A5065613978- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Mechanical Circulatory Support Devices
- Blood Pressure and Hypertension Studies
- Cardiac Arrhythmias and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Heart Failure Treatment and Management
- Cardiac Structural Anomalies and Repair
- Vitamin K Research Studies
- Cardiac tumors and thrombi
- Pharmaceutical Practices and Patient Outcomes
- Medication Adherence and Compliance
- Acute Ischemic Stroke Management
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Health Systems, Economic Evaluations, Quality of Life
- Statistical Methods in Clinical Trials
- Multiple Myeloma Research and Treatments
- Cardiovascular Issues in Pregnancy
- Pharmacovigilance and Adverse Drug Reactions
- Reproductive Health and Contraception
- Acne and Rosacea Treatments and Effects
- Antioxidant Activity and Oxidative Stress
- Chemotherapy-related skin toxicity
Leiden University Medical Center
2016-2025
Aarhus University Hospital
2019-2025
Leiden University
2025
Universitätsklinikum Würzburg
2025
University of Naples Federico II
2023
Josep Carreras Leukaemia Research Institute
2023
Donauspital
2023
Amsterdam University Medical Centers
2021-2022
University of Amsterdam
2021
Haga Hospital
2019-2020
Background: Patients with atrial fibrillation generally require anticoagulant therapy and, at times, additional platelet aggregation inhibitors. Data are scarce on bleeding rates in high-risk groups receiving combination therapy, such as the elderly or patients a high CHA 2 DS -VASc score. Methods: We conducted nationwide cohort study of Danish ≥50 years age. Treatments were ascertained from prescription database. These included no treatment, and treatment vitamin K antagonists, direct oral...
Abstract Background and Aims Coexisting atrial fibrillation (AF) cancer challenge the management of both. The aim study is to comprehensively provide epidemiology coexisting AF cancer. Methods Using Dutch nationwide statistics, individuals with incident (n = 320 139) or 472 745) were identified during period 2015–19. inhabitants without a history 135) 741) matched as control cohorts by demographic characteristics. Prevalence cancer/AF at baseline, 1-year risk diagnosis, their time trends...
To examine the association between use of commonly prescribed psychotropic medications and road traffic accident risk.A record-linkage database was used to perform a case-control study in The Netherlands. data came from three sources: pharmacy prescription data, police driving licence data. Cases were defined as drivers, who had that required medical assistance 2000 2007. Controls adults, no during period. Four controls matched for each case. following medicine groups examined:...
Abstract Purpose A hallmark of acute respiratory distress syndrome (ARDS) is hypoxaemic failure due to pulmonary vascular hyperpermeability. The tyrosine kinase inhibitor imatinib reversed capillary leak in preclinical studies and improved clinical outcomes hospitalized COVID-19 patients. We investigated the effect intravenous (IV) on edema ARDS. Methods This was a multicenter, randomized, double-blind, placebo-controlled trial. Invasively ventilated patients with moderate-to-severe ARDS...
Essential information regarding efficacy and safety of vitamin K-antagonists (VKA) treatment for atrial fibrillation (AF) in non-dialysis dependent chronic kidney disease (CKD) is still lacking current literature. The aim our study was to compare the risks stroke or transient ischemic attack (TIA) major bleeds between patients without CKD (eGFR >60 ml/min), those with moderate 30-60 severe <30 ml/min).We included 300 CKD, 294 moderate, 130 who were matched age sex. Uni- multivariate Cox...
Because practice-based data on the usage of idarucizumab for urgent dabigatran reversal is unavailable, we evaluated appropriateness usage, its haemostatic effectiveness and clinical outcomes.An observational cohort study was performed including consecutive patients who were treated with between 2016 2018. Appropriate assessed predefined criteria. Post-reversal according to International Society Thrombosis Haemostasis (ISTH) recommendations. Patients followed 90 days occurrence...
In contrast to vitamin K antagonists (VKA), direct oral anticoagulants (DOAC's) are not strictly monitored and dose titrated by anticoagulation clinics in the Netherlands. This may affect drug persistence of atrial fibrillation (AF) patients, whom often require lifelong treatment.
Literature shows that atrial fibrillation (AF) patients with a history of cancer have higher risk thromboembolism (TE) and major bleeding (MB) compared to without. However, type time between AF diagnosis is often lacking in such analyses. To examine MB TE rates prior diagnosis, stratified by interval diagnosis. This Danish population-based cohort study included all aged ≥50 years incident January 1, 1995, December 31, 2016, identified those who had before the From hospital drug prescription...
Anticoagulant management of patients with atrial fibrillation active cancer is complex because increases the risk thrombosis as well bleeding. Previous studies have investigated impact any type cancer, while outcomes may differ per specific type. We performed present study to provide more insight into types on clinical outcomes. examined major bleeding (MB) and thromboembolism (TE) rates associated antithrombotic treatment in fibrillation/flutter (AF) who develop whether affected MB TE...
The elevated health burden of thromboembolic events necessitates development blood-based risk monitoring tools. We explored the potential mass spectrometry-based plasma proteomics to provide insights into underlying protein signatures associated with treatment and occurrence events. Utilizing a high-throughput, data-independent acquisition, discovery-based workflow, we analyzed 434 proteomes from different groups individuals events, including I) on vitamin K antagonists (VKAs; n = 130), II)...
Epidemiology of pulmonary embolism (PE) may have shifted since the coronavirus disease 2019 (COVID-19) pandemic. This study aimed to describe temporal trends in PE epidemiology Netherlands 2015. Using nationwide data from Statistics Netherlands, all Dutch inhabitants (>16 million) without a history were dynamically identified on 1 January each year assemble eight cohorts PE-free 2015-22. They individually followed until end that respective determine 1-year risk (identified by hospital...
Abstract Background: Even with considerable advancements in multiple myeloma (MM) therapy, proteasome inhibitors (PIs) continue to be an indispensable treatment pillar MM. However, the development of PI resistance remains a significant clinical challenge. Previous studies proposed different causes contributing PI-resistance, though, these mechanisms explain only subset cases. Hence, we employed multi-omics approach identify further molecular pathways underlying Methods: We applied proteomic...
Abstract Background: The treatment landscape in Multiple Myeloma (MM) shifts towards immunotherapies with the G protein-coupled receptor class C group 5 member D (GPRC5D) as a promising antigen for T cell engagers (TCE) and investigational CART constructs. Monoallelic genetic alterations GPRC5D are present up to 15% of MM patients prior directed therapy. incidence acquired biallelic events following has be determined. Recently, loss was identified underlying mechanism resistance toward...
Bridging with low-molecular-weight heparin (LMWH) is recommended in continuous-flow left ventricular assist device (CF-LVAD) patients during subtherapeutic international normalized ratios (INRs). We aimed to assess the risk of adverse events bridging implanted at Leiden University Medical Center between 2010 and 2024. Incidence rates hazard major bleeding, thromboembolic events, neurologic complications, death 95% confidence intervals (95% CI) were estimated by time-dependent Cox regression....
Many patients who used vitamin K antagonists (VKAs) for long-term prevention of thromboembolism are now actively switched to a direct oral anticoagulant (DOAC). Strict adherence DOAC is crucial its success. However, therapy and clinical factors that predict nonadherence currently not well studied among from VKA DOAC.
Introduction Patients with a first venous thromboembolism (VTE) are at risk of recurrence. Recurrent VTE (rVTE) can be prevented by extended anticoagulant therapy, but this comes the cost an increased bleeding. It is still uncertain whether patients intermediate recurrence or high and bleeding will benefit from treatment, strategy where duration tailored on predicted risks rVTE improve outcomes. The aim Leiden Thrombosis Recurrence Risk Prevention (L-TRRiP) study to evaluate outcomes...
Private pharmacies in Hanoi, Viet Nam.To explore the response of health care providers (HCPs) private to suspected tuberculosis (TB) patients.A simulated patient method combined with an interview 128 randomly selected and 10 near TB hospitals.In interview, respectively 59 (46%) 70 (55%) HCPs referred suspect general care. Only 11 (9%) a facility. Fifty-two (42%) identified from fictitious case described on paper; 34 (27%) were aware that free treatment was provided under National...
Statins are said to protect against a wide range of diseases. We studied what extent potential bias influences the results studies on beneficial side effects statins. selected 8,188 atrial fibrillation patients who started treatment with anticoagulants at Leiden Anticoagulation Clinic in Netherlands between 2003 and 2009 experienced 1,683 minor 451 major bleeds during 18,105 person-years follow-up. were associated risk reduction 9% for (hazard ratio = 0.91, 95% confidence interval: 0.82,...