A5019240552- Metabolomics and Mass Spectrometry Studies
- Advanced Chemical Sensor Technologies
- Air Quality and Health Impacts
- Plant biochemistry and biosynthesis
- Carcinogens and Genotoxicity Assessment
- Pesticide Residue Analysis and Safety
- Porphyrin Metabolism and Disorders
- Porphyrin and Phthalocyanine Chemistry
- Analytical Chemistry and Chromatography
- Safe Handling of Antineoplastic Drugs
- Nuts composition and effects
- Bee Products Chemical Analysis
- Photodynamic Therapy Research Studies
- Health, Environment, Cognitive Aging
- Insect and Pesticide Research
- Botanical Research and Applications
- High Altitude and Hypoxia
- Phytochemicals and Antioxidant Activities
- COVID-19 impact on air quality
- Diabetic Foot Ulcer Assessment and Management
- Analytical chemistry methods development
- Cardiovascular and Diving-Related Complications
- Peanut Plant Research Studies
- Healthcare and Environmental Waste Management
- Synthesis of Tetrazole Derivatives
Istituto Nazionale per l'Assicurazione Contro gli Infortuni sul Lavoro
2007-2025
Sapienza University of Rome
1997-2023
Ospedale Santa Maria
2017
Istituto Superiore di Sanità
2000
University of Rome Tor Vergata
1997
The present paper extrapolates quantitative data for ozone virucidal activity on the basis of available scientific literature a safe and effective use in appropriate cases to explore safety measures developed under stimulus current emergency situation. Ozone is powerful oxidant reacting with organic molecules, therefore has bactericidal, virucidal, fungicidal actions. At same time, it toxic substance, having adverse effects health safety. Its being proposed disinfection workplaces’ public...
Antineoplastic drugs are used to treat cancer, having their therapeutic effect by inhibiting the cell division process. Although cancer cells, due rapid growth, more sensitive toxic effects of chemotherapeutic agents, healthy cells and tissues may also be damaged. Many studies show acute chronic toxicity both in patients treated with chemotherapy exposed workers. In fact, exposure these substances can linked formation different types secondary tumors. The International Agency on Research...
The plastic manufacturing industry has a crucial role in the global economy with significant impact wide range of fields. chemical risk to which workers are potentially exposed is difficult characterize and strictly related both products processes adopted. Among chemicals used, we can cite styrene, phenol, butadiene phthalates, but nano- microplastic particles also be released work environment. In this pilot study, present for first time an NMR-based metabolomic approach assessing urinary...
Abstract Introduction Pyridoxal 5’-phosphate (PLP), the biologically active form of vitamin B6 is involved in 4% cellular enzymatic activities and its deficiency responsible for or contributes to several human diseases. The study underlying mechanisms still infancy requires suitable model organisms. In Drosophila produces chromosome aberrations hallmarks diseases including diabetes cancer. However, effects have never been examined at a metabolic level. Objectives This evaluates changes...
Abstract Health‐care workers handling antineoplastic agents may be exposed to extremely low doses of these drugs. Very sensitive and specific analytical methods are therefore needed for biological monitoring. The aim this study was develop validate a method trace level determination doxorubicin, epirubicin, daunorubicin idarubicin in human urine, using epi‐daunorubicin as an internal standard. Solid‐phase extraction (SPE) used sample preparation. Urine samples were loaded onto Bond Elut C18...
Due to its chemical properties, styrene is largely employed in the manufacturing of several products including rubber, polymers and resins, it particularly suitable for shipbuilding industry purposes. In this context, main exposure occurs occupational settings. Despite widespread use, long-term effects on human health at level are still unclear. The aim pilot study was evaluate changes biomarkers related metabolic oxidative stress profiles urine seventeen shipyard workers non-exposed...
New methodology has been developed for the synthesis of so-called sapphyrins, pentapyrrolic "expanded porphyrins". An efficient approach involving acid-catalyzed condensation 1,19-diunsubstituted a,c-biladienes and 3,4-dialkylpyrrole-2-carbaldehydes eliminates preparation bipyrrolic intermediates allows sapphyrins with an unsymmetrical array peripheral substituents. The β-substitution pattern 2,3,13,17-tetraethyl-7,8,12,18,22,23-hexamethylsapphyrin unambiguously confirmed by single crystal...
Metal carpentry includes a wide range of work activities such as welding and cutting metallic components, use solvents paints. Therefore, the employees in these types are mainly exposed to fumes volatile organic solvents. Here, we present an NMR-based metabolomic approach for assessing urinary profiles workers same company that two different risk factors.
Red beetroot is known to be a health-promoting food. However, little attention placed on intestinal bioactive compound absorption. The aim of the study was assess urinary red juice (RBJ) intake biomarkers and possible differences in RBJ's micronutrient absorption at rest or after physical exercise. This three-armed, single-blind study, involving seven healthy volunteers which were randomly divided into three groups alternatively assigned experimental sessions: RBJ rest, with activity,...
Introduction: In the shipbuilding industry, workers are exposed to a variety of dangerous chemicals, styrene being one them. The International Agency for Research on Cancer classified as chemical belonging group 2A, which means it is probably carcinogenic humans. This study aimed at evaluating oxidative stress effects due occupational exposure and other chemicals. Materials methods: Styrene urinary metabolites, such mandelic acid phenylglyoxylic acid, biomarkers stress, i.e., oxidation...
The metabolic profiling of pistachio (Pistacia vera) aqueous extracts from two different cultivars, namely 'Bianca' and 'Gloria', was monitored over the months May to September employing high field NMR spectroscopy. A large number water-soluble metabolites were assigned by means 1D 2D experiments. change in profiles time allowed development be investigated. Specific temporal trends amino acids, sugars, organic acids other observed analysed multivariate Partial Least Squares (PLS) analysis....
Bacterial canker of Actinidia, caused by the bacterium Pseudomonas syringae pv. actinidiae (Psa), is most serious disease these plants worldwide. Leaves three species namely A. chinensis var. chinensis, deliciosa and arguta, having different degrees tolerance to Psa, were analyzed Nuclear Magnetic Resonance spectroscopy. Aqueous extracts leaves studied several metabolites, classified as organic acids, amino carbohydrates, phenols other identified 1D 2D NMR experiments quantified. The...
This epidemiological study aimed to determine the prevalence and characteristics of second tumors (STs) in patients with bronchopulmonary carcinoids (BCs).Data on neuroendocrine carcinomas (NECs) from AIRTUM registry (1975-2011) were used for analysis. Among 32,325 NECs, we focused our analysis 3,205 (9.9%) affected by BCs. The overall ST number incidence calculated. STs was compared expected cancer healthy Italian population, standardized ratio (SIR) 95% confidence intervals calculated.The...
The objective of this study is to evaluate the effects traffic on human health comparing biomonitoring data measured during COVID-19 lockdown, when restrictions led a 40% reduction in airborne benzene Rome and 36% road traffic, same parameters 2021.Biomonitoring was performed 49 volunteers, determining urinary metabolites most abundant pollutants, such as PAHs, oxidative stress biomarkers by HPLC/MS-MS, 28 elements ICP/MS metabolic phenotypes NMR.Means s-phenylmercaputric acid (SPMA),...
Pecan nuts (Carya illinoinensis (Wangenh.) K. Koch) contain the highest number of phytochemicals all nuts, are a natural source unsaturated fatty acids and other nutrients can be considered an important addition to Mediterranean diet al.though several studies have been carried out on pecans, employing analytical techniques, no systematic study metabolic profile is available in literature. In this study, pecan three different cultivars was analysed by Nuclear Magnetic Resonance Spectroscopy....
The most commonly used antiviral treatment against hepatitis C virus is a combination of direct-acting antivirals (DAAs) and ribavirin (RBV), which leads to shortened duration therapy sustained virologic response until 98%. Nonetheless, several dose-related side effects RBV could limit its applications. This study aims measure the urinary concentration main metabolites in order evaluate drug metabolism ability HCV patients adverse effects, such as anemia, with respect metabolite levels....
Abstract Introduction Metabolomics studies the end products of biological processes ocurring in living systems, based on quantification low molecular weight molecules a specific biofluid to evaluate changes metabolism due endogenous and/or exogenous stimuli. Nuclear magnetic resonance (NMR) has proven be very valuable analytical platform for its ability quali-quantitatively characterize complex mixtures with minimal pretreatment and can applied field occupational medicine. Methods Urine...