A5007718439- Lymphoma Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- CNS Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Multiple Myeloma Research and Treatments
- Viral-associated cancers and disorders
- Acute Lymphoblastic Leukemia research
- Cancer Immunotherapy and Biomarkers
- Polyomavirus and related diseases
- Parvovirus B19 Infection Studies
- Mesenchymal stem cell research
- Histone Deacetylase Inhibitors Research
- Cancer Treatment and Pharmacology
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Peptidase Inhibition and Analysis
- Oral health in cancer treatment
- Autoimmune and Inflammatory Disorders Research
- Gastrointestinal Tumor Research and Treatment
- Vascular Tumors and Angiosarcomas
- Nausea and vomiting management
- Pathogenesis and Treatment of Hiccups
- Childhood Cancer Survivors' Quality of Life
West China Hospital of Sichuan University
2014-2025
Sichuan University
2014-2025
West China Medical Center of Sichuan University
2025
State Key Laboratory of Biotherapy
2022-2024
Palmetto Hematology Oncology
2013
Wuhan University
2007
For classical Hodgkin lymphoma (cHL), programmed death-l (PD-1) is a well-recognized attractive target. This multicenter, single-arm, phase II study evaluated the efficacy and safety of camrelizumab, humanized high-affinity IgG4 mAb against PD-1, in Chinese patients with relapsed or refractory cHL.Patients who had failed to achieve remission experienced progression after autologous stem cell transplantation received at least two lines systemic chemotherapies were given camrelizumab 200 mg...
We report the first OXA-181-producing strain in China. blaOXA-181 was found sequence type 410 (ST410) Escherichia coli WCHEC14828 from a Chinese patient without recent travel history. Genome sequencing and conjugation experiments were performed. carried on 51-kb self-transmissible IncX3 plasmid linked with qnrS1, quinolone resistance gene. introduced onto ColE2-type plasmid, plasmids have potential to mediate dissemination of blaOXA-181.
Chronic graft-versus-host disease (cGVHD)-related serositis is rare, and primarily presents as polyserous effusions. The low incidence differential diagnosis impose significant challenges to the prompt effective treatment of disease. Here we report a 57-year-old woman who experienced recurrent steroid-refractory cGVHD-related after allogeneic hematopoietic stem cell transplantation (allo-HSCT). We thus added baricitinib, specific JAK1/2 inhibitor, into regimen for patient's clinical symptoms...
Cyclooxygenase-2 (COX-2) has recently been considered to promote lymphangiogenesis by up-regulating vascular endothelial growth factor-C (VEGF-C) in breast and lung cancer. However, the impact of COX-2 on gastric cancer remains unclear. This study aims test expression VEGF-C human cancer, analyze correlation with lymphatic vessel density (LVD), clinicopathologic features survival prognosis.Using immunohistochemistry, COX-2, level LVD were analyzed 56 R0-resected primary adenocarcinomas,...
BK virus-associated hemorrhagic cystitis (BKV-HC) is a severe complication after allogeneic hematopoietic stem cell transplantation. So far, no specific antiviral drug with proven efficacy has been approved for treating BKV-HC. Leflunomide an immunosuppressive activity and used in BKV-associated nephropathy renal This the first report on safety of leflunomide treatment From January 2006 to 2009, 89 patients received transplantation, among them, 18 were identified as having BKV-HC, 20%...
Background: Progressive multifocal leukoencephalopathy (PML) is characterized by demyelination in the central nervous system. It caused infection with human polyomavirus 2 and has a poor prognosis. Therapeutic strategies involve restoring immune function and/or discontinuing immunosuppressive treatment. Immune checkpoint inhibitors such as those targeting programmed death receptor-1 (PD-1) can alleviate PML T cell function. There are no case reports on use of PD-1 inhibitor, Sintilimab, for...
Background Melphalan formulated with modified cyclodextrin (β-cyclodextrin sulfobutyl ether sodium [BSES]) is widely used before autologous stem cell transplantation (ASCT) in patients multiple myeloma (MM) because of its favorable solubility and stability versus conventional melphalan, but the efficacy safety data on Chinese MM who subsequently underwent ASCT are still limited. Methods In this prospective, open-label, non-randomized, interventional study, a total 67 were eligible for...
The gastrointestinal tract is the most common primary site of extranodal lymphomas, whereas natural killer/T-cell (GINKT) lymphomas are relatively rare. To date, neither prognostic characteristics nor clinical features or optimal therapeutic approach for GINKT has yet been defined.In this study, a retrospective analysis was carried out on data obtained from 47 patients diagnosed with lymphoma between May 1999 and August 2011 at West China Hospital.Patients had median age 37 years....
Previous studies highlight the need for a more active conditioning therapy in high-risk or refractory and relapsed lymphomas. Our preclinical research shows that histone deacetylase inhibitors, such as either vorinostat chidamide, sensitize lymphoma cells to cytotoxic combination of cladribine, gemcitabine busulfan, leading cell apoptosis. To evaluate efficacy this chidamide-cladribine-gemcitabine-busulfan (ChiCGB) new therapy, we conducted Phase II trial, described here. Patients with...
Camrelizumab (a humanized high-affinity IgG4 mAb against programmed death-l) showed potent antitumor activity, well tolerance and controllable safety in patients with relapsed or refractory classical Hodgkin lymphoma (r/r cHL), based on the primary analysis of a Phase 2 study. Here, we present extended follow-up outcomes. Seventy-five who had failed to achieve remission experienced progression after autologous stem cell transplantation received at least two lines systemic chemotherapies were...
Abstract CD7 has been found to be a promising chimeric antigen receptor (CAR) T cell target in several clinical trials. However, its expression on normal cells poses additional challenges CD7-directed CAR therapy, such as complete fratricide, contamination with malignant cells, and immune suppression due T-cell aplasia. By taking advantage of evolved affinity between ligand receptor, we constructed the extracellular domain SECTM1, natural CD7, recognition domain. SECTM1 killed majority high...
Accurate baseline clinical staging is critical to inform treatment decision-making for patients with gastric cancers. Peritoneal metastasis (PM) the most common form of in cancer and mainly diagnosed by diagnostic laparoscopy peritoneal lavage evaluation. However, invasive less cost-effective. It urgent develop a safe, fast non-invasive functional imaging method verify cancer. The aim our study was evaluate proportion whom 68Ga-FAPI-04 positron emission tomography/CT (PET/CT) led change...
Acute myeloid leukemia (AML) is a serious, life-threatening hematological malignancy. The treatment outcome of relapsed or refractory AML patients remains dismal, and new options are needed. Chimeric antigen receptor (CAR) T cells have been successful in improving the prognosis for B-lineage acute lymphoblastic lymphoma by targeting CD19. However, CAR T-cell therapy still elusive, owing to lack tumor-specific cell surface spare hematopoietic stem (HSCs). This study generated novel...