A5090183007- Comparative Animal Anatomy Studies
- Skin Protection and Aging
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cystic Fibrosis Research Advances
- Organ Transplantation Techniques and Outcomes
- Intestinal and Peritoneal Adhesions
- Heme Oxygenase-1 and Carbon Monoxide
- Orthopedic Surgery and Rehabilitation
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Mycobacterium research and diagnosis
- Cancer-related molecular mechanisms research
- Medical Imaging and Pathology Studies
- Liver Disease and Transplantation
- Hair Growth and Disorders
- Protein Degradation and Inhibitors
- Advanced biosensing and bioanalysis techniques
- Cardiomyopathy and Myosin Studies
- Reproductive Physiology in Livestock
- Nonmelanoma Skin Cancer Studies
- Acne and Rosacea Treatments and Effects
- Skin and Cellular Biology Research
- Coronary Artery Anomalies
- Rabbits: Nutrition, Reproduction, Health
- Cholesterol and Lipid Metabolism
Oil and Natural Gas Corporation (India)
2025
Sri Venkateswara Medical College and Ruia Hospital
2019-2023
Bharath University
2023
University of Alabama at Birmingham
2011-2022
P.V. Narsimha Rao Telangana Veterinary University
2016-2020
Sri Krishnadevaraya University
2016
Bipar
2013
Centre for DNA Fingerprinting and Diagnostics
2011
Molecular Oncology (United States)
2010
State Key Laboratory of Molecular Oncology
2010
Pleural mesothelial cells (PMCs), which are derived from the mesoderm, exhibit an extraordinary capacity to undergo phenotypic changes during development and disease. PMC transformation trafficking has a newly defined role in idiopathic pulmonary fibrosis (IPF); however, contribution of Wilms' tumor 1 (Wt1)-positive PMCs generation pathognomonic myofibroblasts remains unclear. were obtained IPF lung explants healthy donor lungs that not used for transplantation. Short hairpin Wt1-knockdown...
The origin of the myofibroblast in fibrotic lung disease is uncertain, and no effective medical therapy for fibrosis exists. We have previously demonstrated that transforming growth factor-β1 (TGF-β1) induces pleural mesothelial cell (PMC) transformation into myofibroblasts haptotactic migration <i>in vitro</i>. Whether PMC differentiation occurs vivo</i>, whether this response can be modulated therapeutic benefit, unknown. Here, using mice recombinant green fluorescent protein (GFP) driven...
Abstract Gas Hydrates represent vast energy resources and are considered to be a potential clean fuel of the future. Under National Hydrate Program (NGHP), DGH ONGC have been carrying out research work for exploration development gas hydrates in Indian Offshore. Based on geological, geophysical geochemical studies, coring/drilling/logging which were carried during NGHP-01, 2006 NGHP-02, 2015, several hydrate prospective areas identified Krishna-Godavari (KG) Mahanadi (MN) deep offshore....
Natural plant products have been widely used in controlling cancer with fewer or no side effects and the use of extracts as complementary to synthetic medicine is gaining increased popularity. Members Andrographis plants possess important medicinal properties. In present study, anti-cancerous properties nallamalayana (AN) were tested on A375 B16F10 skin melanoma cell lines. The leaf AN significantly reduced viability survival lines, achieved by MTT assay clonogenic assays, respectively....
Lipopolysaccharide (LPS) serves as the interface between gram-negative bacteria (GNB) and innate immune response in respiratory epithelial cells (REC). Herein, we describe a novel biological role of LPS that permits GNB to persist tract through inducing CFTR mucociliary dysfunction. reduced cystic fibrosis transmembrane conductance regulater (CFTR)-mediated short-circuit current mammalian REC Ussing chambers nearly abrogated single channel activity (defined forskolin-activated Cl- currents)...
Protective effects of UV-B radiation against nonmelanoma skin cancer (NMSC) are exerted via signaling mechanisms involving the vitamin D receptor (VDR). Recent studies have examined single-nucleotide polymorphisms (SNPs) in VDR, resulting contradictory findings as to whether these increase a person's risk for NMSC.To examine VDR gene associated with development NMSC and demographic characteristics participants.This case-control study recruited 100 individuals who received diagnosis were...
Synonymous mutations, such as I507-ATCÅATT, in deletion of Phe508 cystic fibrosis transmembrane conductance regulator (ΔF508 CFTR), the most frequent disease-associated mutant CFTR, may affect protein biogenesis, structure, and function contribute to an altered disease phenotype. Small-molecule drugs are being developed correct ΔF508 CFTR. To understand correction mechanisms consequences synonymous we analyzed effect mechanistically distinct correctors, corrector 4a (C4) lumacaftor (VX-809),...
The most common mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene leads to deletion of phenylalanine at position 508 (ΔF508) CFTR protein and causes multiple folding functional defects. Contrary large-scale efforts by industry academia, no significant therapeutic benefit has been achieved with a single "corrector". Therefore, investigations concentrate on drug combinations. Orkambi (Vertex Pharmaceuticals), first FDA-approved for treatment (CF) caused this...
Abstract Aberrant activation of multiple complex signaling pathways underlies the pathogenesis rhabdomyosarcoma (RMS), which remains a cause mortality in approximately 30% children with RMS. Bromodomain and extraterminal (BET) domain chromatin remodeling regulates several these pathways. Here, we targeted bromodomain 4 (BRD4) combination another molecular metabolic tumor driver, Akt/mTOR pathway, to provide highly effective treatment for this neoplasm. We demonstrated that nexus two RMS...
The CDKN2A locus encodes for tumor suppressor genes p16INK4a and p14Arf which are frequently inactivated in human skin tumors. purpose of this study was to determine the relationship between loss INK4a/Arf activity inflammation development ultraviolet (UV) radiation-induced Panels INK4a/Arf-/- mice wild-type (WT) were treated with a single dose UVB (200 mJ/cm2 ). For long-term studies, these irradiated ) three times weekly 30 weeks. At end experiment, tissues harvested from assayed...
Background: Peritonitis is defined as inflammation of the serosal membrane that lines abdominal cavity and organs contained therein. often caused by introduction infection into otherwise sterile peritoneal environment through perforation bowel, such ruptured appendix or colonic diverticulum. The disease may also be a chemically irritating material, gastric acid from perforated ulcer. secondary to gastrointestinal tract, common occurrence in this country, requires emergency surgical...
Introduction The important factors determining the treatment of extensor tendon injuries include anatomical zone, type injury, mode chronicity, and pathology adjacent tissues (principally skin, bone, joints). Very few studies have collectively studied outcomes all wrist, forearm, hand extensors. Hence, major aim this study was to evaluate results hand, forearm that were treated surgically. Methodology This a hospital-based retrospective done in tertiary teaching hospital South India. A total...
Histological features of renal arteries goat revealed a typical muscular artery structure with three layers within outwards viz., tunica intima, media and adventitia. Abundant sub-endothelial connective tissue was limited by clear undulating internal elastic membrane. Tunica in all arterial segments i.e., proximal, middle distal from aorta to the hilus thicker. More than thirty rows smooth muscle cells were arranged circular fashion media. Their outer boundary fragmented thin wavy adventitia...
Scanning electron micrographic observations of renal arteries goat and pig which revealed a thin tunica intima enveloped by packed layer smooth muscle cells in media both species. Endothelium was wavy outline on internal aspect goats pigs. It presented cushion like foldings were aligned across the longitudinal axis artery. Outer parts anchored fine collagen fibrils elastic fibers to tissue adventitia. In case pig, adventitia relatively thicker than that goat. Internal diameter artery more...