A5045832006- Vascular Procedures and Complications
- Aortic aneurysm repair treatments
- CAR-T cell therapy research
- Alzheimer's disease research and treatments
- Peripheral Artery Disease Management
- Lipid Membrane Structure and Behavior
- Medical Imaging and Pathology Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Biosimilars and Bioanalytical Methods
- Mechanical Circulatory Support Devices
- Radiomics and Machine Learning in Medical Imaging
- T-cell and B-cell Immunology
- Vascular anomalies and interventions
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Dementia and Cognitive Impairment Research
- Central Venous Catheters and Hemodialysis
- S100 Proteins and Annexins
- Bone health and treatments
- Viral Infectious Diseases and Gene Expression in Insects
- Lymphoma Diagnosis and Treatment
- Infective Endocarditis Diagnosis and Management
- Head and Neck Cancer Studies
- Immune Cell Function and Interaction
- Medical Imaging Techniques and Applications
Friedrich-Alexander-Universität Erlangen-Nürnberg
2015-2024
Universitätsklinikum Erlangen
2018-2023
Abstract Introduction Synaptic dysfunction and degeneration are central events in Alzheimer’s disease (AD) pathophysiology that thought to occur early progression. pathology may be studied by examining protein biomarkers specific for different synaptic elements. We recently showed the dendritic neurogranin (Ng), including endogenous Ng peptide 48 76 (Ng 48–76 ), is markedly increased cerebrospinal fluid (CSF) AD dominant human brain tissue. The aim of this study was characterize plasma CSF...
Abstract Introduction Neuroinflammation and synaptic degeneration are major neuropathological hallmarks in Alzheimer’s disease (AD). Neurogranin YKL-40 cerebrospinal fluid (CSF) newly discovered markers indicating damage microglial activation, respectively. Methods CSF samples from 95 individuals including 39 patients with AD dementia (AD-D), 13 mild cognitive impairment (MCI) due to (MCI-AD), 29 MCI not (MCI-o) 14 non-AD dementias (non-AD-D) were analyzed for neurogranin YKL-40. Results...
To assess the predictive value of multiparametric MRI for treatment response evaluation induction chemo-immunotherapy in locally advanced head and neck squamous cell carcinoma.Twenty-two patients with advanced, histologically confirmed carcinoma who were enrolled prospective multicenter phase II CheckRad-CD8 trial included current analysis. In this unplanned secondary single-center analysis, all received contrast-enhanced at baseline week 4 after single-cycle therapy cisplatin/docetaxel...
Abstract Purpose The necessity of providing endovascular recanalization acutely thrombosed arteriovenous access (AV access) during weekend is questionable, since hemodialysis can alternatively be achieved by temporarily placed non-tunneled central venous catheters (CVC). Interventional therapy AV provided only on weekdays in the study center. This aimed to compare outcomes patients admitted and weekend. Methods A total 355 procedures for performed a single tertiary center from 2007 2017 were...
BACKGROUND: During the past decades, use of vascular closure devices (VCDs) has been established due to increasing number interventions. Of particular concern is perceived risk VCDs for development implant-induced major complications. Therefore, aim this analysis was report variety access side complications after VCDs, and analyze referred factors.METHODS: All cases associated with VCD requiring surgical repair from 2010 2016 were retrospectively analyzed in a single center trial. Systemic...
Hintergrund: CXCL-8 (IL-8) spielt als Chemoattraktant immunkompetenter Zellen im Rahmen inflammatorischer Prozesse, wie sie in Entzündungsherden von Multiple Sklerose (MS) Patienten zu finden sind, eine entscheidende. In Vorarbeiten konnten wir einen reduzierenden Effekt MS-Liquores (MS-CSF) auf das Membranruhepotential (MRP) und die Gap Junction basierte Kopplung (GJK) VON Astrozyten zeigen. Zudem signifikant erhöhten Spiegel IL-8 MS-CSF nachweisen.