A5058548647- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Chronic Lymphocytic Leukemia Research
- Histone Deacetylase Inhibitors Research
- Mitochondrial Function and Pathology
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Peptidase Inhibition and Analysis
- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Ubiquitin and proteasome pathways
- Drug Transport and Resistance Mechanisms
- Advanced Proteomics Techniques and Applications
- Metabolism, Diabetes, and Cancer
- PI3K/AKT/mTOR signaling in cancer
- NF-κB Signaling Pathways
University of Verona
2016-2025
Universidade Federal de Alfenas
2019
Institute for Biomedicine
2017
Zero to Three
2009
Charles University
2007
Instituto de Química Física Blas Cabrera
2006-2007
Czech Academy of Sciences, Institute of Biophysics
2007
Czech Academy of Sciences, Institute of Animal Physiology and Genetics
2007
GlaxoSmithKline (Italy)
2005
European Institute of Oncology
2005
Gemcitabine (GEM, 2′,2′-difluorodeoxycytidine) is currently used in advanced pancreatic adenocarcinoma, with a response rate of < 20%. The purpose our work was to improve GEM activity by addition cannabinoids. Here, we show that induces both cannabinoid receptor-1 (CB1) and receptor-2 (CB2) receptors an NF-κB-dependent mechanism its association cannabinoids synergistically inhibits adenocarcinoma cell growth increases reactive oxygen species (ROS) induced single treatments. antiproliferative...
The anti-tumoral effects of cannabinoids have been described in different tumor systems, including pancreatic adenocarcinoma, but their mechanism action remains unclear. We used specific for the CB1 (ACPA) and CB2 (GW) receptors metabolomic analyses to unravel potential pathways mediating cannabinoid-dependent inhibition cancer cell growth. Panc1 cells treated with show elevated AMPK activation induced by a ROS-dependent increase AMP/ATP ratio. ROS promote nuclear translocation GAPDH, which...