A5089275393- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
- Ferroptosis and cancer prognosis
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- Acute Myeloid Leukemia Research
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
- Glioma Diagnosis and Treatment
- Carbon Nanotubes in Composites
- interferon and immune responses
- Supercapacitor Materials and Fabrication
- Chronic Myeloid Leukemia Treatments
- Adipose Tissue and Metabolism
- Graphene research and applications
- MicroRNA in disease regulation
- Eosinophilic Disorders and Syndromes
- Ultrasound and Hyperthermia Applications
- Ubiquitin and proteasome pathways
- Circular RNAs in diseases
- Protein Degradation and Inhibitors
- Cancer Genomics and Diagnostics
- Chronic Lymphocytic Leukemia Research
Northwestern University
2021-2025
Midwestern University
2021-2025
Inner Mongolia University
2024-2025
Huazhong Agricultural University
2015-2022
Guangdong University of Finance
2022
Guangdong University Of Finances and Economics
2022
Northwestern Medicine
2022
Shanghai Normal University
2020
Center of Hubei Cooperative Innovation for Emissions Trading System
2016-2018
Beijing University of Agriculture
2015
For efficient use of metal oxides, such as MnO2 and RuO2, in pseudocapacitors other electrochemical applications, the poor conductivity oxide is a major problem. To tackle problem, we have designed ternary nanocomposite film composed (MnO2), carbon nanotube (CNT), conducting polymer (CP). Each component MnO2/CNT/CP provides unique critical function to achieve optimized properties. The performance evaluated by cyclic voltammetry, constant-current charge/discharge cycling techniques. Specific...
Abstract Although major advances in genomics have initiated an exciting new era of research, a lack information regarding cis -regulatory elements has limited the genetic improvement or manipulation pigs as meat source and biomedical model. Here, we systematically characterize their functions 12 diverse tissues from four pig breeds by adopting similar strategies ENCODE Roadmap Epigenomics projects, which include RNA-seq, ATAC-seq, ChIP-seq. In total, generate 199 datasets identify more than...
The experimental specific capacitance of ruthenium oxide (RuO2) is usually much smaller than the theoretical value due to low electron–proton transport and high rate dependence. Highly conductive nanoporous gold (NPG) can dramatically improve capacitive performance RuO2 when electroplated into NPG. RuO2@NPG electrodes provide fast ionic conduction excellent for dependence charge storage around 1500 F g−1, close RuO2.
Compared to single-walled carbon nanotubes (SWNTs) and more defective multiwalled (MWNTs), the thin few-walled (FWNTs) are believed have extraordinary mechanical properties. However, enhancement of properties in FWNTs-polymer composites has remained elusive. In this study, free-standing (CNTs)/polymer composite films were fabricated with three types (SWNTs, FWNTs, MWNTs) functionalized CNTs. The been investigated. It is observed that Young's modulus only 0.2 wt % FWNTs shows a remarkable...
Abstract Feed efficiency (FE) can be measured by feed conversion ratio (FCR) or residual intake (RFI). In this study, we the FE related phenotypes of 236 castrated purebred Yorkshire boars and selected 10 extreme individuals with high low RFI for transcriptome analysis. We used RNA-seq analyses to determine differential expression genes miRNAs in skeletal muscle. There were 99 differentially expressed identified (q ≤ 0.05). The down-regulated mainly involved mitochondrial energy metabolism,...
Distinct genomic structural variations are found in pediatric high-grade glioma, affecting tumor gene expression.
Muscle-invasive bladder cancers are characterized by their distinct expression of luminal and basal genes, which could be used to predict key clinical features such as disease progression overall survival. Transcriptionally, FOXA1, GATA3, PPARG shown essential for subtype-specific gene regulation subtype switching, while TP63, STAT3, TFAP2 family members critical genes. Despite these advances, the underlying epigenetic mechanisms 3D chromatin architecture responsible in cancer remain...
Purification of high-quality few-walled carbon nanotubes (fWNTs) was developed by slow but selective oxidation in hydrogen peroxide (H2O2) at room temperature. The purity, nanotubes' structure, and thermal stability purified fWNTs were characterized transmission electron microscopy (TEM), Raman spectroscopy, thermogravimetric analysis (TGA), respectively. results showed that could be selectively prolonging the stirring time 30 wt % H2O2 solution. Highly obtained, having a high G/D ratio...
Abstract Feed efficiency (FE) is a highly important economic trait in pig production. Investigating the molecular mechanisms of FE essential for improvement. In this study, skeletal muscle proteome high-FE and low-FE pigs were investigated by iTRAQ approach. A total 1780 proteins identified, among which 124 differentially expressed between high- pigs, with 74 up-regulated 50 down-regulated pigs. Ten randomly selected (DEPs) validated Western blotting quantitative PCR (qPCR). Gene ontology...
Feed efficiency (FE) is essential for pig production. In this study, 300 significantly differentially expressed (DE) transcripts, including 232 annotated genes, 28 cis-natural antisense transcripts (cis-NATs), and 40 long noncoding RNAs (lncRNAs), were identified between the liver of Yorkshire pigs with extremely high low FE. Among these 25 DE lncRNAs correlated 125 genes at a transcriptional level. These enriched primarily in vitamin A (VA), fatty acid, steroid hormone metabolism. VA...
Glioblastoma (GBM) is the most prevalent malignant brain tumor with poor prognosis. Although chromatin intratumoral heterogeneity a characteristic feature of GBM, current studies are conducted at single site. To investigate GBM-specific 3D genome organization and its heterogeneity, we Hi-C experiments in 21 GBM samples from nine patients, along three normal samples. We identified subcompartmentalization interactions specific to as well extensive intertumoral these levels. copy number...
Abstract Alterations in the 3D genome organization have been reported different types of cancer and linked with gene dysregulation progression. However, majority studies were performed using bulk chromatin interaction assays therefore, cannot address heterogeneity clone evolution primary human tumors. In this study, we generated single cell Hi-C ATAC-Seq data a cohort AML patients, comprising samples at disease stages, including diagnosis, remission, relapse. To our knowledge, is first large...
The reported fluorescence from inner shells of double-walled carbon nanotubes (DWCNTs) is an intriguing and potentially useful property. A combination bulk single-molecule methods was used to study the spectroscopy, chemical quenching, mechanical rigidity, abundance, density, TEM images near-IR emitters in DWCNT samples. shell found be weaker than SWCNT by a factor at least 10 000. Observable emission samples attributed impurities.
Feed efficiency (FE) is one of the main factors that determine production costs in pig industry. In this study, RNA Sequencing (RNA-seq) was applied to identify genes and long intergenic non-coding RNAs (lincRNAs) are differentially expressed (DE) adipose tissues Yorkshire pigs with extremely high low FE. total, 147 annotated 18 lincRNAs were identified as DE between high- low-FE pigs. Seventeen significantly correlated 112 at transcriptional level. Gene ontology (GO) analysis revealed...
Feed efficiency (FE) is an important trait affecting costs in swine industry. Investigation on FE-related genes different tissues valuable for molecular breeding. Hypothalamus a convergent and integrated centre multiple nutrient-related signals. The present study identified 363 differentially expressed (DE) 14 DE lincRNAs the hypothalamus of high- low-FE Yorkshire pigs. Furthermore, 983 significantly correlated gene-lincRNA pairs were through weighted correlation network analysis (WGCNA)...
Long intergenic non-coding RNAs (lincRNAs) play essential roles in numerous biological processes and are widely studied. The skeletal muscle is an important tissue that plays role individual movement ability. However, lincRNAs pig muscles largely undiscovered their functions remain elusive. In this study, we assembled transcriptomes using RNA-seq data published previous studies of our laboratory group identified 323 porcine leg muscle. We found these have shorter transcript length, fewer...
Abstract >Emerging evidence indicates that microRNA (miRNA) plays an important role in adipogenesis and disease pathogenesis. To investigate the miRNA involved regulating different periods of adipogenesis, we performed a comprehensive study on microRNAome during stimulation by adipogenic differentiation cocktail C2C12 myoblasts at 0, 2, 4, 7 days using Solexa sequencing technology. In this study, identified 52 differentially expressed (DE) miRNA. Functional annotation indicated target...
miRNAs reportedly participate in various biological processes, such as skeletal muscle proliferation and differentiation. However, the regulation of differentially expressed (DE) their function myogenesis remain unclear. Herein, miRNA expression profiles during C2C12 differentiation were analyzed relation to chromatin states by RNA-seq, ATAC-seq, ChIP-seq. We identified 19 known nine novel at days 0, 1, 2, 4. The was related 113 surrounding open regions defined ATAC-seq peaks. Of these...
Abstract Objective This study aims to clarify the mechanisms underlying transcriptional regulation and regulatory roles of lncRNAs in skeletal muscle cell differentiation. Methods We analysed expression patterns via time‐course RNA‐seq. Then, we further combined ATAC‐seq ChIP‐seq investigate governing differentially expressed (DE) lncRNAs. Weighted correlation network analysis GO were conducted identify transcription factor (TF)‐lncRNA pairs related Results identified 385 DE during C2C12...
SUMMARYSomatic embryogenesis is an important model system for studies on embryo development. In order to gain a better understanding of the molecular mechanisms underlying somatic embryogenesis, RNA-Seq data were generated from non-embryogenic callus, embryogenic embryos, early-germinated and late-germinated embryos Fragaria X ananassa Duch. 'Benihopp'. Totals 21 x 106–34 106 high-quality reads obtained various RNA-seq libraries, with average lengths 87–94 base pairs. A total 81% mapped...