A5062489013- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Neurobiology and Insect Physiology Research
- Acute Myeloid Leukemia Research
- Chromosomal and Genetic Variations
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- T-cell and Retrovirus Studies
- Genetics, Aging, and Longevity in Model Organisms
- Copper-based nanomaterials and applications
- Genomics and Phylogenetic Studies
- Cytokine Signaling Pathways and Interactions
- DNA Repair Mechanisms
- NF-κB Signaling Pathways
- Quantum Dots Synthesis And Properties
- Cancer-related gene regulation
- Semiconductor materials and interfaces
- Developmental Biology and Gene Regulation
American University of Beirut
2018-2022
American University of Beirut Medical Center
2019-2020
Max Planck Institute of Biochemistry
2016
German Cancer Research Center
2012
Heidelberg University
1948-2012
University Hospital Heidelberg
2012
Polycomb group (PcG) protein complexes repress transcription by modifying target gene chromatin. In Drosophila, this repression requires association of PcG with cis-regulatory response elements (PREs), but the interactions permitting formation these assemblies are poorly understood. We show that Sfmbt subunit DNA-binding Pho-repressive complex (PhoRC) and Scm canonical Polycomb-repressive 1 (PRC1) directly bind each other through their SAM domains. The 1.9 Å crystal structure...
Abstract Our ability to manage acute myeloid leukemia (AML) is limited by our incomplete understanding of the epigenetic disruption central leukemogenesis, including improper histone methylation. Here we examine 16 H3 genes in 434 primary AML samples and identify Q69H, A26P, R2Q, R8H K27M/I mutations (1.6%), with higher incidence secondary (9%). These occur pre-leukemic hematopoietic stem cells (HSCs) exist major leukemic clones patients. They increase frequency functional HSCs, alter...
Ten-Eleven Translocation (TET) proteins are important epigenetic regulators that play a key role in development and frequently deregulated cancer. Drosophila melanogaster has single homologous Tet gene (dTet) is highly expressed the central nervous system during development. Here, we examined expression pattern of dTet third instar larval CNS discovered its presence specific set glia cells: midline (MG). Moreover, knockdown resulted significant lethality, locomotor dysfunction, alterations...
1 Es wurde der Mahlvorgang bei einem technisch hergestellten ZnSCu-Phosphor verfolgt und die Korngrößenverteilung einzelnen Mahlfraktionen untersucht. Die Abhängigkeit mittleren häufigsten Korngröße von Mahldauer verschiedenen Mahlgeschwindigkeiten in Kurven dargestellt. ergibt sich, daß nach gleichen Mahlzeiten erhaltene mittlere keine einfache Funktion Mahlgeschwindigkeit ist. 2 strebt mit fortschreitender Grenzwert zu, etwa 4 μ liegt. Elektronenmikroskopisch das Auftreten zweier Gruppen...
Ten-eleven translocation (TET) proteins are crucial epigenetic regulators highly conserved in multicellular organisms. TETs' enzymatic function demethylating 5-methyl cytosine DNA is required for proper development and TETs frequently mutated cancer. Recently, Drosophila melanogaster Tet (dTet) was shown to be expressed developing fly brains discovered play an important role brain muscle as well behavior. Furthermore, dTet have different substrate specificity compared with mammals. However,...