CCI) sciatic nerve, including observations at delayed time points when dysfunction such as...
We proposed a method of making flexible depth-type neural probe using liquid crystal polymer. Conventional depth probes made metal or silicon have the limitations single recording site per shank brittleness substrate. To avoid these drawbacks, polymer-based been developed with biocompatible polymers such as polyimides parylenes. However, those suffered from difficulty inserting into brain tissues due to their high flexibility, requiring mechanical reinforcements. Herein, we report first...
A simplified cochlear implant (CI) system would be appropriate for widespread use in developing countries. Here, we describe a CI that have designed to realize such concept. The implements 8 channels of processing and stimulation using the continuous interleaved sampling (CIS) strategy. generic digital signal (DSP) chip is used processing, filtering functions are performed with fast Fourier transform (FFT) microphone or other input. Data derived from transmitted through an inductive link...
We propose an intrinsic optical method for in vivo neural recording using optic fiber-based surface plasmon resonance (SPR) phenomena. The SPR is electrical artifact free, labeling and feasible a portable system compared with conventional systems. simultaneously detected signals activity from the rat somatosensory cortex evoked by stimulation on forepaw. Pharmacological analysis voltage-gated sodium channel blocker confirmed origins of signals. This promises enhanced ability to record...
term reliability of LCP-encapsulation was evaluated by an in vitro accelerated soak test, and possible failure mechanisms were investigated.The could provide reliable electrical insulation for ~400 days 75°C phosphate-buffered solution (PBS).
Despite a potential of infrared neural stimulation (INS) for modulating activities, INS suffers from limited light confinement and bulk tissue heating. Here, novel methodology an advanced optical is proposed by combining near-infrared (NIR) with gold nanorods (GNRs) targeted to neuronal cell membrane. We confirmed experimentally that in vitro vivo activation associated local heat generation based on NIR GNRs. Compared the case without aid GNRs, combination cell-targeted GNRs allows...
The study of the zinc biology requires molecular probes with proper affinity. We developed a low-affinity probe (HBO-ACR) based on an azacrown ether (ACR) and 2-(2-hydroxyphenyl)benzoxazole (HBO) fluorophore. This design imposed positive charge in vicinity coordination center, which enabled fluorescence turn-on responses to high levels without being affected by pH presence other transition-metal ions. Steady-state transient photophysical investigations suggested that such tolerance benefits...
The binding of olfactory receptors with odorant molecules initiates signal transduction, which leads to a cationic influx. In the present study, human embryonic kidney-293 cells were recombinantly engineered co-express I7 and gustatory cyclic nucleotide gated channels, increased odorant-induced change in membrane potential was measured extracellular region using microelectrode arrays. A biphasic electrical current stimulation applied order increase intrinsic cellular activity. Upon odorants...
Objectives In this study, we compared the magnetic resonance (MR) image artifacts caused by a conventional metal-based cochlear implant and newly developed liquid crystal polymer (LCP)-based device. Methods The system (Nurobiosys Co.) was attached to side of head subject LCP-based device opposite side. both devices, alignment magnets were removed for safety. Magnetic imaging (MRI) performed on widely used 3.0 T an ultra-high 7.0 MRI machine. MR images acquired using T1- T2*-weighted gradient...