A5088444923- T-cell and Retrovirus Studies
- Retinoids in leukemia and cellular processes
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Acute Myeloid Leukemia Research
- Vector-Borne Animal Diseases
- Chronic Myeloid Leukemia Treatments
- Animal Disease Management and Epidemiology
- Chronic Lymphocytic Leukemia Research
- Epigenetics and DNA Methylation
- NF-κB Signaling Pathways
- RNA regulation and disease
- Eosinophilic Disorders and Syndromes
- Antioxidant Activity and Oxidative Stress
- Immune Cell Function and Interaction
- Extracellular vesicles in disease
- Estrogen and related hormone effects
- Ubiquitin and proteasome pathways
- Acute Lymphoblastic Leukemia research
- Effects and risks of endocrine disrupting chemicals
- Gut microbiota and health
- Genomics and Chromatin Dynamics
- Pancreatic and Hepatic Oncology Research
- Protein Degradation and Inhibitors
American University of Beirut
2015-2024
American University of Beirut Medical Center
2018-2023
Prevention Institute
2020
Centre National de la Recherche Scientifique
1999-2011
Hamad Medical Corporation
2011
Université Paris Cité
2006-2011
Assistance Publique – Hôpitaux de Paris
2007-2011
Sorbonne Paris Cité
2011
Inserm
2009-2011
Institut Supérieur de Biotechnologie de Sfax
2011
Chronic HTLV-I (human T cell lymphotropic virus type I) infection may cause adult leukemia/lymphoma (ATL), a disease with dismal long-term prognosis. The transactivator, Tax, initiates ATL in transgenic mice. In this study, we demonstrate that an As2O3 and IFN-α combination, known to trigger Tax proteolysis, cures Tax-driven Unexpectedly, combination therapy abrogated initial leukemia engraftment into secondary recipients, whereas the primary tumor bulk still grew hosts, only ultimately...
Colorectal cancer (CRC) is the second leading cause of deaths worldwide. Stage IV CRC patients have poor prognosis with a five-year survival rate 14%. Liver metastasis main mortality in patients. Since current screening tests several drawbacks, effective stable non-invasive biomarkers such as microRNA (miRNA) are needed. We aim to investigate expression miRNA (miR-21, miR-19a, miR-23a, miR-29a, miR-145, miR-203, miR-155, miR-210, miR-31, and miR-345) plasma 62 Lebanese 44 healthy subjects...
Breast cancer (BC) is the most predominant type of among women. The aim this study to find new biomarkers that can help in early detection BC, especially for those who are too young be screened using mammography as per guidelines. Using microRNA microarray, we previously showed dysregulation 74 microRNAs tumors from BC patients compared with normal adjacent tissues, which were interested studying blood circulation. In study, investigated expression 12...
Workers are exposed to several risks in academic laboratories due the presence of potentially hazardous substances. The main objective this study was assess prevalence accident occurrence and associated risk factors among laboratory workers at scientific public university Lebanon impact safety measures training availability.In observational study, a survey conducted for one year faculties university.Among participants (N = 220), 45.0% have had accidents; cause exposure chemicals (73.7%) more...
Abstract Rhabdomyosarcoma (RMS) is an aggressive childhood soft tissue tumor, which exists in oncoprotein PAX-FOXO1 fusion positive and negative subtypes, with the fusion-positive RMS being characterized by a more clinical behavior. Exosomes are small membranous vesicles secreted into body fluids multiple cell types, including tumor cells, have been implicated metastatic progression through paracrine signaling. We exosomes panel of 5 lines. Expression array analysis showed that, for both...