A5083759190- Calpain Protease Function and Regulation
- Vasculitis and related conditions
- Pneumocystis jirovecii pneumonia detection and treatment
- Bacterial Infections and Vaccines
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Melanoma and MAPK Pathways
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Renal Diseases and Glomerulopathies
- COVID-19 Impact on Reproduction
- Signaling Pathways in Disease
- Nephrotoxicity and Medicinal Plants
- interferon and immune responses
- Sarcoidosis and Beryllium Toxicity Research
- Pediatric Urology and Nephrology Studies
- Abdominal vascular conditions and treatments
- Organ Donation and Transplantation
- Fungal Infections and Studies
- Infectious Disease Case Reports and Treatments
- Bone health and treatments
- Renal and Vascular Pathologies
- Parathyroid Disorders and Treatments
- Cytomegalovirus and herpesvirus research
- Otitis Media and Relapsing Polychondritis
- Vibrio bacteria research studies
Hospices Civils de Lyon
2019-2023
Hôpital Edouard Herriot
2021-2023
HCL Technologies (India)
2023
Sorbonne Université
2011-2015
Inserm
2011-2015
Délégation Paris 5
2014
Hôpital Européen
2012-2014
Hôpital Européen Georges-Pompidou
2014
Université Paris Cité
2014
Centre National de la Recherche Scientifique
2011
Transplant recipients, who receive therapeutic immunosuppression to prevent graft rejection, are characterized by high coronavirus disease 2019 (COVID-19)-related mortality and defective response vaccines. We observed that previous infection with severe acute respiratory syndrome 2 (SARS-CoV-2), but not the standard two-dose regimen of vaccination, provided protection against symptomatic COVID-19 in kidney transplant recipients. therefore compared cellular humoral immune responses these two...
Sepsis, a leading cause of death worldwide, involves widespread activation inflammation, massive coagulation, and lymphocyte apoptosis. Calpains, calcium-activated cysteine proteases, have been shown to increase inflammatory reactions Moreover, calpain plays an essential role in microparticle release.We investigated the contribution eliciting tissue damage during sepsis.To test our hypothesis, we induced polymicrobial sepsis by cecal ligation puncture wild-type (WT) mice transgenic...
Kidney transplant recipients develop atypical infections in their epidemiology, presentation and outcome. Among these, meningitis meningoencephalitis require urgent adapted anti-infectious therapy, but published data is scarce KTRs. The aim of this study was to describe outcome, order improve diagnostic management. We performed a retrospective, multicentric cohort 15 French hospitals that included all 199 cases M/ME KTRs between 2007 2018 (0.9 case per 1,000 annually). Epidemiology different...
Calpains, calcium-activated proteases, mediate the angiogenic signals of vascular endothelial growth factor. However, their involvement in repair has not been investigated and underlying mechanisms remain to be fully elucidated.A rapidly progressive form glomerulonephritis wild type transgenic mice expressing high levels calpastatin, a calpain-specific inhibitor, was studied. Calpastatin transgene expression prevented peritubular capillaries recovery renal function, limiting mouse survival....
Calpains are intracellular proteases that play a key role in inflammation/immunity. Rare studies show they partially externalized. However, the mechanism of this secretion and functions exteriorized calpains remain poorly understood. In study, we found mouse human lymphocytes secreted through an ABCA1-driven process. turn, extracellular inhibited IL-17A expression. We were able to attribute function cleavage TLR2 domain, which prevented TLR2-induced transcription molecules essential for...
Informing kidney transplant recipients of their prognosis and disease progression is primary importance in a patient-centred vision care. By participating decisions from the outset, may be more adherent to complex medical regimens due enhanced understanding.We proposed include repeated measurements serum creatinine (SCr), addition baseline characteristics, order obtain dynamic predictions graft failure risk that could updated continuously during patient follow-up. Adult French Données...
lyzing group A streptococci, notably without prior drug intake.Again, intraoral pustules were observed.During this episode, clinical and histologic findings consistent with GPP. 1 The patient recalled a similar episode 20 years before generalized pustular eruption systemic symptoms intake.The was given oral clarithromycin (500 mg twice daily) for his throat infection 2 infusions infliximab (5 mg/kg of body weight), which resulted in rapid clearance the lesions.Discussion | Our presented...
Abstract Transplant recipients, which receive therapeutic immunosuppression to prevent graft rejection, are characterized by high COVID-19-related mortality and defective response vaccines. Having observed that previous infection SARS-CoV-2 but not the standard “2 doses” scheme of vaccination, provided complete protection against COVID-19 transplant we undertook this translational study compare cellular humoral immune responses these 2 groups patients. Neutralizing anti-Receptor Binding...
Little is known regarding the optimal management of nocardiosis among solid organ transplant (SOT) recipients. It often suggested to avoid trimethoprim/sulfamethoxazole (TMP-SMX) monotherapy in heavily immunocompromised patients (such as SOT recipients) and/or case severe or disseminated nocardiosis. Our aim was report our experience with TMP-SMX recipients nocardiosis.Using data from a previously published European study, we assessed incidence adverse events receiving and its...
Abstract Background and Aims Outcomes of kidney transplantation for patients with renal AA amyloidosis are uncertain, reports poor survival high allograft recurrence. However, recent advances in biotherapies, especially anti-IL-1 treatments, may have improved patients’ outcome the setting. Method We conducted a retrospective multicenter matched cohort study 26 French centers reporting all who received transplant between 2008 2018, compared them to control (ratio 1:2 controls) other causes...
Abstract Background Mineral bone disorders associated to chronic kidney disease (CKD-MBD) frequently persist after renal transplantation (R-Tx), being due pre-existing CKD-MBD, immunosuppressive therapies and post-Tx hypophosphatemia. We aimed evaluate biomarkers microarchitecture at the time of 6 months R-Tx. Methods Here we present single-center sub-group patients included between 10 18 years age from prospective TRANSOS study (NCT02729142). Patients undergoing a first R-Tx were matched on...
Abstract Background The management of meningitis requires the prompt introduction high-dose probabilistic anti-infectious therapy. literature reporting on in kidney transplant recipients (KTR) is scarce and no recommendation exists for this specific population. Methods We retrospectively included all adult KTRs diagnosed with (cerebro-spinal fluid (CSF) cell count >10/mm3 or positive fungal antigen direct examination) between 2007 2018 16 French hospitals. Clinical, biological,...