A5077782852- Head and Neck Cancer Studies
- Nasal Surgery and Airway Studies
- Cancer survivorship and care
- Thyroid Cancer Diagnosis and Treatment
- Sinusitis and nasal conditions
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Oral health in cancer treatment
- Head and Neck Anomalies
- Ear and Head Tumors
- Anesthesia and Pain Management
- Cancer Diagnosis and Treatment
- Reconstructive Facial Surgery Techniques
- Otolaryngology and Infectious Diseases
- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
- Traumatic Ocular and Foreign Body Injuries
- Thyroid and Parathyroid Surgery
- Obstructive Sleep Apnea Research
- Nausea and vomiting management
- Vestibular and auditory disorders
- Burn Injury Management and Outcomes
- Cleft Lip and Palate Research
- Ear Surgery and Otitis Media
- Economic and Financial Impacts of Cancer
BDH-Klinik Hessisch Oldendorf
2021-2024
Jena University Hospital
2012-2024
Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde
2023
Friedrich Schiller University Jena
2012
Abstract Background We validated the new European Organisation for Research and Treatment of Cancer Quality Life Head Neck Module (EORTC QLQ‐HN43). Methods enrolled 812 patients with head neck cancer from 18 countries. Group 1 completed questionnaire before therapy, 3 6 months later. In group 2 (survivors), we determined test–retest reliability using intraclass correlation coefficients (ICC). Internal consistency was assessed Cronbach's Alpha, scale structure confirmatory factor analysis,...
Abstract Head and neck cancer (HNC) patients suffer from a range of health‐related quality life (HRQoL) issues, but little is known about their long‐term HRQoL. This study explored associations between treatment group HRQoL at least 5 years' post‐diagnosis in HNC survivors. In an international cross‐sectional study, survivors completed the European Organization for Research Treatment Cancer (EORTC) core questionnaire (EORTC‐QLQ‐C30) its module (EORTC‐QLQ‐H&N35). Meaningful differences...
Background The prognostic role of circulating tumor cells (CTCs) after induction chemotherapy using docetaxel, cisplatin and fluorouracil (TPF) prior to surgery adjuvant (chemo)radiation in locally advanced oral squamous cell cancer (OSCC) was evaluated. Methods In this prospective study, peripheral blood samples from 40 patients the phase II study TISOC-1 (NCT01108042) with OSCC before, during, treatment were taken. CTCs quantified laser scanning cytometry anti– epithelial adhesion...
Abstract Purpose Surgical complications such as hypoparathyroidism (HPT) or vocal cord palsy are seldom assessed when the quality of life (QOL) in thyroid cancer patients is investigated. The aim this study was to measure QOL difference survivors with and without HPT. Methods Participants for analysis were enrolled 13 countries from a that pilot-tested cancer–specific instrument. They included if they had been diagnosed at least 9 months previously. measured using European Organisation...
The long-term problems of head and neck cancer survivors (HNCS) are not well known. In a cross-sectional international study aimed at exploring the quality life in this population, 1114 HNCS were asked to state their two most serious effects. A clinician recorded responses during face-to-face appointments. list 15 example was provided, but free text field also available. total 1033 responded question. frequent 'dry mouth' (DM) (n = 476; 46%), 'difficulty swallowing/eating' (DSE) 408; 40%),...
The purpose of the study was to pilot-test a questionnaire measuring health-related quality life (QoL) in thyroid cancer patients be used with European Organisation for Research and Treatment Cancer (EORTC) core EORTC QLQ-C30. A provisional 47 items administered treated within last 2 years. Patients were interviewed about time help needed complete questionnaire, whether they found understandable, confusing or annoying. Items kept if fulfilled pre-defined criteria: relevant patients, easy...
Abstract To examine the impact of comorbidity on overall survival ( OS ) in a population‐based study patients with head and neck cancer who were treated between 2009 2011. Data 1094 primary carcinomas without distant metastasis from Thuringian registries evaluated concerning influence patient's characteristics . prior to diagnosis was adapted Charlson Comorbidity CCI ), age‐adjusted ACCI HNCCI simplified score SCS Adult Evaluation–27 ACE ‐27). Most male (80%; median age: 60 years; 50% stage...
Purpose: The aim of this study was to validate the new European Organisation for Research and Treatment Cancer Quality Life Thyroid Module (EORTC QLQ-THY34). Methods: We enrolled 437 thyroid cancer patients from 17 countries. One group (n = 303), undergoing treatment or best supportive care, completed questionnaires at three time points (before therapy [t1], 6 weeks later [t2], months after t2 [t3]). A second (survivors ≥2 years diagnosis, n 134) it a random baseline point 1 week later....
Health economic appraisals often rely on the assessment of health utilities using preference-based measures (PBM). The cancer-specific PBM, European Organisation for Research and Treatment Cancer Quality Life Utility - Core 10 Dimensions (EORTC QLU-C10D), was developed recently, now needs to be validated in various clinical populations.
To analyze the effect of adjuvant oral application honey for treating postoperative pain after tonsillectomy.Single centre prospective cohort study.Two cohorts patients tonsillectomy.56 treated with 8 times per day (honey group), 18 without (control group); baseline analgesia were non-steroidal anti-inflammatory drugs (NSAID) or coxibs; opioids used as pro re nata (PRN) medication; mean age 34.4 ± 13.4 years; 36% women.On first to fifth day, rated their using validated questionnaire...
The aim of this study was to explore what methods should be used determine the minimal important difference (MID) and change (MIC) in scores for European Organisation Research Treatment Cancer Head Neck Module, EORTC QLQ-HN43.In an international multi-centre study, patients with head neck cancer completed QLQ-HN43 before onset treatment (t1), three months after baseline (t2), six (t3). explored determining MID were: (1) group comparisons based on performance status; (2) 0.5 0.3 standard...
Induction chemotherapy (IC) is likely to be effective for biologically distinct subgroups of oral cancer and biomarker development may lead identification those patients.We evaluated immune cell infiltration, stroma formation structure the invasive front as well immunohistochemical expression alpha smooth muscle actin (ASMA), CD163, E-cadherin, N-cadherin, laminin gamma 2 chain in pretreatment biopsy specimens surgical resections after IC 20 patients with locally advanced who were treated a...
Abstract Background This cross-sectional study aimed to assess the frequency and type of firework-associated acoustic trauma occurring in Germany on New Year’s Eve 2021, despite ban firework sales due COVID-19 pandemic. Materials methods The survey period lasted 7 days, from 28 December 2021 03 January 2022. A questionnaire inquired date, treatment trauma, sex, age patient, whether occurred when lighting or watching fireworks. Hearing impairment was classified according World Health...
Early detection and typing of tumors is pressing matter in clinical research with important impacts for prognosis successful treatment. Currently, staining the golden standard histopathology but requires surgical removal tissue. In order to avoid resection non-diseased tissue a non-invasive real-time imaging method required which can be applied ideally intrasurgically. this proceeding combination second harmonic generation (SHG), two photon excited fluorescence (TPEF) coherent anti-Stokes...
Introduction Pain after tonsillectomy (TE) is an unsolved problem in the otorhinolaryngology despite different therapeutic approaches. The effect of a two-hour oral application honey (8 times daily, 20 g each) on postoperative pain was assessed first five days TE with outcome-oriented benchmark project QUIPS (quality improvement therapy).
Abstract Purpose The aim of this study was to explore what methods should be used determine the minimal important difference (MID) and change (MIC) in scores for European Organisation Research Treatment Cancer Head Neck Module, EORTC QLQ-HN43. Methods In an international multi-centre study, patients with head neck cancer completed QLQ-HN43 before onset treatment (t1), three months after baseline (t2), six (t3). explored determining MID were: 1) group comparisons based on performance status;...