A5015761133- vaccines and immunoinformatics approaches
- Immunotherapy and Immune Responses
- Cervical Cancer and HPV Research
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Healthcare Systems and Practices
- Cancer survivorship and care
- Environmental Toxicology and Ecotoxicology
- Health, Medicine and Society
- Water Quality and Pollution Assessment
- Heavy metals in environment
- Cancer Diagnosis and Treatment
- Clinical practice guidelines implementation
- PI3K/AKT/mTOR signaling in cancer
- Sarcoma Diagnosis and Treatment
- Burn Injury Management and Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- MRI in cancer diagnosis
- Antimicrobial Peptides and Activities
- Cancer Genomics and Diagnostics
- Traumatic Ocular and Foreign Body Injuries
- Vestibular and auditory disorders
- Colorectal and Anal Carcinomas
- Neutropenia and Cancer Infections
- Pediatric health and respiratory diseases
Institut Bergonié
2010-2021
German Cancer Research Center
2012-2020
German Center for Infection Research
2016-2020
Heidelberg University
2012-2020
Inserm
2013-2017
Stockholm University
2015
Columbia Gorge Community College
2014
Université de Bordeaux
2013
Centre Hospitalier Agen - Nérac
2013
Chirurgische Universitätsklinik Heidelberg
2002
<h3>Background</h3> <i>PTEN</i> hamartoma tumour syndrome (PHTS) encompasses several clinical syndromes with germline mutations in the suppressor gene, including Cowden which is characterised by an increased risk of breast and thyroid cancers. Because PHTS rare, data regarding cancer risks genotype–phenotype correlations are limited. The objective this study was to better define respect type location mutations. <h3>Methods</h3> 154 individuals a deleterious mutation were recruited from...
To determine factors associated with early functional decline during first-line chemotherapy in older patients.Patients age ≥ 70 years receiving for cancer were prospectively considered inclusion across 12 centers France. Functional was defined as a decrease of 0.5 points on the Activities Daily Living (ADL) scale between beginning and second cycle. Factors sought from pretreatment abbreviated comprehensive geriatric assessment, including ADL, Instrumental ADL (IADL), Mini-Nutritional...
Knowing whether a protein can be processed and the resulting peptides presented by major histocompatibility complex (MHC) is highly important for immunotherapy design. MHC ligands predicted in silico peptide-MHC class-I binding prediction algorithms. However, performance differs considerably, depending on selected algorithm, type, peptide length. We evaluated of 13 algorithms based affinity data 8- to 11-mer derived from HPV16 E6 E7 proteins most prevalent human leukocyte antigen (HLA)...
Cytomegalovirus (CMV) elicits long-term T-cell immunity of unparalleled strength, which has allowed the development highly protective CMV-based vaccine vectors. Counterintuitively, experimental vaccines encoding a single MHC-I restricted epitope offered better immune protection than those expressing entire proteins, including same epitope. To clarify this conundrum, we generated recombinant murine CMVs (MCMVs) well-characterized epitopes at different positions within viral genes and observed...
Triple-negative breast cancer (TNBC) patients have an increased risk of developing visceral metastases and other primary nonbreast cancers, particularly lung cancer. The differential diagnosis TNBC cancers from organs can be difficult due to lack a standard immunoprofile. We analyzed the diagnostic value estrogen receptor, progesterone human epidermal growth factor thyroid transcription factor-1 (TTF1), Napsin A, mammaglobin, gross cystic disease fluid protein 15 (GCDFP15), Sry-related...
Research has suggested that the prevalence of young women with eating disorders (EDs) is increasing, but determining exact EDs within female student-athlete (FS-A) population difficult. Looking at certain traits may help us to identify their level susceptibility developing an ED.To determine FS-As in relation self-concept, including self-esteem and body image.Cross-sectional study.Athletic training health centers National Collegiate Athletic Association Division I, II, III institutions via...
Abstract For rational design of therapeutic vaccines, detailed knowledge about target epitopes that are endogenously processed and truly presented on infected or transformed cells is essential. Many potential (viral mutation‐derived), at low abundance. Therefore, direct detection these peptides remains a challenge. This study presents method for the isolation LC‐MS 3 ‐based targeted low‐abundant human leukocyte antigen (HLA) class‐I‐presented from cells. Human papillomavirus (HPV) was used...
Immune evasion of tumors poses a major challenge for immunotherapy. For human papillomavirus (HPV)-induced malignancies, multiple immune mechanisms have been described, including altered expression antigen processing machinery (APM) components. These changes can directly influence epitope presentation and thus T-cell responses against tumor cells. To date, the APM had not studied systematically in large array HPV+ samples. Therefore this study, systematic analysis was performed on mRNA...
The EU member countries are currently implementing the Water Framework Directive to promote better water quality and overview of their waters. directive recommends usage bioavailability tools, such as biotic ligand models (BLM), for setting environmental standards (EQS) metals. These mainly calibrated towards a chemistry found in south central parts Europe. However, freshwater Scandinavia often has higher levels DOC (dissolved organic carbon), Fe Al combined with low pH compared In this...
Abstract Background This cross-sectional study aimed to assess the frequency and type of firework-associated acoustic trauma occurring in Germany on New Year’s Eve 2021, despite ban firework sales due COVID-19 pandemic. Materials methods The survey period lasted 7 days, from 28 December 2021 03 January 2022. A questionnaire inquired date, treatment trauma, sex, age patient, whether occurred when lighting or watching fireworks. Hearing impairment was classified according World Health...
Dans le contexte actuel de revendications des patientes, développement techniques préservation la fertilité, et recommandations (inter)nationales, notre étude a pour objectif réaliser un état lieux, concernant l’oncofertilité, chez patientes en âge procréer traitées cancer du sein. Étude rétrospective, unicentrique, analytique, pratiques intervenants l’institut Bergonié (oncologues médicaux, chirurgiens, infirmières d’annonce), face aux moins 37 ans, sein infiltrant non disséminé,...
Abstract For the development of a therapeutic vaccine against human papillomavirus (HPV), viral epitopes bona fide presented on surface HPV-transformed cells need to be identified. The constitutively expressed HPV oncoproteins E6 and E7 represent ideal targets for immunotherapeutic vaccination approaches. However, are low abundant leukocyte antigen (HLA)-restricted, posing challenge developing peptide-based vaccines. identification novel epitopes, in silico HLA-binding prediction was used...
9012 Background: Actual data on prognostic geriatric factors of health outcomes are lacking. We aimed to examine whether a decrease in autonomy for activities daily living (ADL) after first cycle chemotherapy influences elderly cancer pts prognosis, and determine this LoA from range biological evaluation factors. Methods: Pts> 70 years receiving 1st-line cancers were included multicentre prospective study. A was defined as 0.5 or more points the ADL scale between beginning treatment 2nd...
To evaluate the efficacy and toxicity of helical tomotherapy (HT) in management spine chordomas when proton therapy is unavailable or non-feasible.
An announcement procedure is mandatory to obtain accreditation treat cancer patients. Health care professionals in the Aquitaine region evaluated organization of this their institutions and patients' perception, order initiate actions improve structure traceability procedure.Self-assessment approach based on a retrospective study plan comprising three concomitant steps: organizational audit, medical records audit patient experience survey.29 participated study. Heterogeneous organizations...
Abstract Detailed knowledge about T cell epitopes, which are bona fide presented on the surface of human papillomavirus (HPV)-transformed cells, is essential for rational design therapeutic HPV vaccines. affects cellular antigen processing machinery, thus not every epitope derived from viral proteins leukocyte (HLA) molecules. Even epitopes displayed in low abundance. In this study, we developed a highly sensitive nano-UPLC-ESI-MS3 multiple-reaction monitoring mass spectrometry (MS) approach...
Abstract To rationally design therapeutic human papillomavirus (HPV) vaccines, it is important to know which T cell epitopes are present on HPV-transformed cells. HPV affects the cellular antigen processing machinery, thus not every epitope derived from viral proteins necessarily presented by Human Leukocyte Antigen (HLA)-molecules cancer surface. HPV16 has been identified as causative agent in 50% of all cervical cases and approximately 95% extra-cervical mucosal HPV-induced tumors. The...