A5027604425- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- Advanced MRI Techniques and Applications
- EEG and Brain-Computer Interfaces
- Mental Health Research Topics
- Health, Environment, Cognitive Aging
- Neural and Behavioral Psychology Studies
- Memory and Neural Mechanisms
- Pain Mechanisms and Treatments
- Pain Management and Placebo Effect
- MRI in cancer diagnosis
- Neonatal and fetal brain pathology
- Child and Adolescent Psychosocial and Emotional Development
- Psychosomatic Disorders and Their Treatments
- Health disparities and outcomes
- Epilepsy research and treatment
- Bipolar Disorder and Treatment
- Sensory Analysis and Statistical Methods
- Bone and Joint Diseases
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Schizophrenia research and treatment
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Musculoskeletal pain and rehabilitation
Lifespan
2019-2024
University of Pennsylvania
2018-2024
Children's Hospital of Philadelphia
2022-2024
California University of Pennsylvania
2021-2023
University of Pennsylvania Health System
2022
Johnson & Johnson (United States)
2022
Penn Center for AIDS Research
2021-2022
Stanford University
2021
University of Lausanne
2021
Inserm
2015-2019
A diverse set of white matter connections supports seamless transitions between cognitive states. However, it remains unclear how these guide the temporal progression large-scale brain activity patterns in different Here, we analyze brain's trajectories across a single time point from functional magnetic resonance imaging data acquired during resting state and an n-back working memory task. We find that specific sequences are modulated by load, associated with age, related to task...
Brain iron is vital to multiple aspects of brain function, including oxidative metabolism, myelination, and neurotransmitter synthesis. Atypical concentration in the basal ganglia associated with neurodegenerative disorders aging cognitive deficits. However, normative development adolescence its relationship cognition are less well understood. Here, we address this gap a longitudinal sample 922 humans aged 8–26 years at first visit (M = 15.1, SD 3.72; 336 males, 486 females) up four...
Abstract The Adolescent Brain Cognitive Development Study (ABCD), a 10 year longitudinal neuroimaging study of the largest population based and demographically distributed cohort 9-10 olds (N=11,877), was designed to overcome reproducibility limitations prior child mental health studies. Besides fantastic wealth research opportunities, extremely large size ABCD data set also creates enormous storage, processing, analysis challenges for researchers. To ensure privacy safety, researchers are...
Executive function is a quintessential human capacity that emerges late in development and displays different developmental trends males females. Sex differences executive youth have been linked to vulnerability psychopathology as well behaviors impinge on health, wellbeing, longevity. Yet, the neurobiological basis of these not understood, part due spatiotemporal complexity inherent patterns brain network maturation supporting function. Here we test hypothesis sex impulsivity stem from...
Diffusion weighted imaging (DWI) has advanced our understanding of brain microstructure evolution over development. Recently, the use multi-shell diffusion sequences coincided with advances in modeling signal, such as Neurite Orientation Dispersion and Density Imaging (NODDI) Laplacian-regularized Mean Apparent Propagator MRI (MAPL). However, relative utility recently-developed models for maturation remains sparsely investigated. Additionally, despite evidence that motion artifact is a major...
Adolescence is hypothesized to be a critical period for the development of association cortex. A reduction excitation:inhibition (E:I) ratio hallmark development; however, it has been unclear how assess E:I using noninvasive neuroimaging techniques. Here, we used pharmacological fMRI with GABAergic benzodiazepine challenge empirically generate model based on multivariate patterns functional connectivity. In an independent sample 879 youth (ages 8 22 years), this predicted reductions in...
Abstract The brain is organized into networks at multiple resolutions, or scales, yet studies of functional network development typically focus on a single scale. Here, we derive personalized across 29 scales in large sample youths (n = 693, ages 8–23 years) to identify multi-scale patterns re-organization related neurocognitive development. We found that developmental shifts inter-network coupling reflect and strengthen hierarchy cortical organization. Furthermore, observed scale-dependent...
The functions of the human brain are metabolically expensive and reliant on coupling between cerebral blood flow (CBF) neural activity, yet how this evolves over development remains unexplored. Here, we examine relationship CBF, measured by arterial spin labeling, amplitude low-frequency fluctuations (ALFF) from resting-state magnetic resonance imaging across a sample 831 children (478 females, aged 8-22 years) Philadelphia Neurodevelopmental Cohort. We first use locally weighted regressions...
Prior work has shown that there is substantial interindividual variation in the spatial distribution of functional networks across cerebral cortex, or topography. However, it remains unknown whether are sex differences topography individualized youth. Here, we leveraged an advanced machine learning method (sparsity-regularized non-negative matrix factorization) to define 693 youth (ages 8 23 y) who underwent MRI as part Philadelphia Neurodevelopmental Cohort. Multivariate pattern analysis...
Abstract When fields lack consensus standard methods and accessible ground truths, reproducibility can be more of an ideal than a reality. Such has been the case for functional neuroimaging, where there exists sprawling space tools processing pipelines. We provide critical evaluation impact differences across five independently developed minimal preprocessing pipelines MRI. show that even when handling identical data, inter-pipeline agreement was only moderate, critically shedding light on...
Abstract Functional neuroimaging is an essential tool for neuroscience research. Pre-processing pipelines produce standardized, minimally pre-processed data to support a range of potential analyses. However, post-processing not similarly standardized. While several options exist, they may output from different pre-processing pipelines, have limited documentation, and follow generally accepted organization standards (e.g., Brain Imaging Data Structure (BIDS)). In response, we present XCP-D:...
In this study, we investigated changes in functional connectivity of the brain networks patients with benign epilepsy centrotemporal spikes compared to healthy controls using high-density EEG data collected under eyes-closed resting state condition. source reconstruction was performed exact Low Resolution Electromagnetic Tomography (eLORETA). We (FC) between 84 Brodmann areas lagged phase synchronization (LPS) four frequency bands (δ, θ, α, and β). further computed network degree, clustering...
Many key findings in neuroimaging studies involve similarities between brain maps, but statistical methods used to measure these have varied. Current state-of-the-art comparing observed group-level maps (after averaging intensities at each image location across multiple subjects) against spatial null models of maps. However, typically make strong and potentially unrealistic assumptions, such as covariance stationarity. To address issues, this article we propose using subject-level data a...
There is growing evidence that brain networks are altered in epileptic subjects. In this study, we investigated the functional connectivity and network properties of benign childhood epilepsy with centrotemporal spikes using graph theory. Benign most common form idiopathic young children under age 16 years. High-density EEG data were recorded from patients controls resting state eyes closed. Data preprocessed spike spike-free segments selected for analysis. Phase locking value was calculated...
Benign epilepsy with centrotemporal spikes (BECTS) is the most common idiopathic childhood epilepsy, which often associated developmental disorders in children. In present study, we analyzed resting state EEG spectral changes sensor and source spaces eight BECTS patients compared nine age-matched controls. Using high-resolution scalp data, assessed statistical differences spatial distributions of power spectra cortical sources rhythms five frequency bands: δ (0.5–3.5 Hz), θ (4–8 α (8.5–13 β1...
Socioeconomic status (SES) can impact cognitive performance, including working memory (WM). As executive systems that support WM undergo functional neurodevelopment during adolescence, environmental stressors at both individual and community levels may influence outcomes. Here, we sought to examine how SES the neighborhood family level impacts task-related activation of system adolescence determine whether this effect mediates relationship between performance. To address these questions,...