A5037602516- Inflammatory Bowel Disease
- IL-33, ST2, and ILC Pathways
- Bone health and treatments
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Immune Cell Function and Interaction
- Cancer, Lipids, and Metabolism
- Mycobacterium research and diagnosis
- Bone and Joint Diseases
- Helicobacter pylori-related gastroenterology studies
- Peroxisome Proliferator-Activated Receptors
- Digestive system and related health
- Immunodeficiency and Autoimmune Disorders
- Cancer Immunotherapy and Biomarkers
- Immune Response and Inflammation
- Bone Metabolism and Diseases
- Whipple's Disease and Interleukins
- Medical Imaging and Pathology Studies
- Cytokine Signaling Pathways and Interactions
- Adipose Tissue and Metabolism
- TGF-β signaling in diseases
- Cancer Research and Treatments
- MRI in cancer diagnosis
- Galectins and Cancer Biology
Universitätsklinikum Erlangen
2017-2023
Friedrich-Alexander-Universität Erlangen-Nürnberg
2015-2022
The molecular mechanism of action the Janus kinase (JAK) inhibitor tofacitinib is poorly understood.
Colorectal cancer [CRC] is one of the most frequent malignancies, but molecular mechanisms driving growth are incompletely understood. We characterised roles cytokine IL-9 and Th9 cells in regulating CRC development.CRC patient samples from AOM/DSS treated mice were analysed for expression IL-9, CD3, PU.1 by FACS analysis immunohistochemistry. citrine reporter mice, knockout GATA3 CD4-Cre conditional studied model. DNA minicircles or hyper-IL-6 used overexpression cytokines vivo. Effects...
The microvascular endothelial network plays an important role in osteogenesis, bone regeneration and tissue engineering. Endothelial progenitor cells (EPCs) display a high angiogenic vasculogenic potential. endothelialization of scaffolds with supports vascularization formation. In addition, EPCs enhance the osteogenic differentiation formation mesenchymal stem (MSCs). This study aimed to investigate impact on hydroxyapatite (HA) beta-tricalcium phosphate (ß-TCP)–fibrin scaffold. Three...
Siglec-15 is a conserved sialic acid-binding Ig-like lectin, which expressed on osteoclasts. Deficiency of leads to an impaired osteoclast development, resulting in mild osteopetrotic phenotype. The role arthritis still largely unclear. To address this, we generated knockout mice and analyzed them mouse model. We could show that directly involved pathologic bone erosion the K/BxN serum-transfer Histological analyses joint destruction provided evidence for significant reduction area numbers...
ABSTRACT Primary tumors are widely associated with an excess in body fat. The role of adipose tissue on tumor cell homing to bone is yet poorly defined. In this study, we aimed assess whether colonization by cells favored adipocyte-rich marrow. We delineated the accompanying alterations microenvironment and established a treatment approach that interferes high fat diet (HFD)-induced metastasis formation. were able show adipocytes affect skeletal growth metastatic model breast cancer male...
Machine learning (ML) algorithms permit the integration of different features into a model to perform classification or regression tasks with an accuracy exceeding its constituents. This protocol describes development ML algorithm predict growth breast cancer bone macrometastases in rat before any abnormalities are observable standard imaging methods. Such can facilitate detection early metastatic disease (i.e., micrometastasis) that is regularly missed during staging examinations. The...
The growth of primary tumors and metastases is associated with excess body fat. In bone metastasis formation, the marrow microenvironment, particularly adipocytes, play a pivotal role as mediators disseminated tumor cells in marrow. aim present study to non-invasively characterize pathophysiologic processes experimental resulting from accelerated progression within adipocyte-rich using multimodal imaging magnetic resonance (MRI) positron emission tomography/computed tomography (PET/CT). To...
Einleitung: Der Hauptmediator für die IL4-induzierte Differenzierung von TH2-Zellen ist der Transkriptionsfaktor GATA-3. Durch Aktivierung Expression pro-inflammatorischen Cytokinen wie IL-6 und IL-13 gilt GATA-3 als Schrittmacher TH2-Zell vermittelten Colitis ulcerosa, eine schwere Verlaufsform chronisch entzündlichen Darmerkrankungen (CED). Ziel dieses Projekts Analyse funktionalen Rolle bei im experimentellen Modell.
Morbus Crohn (MC) ist eine der schweren Verlaufsformen chronisch entzündlichen Darmerkrankungen (CED). Patienten, die an MC leiden, zeigen mukosale Entzündungen, zum Großteil im Ileum lokalisiert sind. Dies kann auf ein gestörtes Gleichgewicht von Effektor T-Zellen und regulatorischen mit einer massiven Beteiligung TH1 TH17 Zellen zurückgeführt werden. T-bet wichtigsten Transkriptionsfaktoren in hoch pathogenen Zellen, Spektrum inflammatorischen Zytokinen wie IFN-γ sekretieren.
Zielsetzung Bei der Bildung von Knochenmetastasen spielen Mikroumgebung des Knochenmarks und Adipozyten als Wachstumsmediatoren eine wichtige Rolle. In dieser Studie haben wir das Wachstum den zugrundeliegenden pathophysiologischen Prozessen mittels multiparametrischer Magnetresonanztomographie (MRT) Positronen-Emissions-Tomographie/Computertomographie (PET/CT) bei adipösen Versuchstieren evaluiert.
Chronisch entzündliche Darmerkrankungen (CED) sind mit einem erhöhten Risiko für die Entwicklung Colitis-assoziierter Colonkarzinome (CAC) verbunden. Insbesondere produzieren dabei T Zellen, welche zu unterschiedlichen Helferzellen ausdifferenzieren können, eine Vielzahl proinflammatorischer Zytokine. Dadurch diese Zellen kritische Mediatoren von Entzündungen, was darauf hindeutet, dass sie auch führende Rolle bei der Entstehung CAC spielen. Kürzlich haben wir PU.1-exprimierende Th9-Zellen...
T cells and T-cell-secreted cytokines play a central role in the pathogenesis of inflammatory bowel diseases. Although several reports have shown that IL-3 secreted by has an important function immunologically mediated diseases like rheumatoid arthritis or lupus erythematodes, its potential contribution to IBD not been investigated so far. The expression receptor (CD123) gut control donors patients with was evaluated qPCR immunohistochemistry. Human peripheral blood CD4+ were incubated vitro...
Machine learning (ML) algorithms permit the integration of different features into a model to perform classification or regression tasks with an accuracy exceeding its constituents. This protocol describes development ML algorithm predict growth breast cancer bone macrometastases in rat before any abnormalities are observable standard imaging methods. Such can facilitate detection early metastatic disease (i.e., micrometastasis) that is regularly missed during staging examinations. The...