A5057221545- Bacteriophages and microbial interactions
- Herpesvirus Infections and Treatments
- Aquaculture disease management and microbiota
- Invertebrate Immune Response Mechanisms
- Microbial infections and disease research
- Marine Bivalve and Aquaculture Studies
- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- Mycobacterium research and diagnosis
- Dermatology and Skin Diseases
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- Grief, Bereavement, and Mental Health
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 detection and testing
- Zoonotic diseases and public health
- Parvovirus B19 Infection Studies
- Animal Disease Management and Epidemiology
- Sinusitis and nasal conditions
- Respiratory viral infections research
- Viral Infections and Outbreaks Research
- Aquaculture Nutrition and Growth
- Autophagy in Disease and Therapy
- SARS-CoV-2 and COVID-19 Research
- Toxin Mechanisms and Immunotoxins
Flinders University
2016-2025
Marie Curie
2023
Cicely Saunders International
2017-2023
King's College London
2009-2023
University College London
2023
The University of Adelaide
2020
South Australia Pathology
1991-2004
Northwestern University
1999-2003
University of Cambridge
2003
Ag-presenting molecule CD1 and CD1-restricted NKT cells are known to contribute defense against a range of infectious pathogens, including some viruses. cells, distinct subpopulation T have striking rapid effector functions that host defense, production IFN-gamma IL-4, activation NK cells. Consideration the important contributions innate adaptive immunity clearance HSV prompted us investigate role expressing V alpha 14-J 281 TCR in pathogenesis infection. To address this issue, we compared...
Diabetic foot ulcer (DFU) is a serious complication of diabetes mellitus. Antibiotic-resistant Staphylococcus aureus frequently isolated from DFU infections. Bacteriophages (phages) represent an alternative or adjunct treatment to antibiotic therapy. Here we describe the efficacy AB-SA01, cocktail three S. Myoviridae phages, made current good manufacturing practice (cGMP) standards, and which has undergone two phase I clinical trials, in multidrug-resistant (MDR) infections.Wounds...
ABSTRACT Epstein-Barr virus (EBV) glycoprotein gp350/gp220 association with cellular CD21 facilitates virion attachment to B lymphocytes. Membrane fusion requires the additional interaction between gp42 and HLA-DR. This binding is thought catalyze membrane through a further gp85-gp25 (gH-gL) complex. Cell lines expressing but lacking expression of HLA class II molecules are resistant infection by recombinant EBV enhanced green fluorescent protein. Surface HLA-DR, HLA-DP, or HLA-DQ confers...
Mutants of herpes simplex virus (HSV) have been used to show that a variety key genes associated with initiation lytic infection or replication viral DNA are not essential for establishment latency. These observations extended in the present study, which virulent strain HSV type 1 is compromised its ability productively infect neurons under favorable conditions was demonstrate early divergence molecular pathways leading productive and latent infection. Our experimental strategy made unique...
Background Staphylococcus aureus is the most common organism in recalcitrant chronic rhinosinusitis (CRS) and often resistant to traditional antibiotic therapy. Bacteriophages (“phages”) are a potential candidate for new, effective For phages be useful setting CRS, two minimum requirements must presented: (1) against S. biofilms (2) have broad spectrum of activity. This study aimed assess vitro activity phage cocktail (CockTail specific bacteriophage [CT-SA]) panel strains isolated from...
Background Staphylococcus aureus biofilms contribute negatively to a number of chronic conditions, including rhinosinusitis (CRS). With the inherent tolerance biofilm-bound bacteria antibiotics and global problem bacterial antibiotic resistance, need develop novel therapeutics is paramount. Bacteriophage ("phage") therapy has previously shown promise in treating sinonasal S. biofilms. Methods This study investigates long term (20 days) safety topical flushes with bacteriophage suspensions....
Background Treatment of sinonasal bacterial biofilms continues to be a challenge in modern rhinology. This study's objective was assess the safety and efficacy topically applied Cocktail S. aureus specific phage (CTSA) alone combination with ethylenediaminetetraacetic acid (EDTA) for treatment Staphylococcus vivo. Methods Using sheep model sinusitis, frontal sinuses (n = 6 per treatment) were flushed once daily CTSA (2 × 10 plaque forming units [PFU]/mL), or without EDTA (0.075 mg/mL),...
The efficacy of phages in multispecies infections has been poorly examined. vitro lytic efficacies phage cocktails AB-SA01, AB-PA01, which target Staphylococcus aureus and Pseudomonas aeruginosa, respectively, their combination against hosts were evaluated S. P. aeruginosa mixed-species planktonic biofilm cultures. Green fluorescent protein (GFP)-labelled PAO1 mCherry-labelled KUB7 laboratory strains clinical isolates used as bacteria. During real-time monitoring using fluorescence...
Little is known about the response of non-model invertebrates, such as oysters, to virus infection. The vertebrate innate immune system detects virus-derived nucleic acids trigger type I IFN pathway, leading transcription hundreds IFN-stimulated genes (ISGs) that exert antiviral functions. Invertebrates were thought lack pathway based on absence or ISGs encoded in model invertebrate genomes. However, oyster genome encodes many ISGs, including well-described protein viperin. In this study, we...
Abstract Complications of diabetes, such as diabetic foot ulcers (DFUs), are common, multifactorial in origin, and costly to treat. DFUs the cause nearly 90% limb amputations among persons with diabetes. In most chronic infections DFU, biofilms involved. Bacteria 100–1000 times more resistant antibiotics than their planktonic counterparts. Multidrug-resistant (MDR) Staphylococcus aureus Pseudomonas aeruginosa may require alternative therapeutic agents bacteriophages ("phages"). This study...
Epstein–Barr virus (EBV) is a human herpesvirus that efficiently transforms and immortalizes primary B lymphocytes. In this study, the role of latent membrane protein 2 (LMP2) in EBV growth transformation was investigated. LMP2 virally encoded expressed EBV-immortalized cells previously shown to be nonessential for transformation. However, recent study reported may an important determinant efficient cell (Brielmeier et al. , Journal General Virology 77, 2807–2818, 1996). deletion mutation...
As viruses are extremely abundant in oceans, marine organisms may have evolved novel metabolites to protect themselves from viral infection. This research examined a well-known commercial gastropod, abalone (Haliotidae), which Australia recently experienced disease due neurotropic infection, ganglioneuritis, caused by an herpesvirus (AbHV). Due the lack of molluscan cell lines for culturing AbHV, antiviral activity Haliotis laevigata was assessed against another herpesvirus, herpes simplex...