A5085120488- Synthesis and biological activity
- Crystal structures of chemical compounds
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Computational Drug Discovery Methods
- Metal complexes synthesis and properties
- Enzyme Production and Characterization
- Crystallography and molecular interactions
- Synthesis and Biological Evaluation
- Bioactive Compounds and Antitumor Agents
- Glycosylation and Glycoproteins Research
- Insect Resistance and Genetics
- Cancer therapeutics and mechanisms
- SARS-CoV-2 and COVID-19 Research
- Protein Structure and Dynamics
- Enzyme Structure and Function
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis of Organic Compounds
- Parasitic Diseases Research and Treatment
- Natural Antidiabetic Agents Studies
- Insect symbiosis and bacterial influences
- Mosquito-borne diseases and control
- Genomics, phytochemicals, and oxidative stress
- Ferrocene Chemistry and Applications
- Cholinesterase and Neurodegenerative Diseases
University of Madras
2016-2025
SRM Institute of Science and Technology
2024
Tamil Nadu Agricultural University
2010-2014
Indian Council of Medical Research
2012
Tun Hussein Onn University of Malaysia
2011
University of Alabama at Birmingham
2000-2007
Buffalo State University
1996
University at Buffalo, State University of New York
1996
Universidad Nacional Autónoma de México
1996
A new series of heteroleptic copper(<sc>ii</sc>) complexes with terpyridines and naproxen are reported. The results biological activity laying a foundation for the design anticancer agents.
The world is facing health and economic havoc due to the Corona Virus Disease-2019 (COVID-19) pandemic. Given number of affected people mortality rate, virus undoubtedly a serious threat humanity. By analogy with earlier reports about Severe Acute Respiratory Syndrome (SARS-CoV) Middle East (MERS-CoV) - viruses, novel Coronavirus' replication mechanism likely well understood. structure an endoribonuclease (NSP15) SARS-CoV-2 was reported recently. This enzyme expected play crucial role in...
Recent advances in using biological scaffolds for nanoparticle synthesis have proven to be useful preparing various nanostructures with uniform shape and size. Proteins are significant generating partly because of the presence many functional groups recognize different chemistries. In this endeavor, cocosin protein, an 11S allergen, is prepared from coconut fruit employed as a potential scaffold synthesizing Mn3O4 materials. The interaction between protein manganese ions studied detail...
Favipiravir is found to show excellent in-vitro inhibition activity against Nipah virus. To explore the structure-property relationship of Favipiravir, in silico designing a series piperazine substituted derivatives are attempted and computational screening has been done evaluate its bimolecular interactions with The geometrical features all molecules have addressed from Density Functional Theory calculations. Chemical reactivity descriptor analysis was carried out understand various...
This study assesses the effects of three forms concrete: geopolymer concrete, reactive powder concrete (RPC), and ready-mix (RMC) on environment, economy, sustainability. Evaluating their cost-effectiveness for construction, embodied energy (EE), carbon (EC) is aim. The research method employed involves calculating EE, EC, cost materials used during production stage only. results show that although RMC gives ease at a high emission cost, RPC delivers great strength emissions. Utilizing waste...
9-Alkyl-3,3,6,6-tetramethyl-1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-dione derivatives 2, 3, 4 have been prepared and their absorption, emission laser properties evaluated. A crystal structure determination for the compound 2d has also performed.
Background: Datura stramonium belongs to the family Solanaceae which is commonly dubbed as thorn apple or jimson weed, and abundant throughout tropical subtropical regions. seeds leaves are used anti-asthmatic, antispasmodic, hypnotic narcotic. Externally, in treating fistulas abscesses. It has been by British soldiers treat respiratory problems. also finds its utility Ayurveda for asthma symptoms where weed's smoked cigarette pipe. Objectives: Aim of present study was investigate...
A series of calothrixin B (2) analogues bearing substituents at the 'E' ring and their corresponding deoxygenated quinocarbazoles lacking quinone unit were synthesized. The cytotoxicities calothrixins 1, 2, 15b–p quinocarbazole investigated against nine cancer cell lines. 21a 25a inhibited catalytic activity human topoisomerase II. plasmid DNA cleavage abilities identified compound 15h causing comparable to that (1). Calothrixin (1), 3-fluorocalothrixin 4-fluoroquinocarbazole 21b induced...
New unsymmetrical binuclear nickel(II) complexes [Ni2L(1-5)] (ClO4)2 (1-5) were synthesized by using [NiL] [(3-((9E)-(2-((E)-(3-formyl-2-olato-5-methylbenzylideneamino)methyl) phenylimino)methyl)-3-formyl-5-methyl-2-olato)nickel(II)] with various diamines like 1,2-diaminoethane (L(1)), 1,3-diaminopropane (L(2)), 1,4-diaminobutane (L(3)), 1,2-diaminobenzene (L(4)) and 1,8-diaminonaphthalene (L(5)) characterized elemental analysis spectroscopic methods. The molecular structure of complex 1 is...
Objectives. Biofilm infections caused by S. aureus present a significant threat to human health, leading nosocomial on global scale. To address this critical challenge and explore alternative antibiotic treatments, we investigated the potential of Solanum trilobatum (S. trilobatum), an edible medicinally important herb plant in Ayurvedic medicine.
Multi-antibiotic resistance has become an alarming issue in treating bacterial infections both community and medical environments. Globally, the scientific been exploring multi-antibiotic techniques to find new ways address this challenge. To critical challenge explore alternative antibiotic treatments, we investigated potential of Solanum trilobatum, edible medicinally important herb plant Ayurvedic medicine. Our research focused on a 60 kDa serine protease isolated purified from leaves S....
The structure of the complex between 2,3-diphosphoglycerate-independent phosphoglycerate mutase (iPGM) from<i>Bacillus stearothermophilus</i> and its 3-phosphoglycerate substrate has recently been solved, analysis this allowed formulation a mechanism for iPGM catalysis. In order to obtain further evidence mechanism, we have solved complexed with 2-phosphoglycerate two Mn<sup>2+</sup> ions at 1.7-Å resolution. consists different domains connected by loops interacting through network hydrogen...
In this study the interaction mechanism between newly synthesized 4-(3-acetyl-5-(acetylamino)-2-methyl-2, 3-dihydro-1,3,4-thiadiazole-2-yl) phenyl benzoate (thiadiazole derivative) anticancer active drug with calf thymus DNA was investigated by using various optical spectroscopy techniques along computational technique. The absorption spectrum shows a clear shift in lower wavelength region, which may be due to strong hypochromic effect ctDNA and drug. results of steady state fluorescence...
Protein kinases are ubiquitously expressed as Serine/Threonine kinases, and play a crucial role in cellular activities. have evolved through stringent regulation mechanisms. also involved tauopathy, thus important targets for developing Anti-Alzheimer's disease compounds. Structures with an indole scaffold turned out to be potent new leads. With the aim of inhibitors human protein kinase C, here we report generation four point 3D geometric featured pharmacophore model. In order identify...
The global impact of Alzheimer's disease (AD) necessitates intensive research to find appropriate and effective drugs. Many studies in AD suggested beta-amyloid plaques neurofibrillary tangles-associated tau protein as the key targets for drug development. On other hand, it is proved that triggering Glycogen Synthase Kinase-3β (GSK-3β) also cause AD, therefore, GSK-3β a potential target combat AD. We, this study, investigated ability small molecules inhibit through virtual screening,...