A5045990750- Bioinformatics and Genomic Networks
- Plant-Microbe Interactions and Immunity
- Machine Learning in Bioinformatics
- Genomics and Phylogenetic Studies
- Computational Drug Discovery Methods
- Plant Molecular Biology Research
- Microbial Metabolic Engineering and Bioproduction
- Plant biochemistry and biosynthesis
- Artificial Intelligence in Healthcare
- Plant Pathogenic Bacteria Studies
- Fungal Biology and Applications
- Plant tissue culture and regeneration
- Protein Structure and Dynamics
- Plant Gene Expression Analysis
- Medicinal Plants and Bioactive Compounds
- Metabolomics and Mass Spectrometry Studies
- Transgenic Plants and Applications
- Plant Pathogens and Fungal Diseases
- Plant Stress Responses and Tolerance
- Photosynthetic Processes and Mechanisms
- Plant Parasitism and Resistance
- RNA and protein synthesis mechanisms
- Gene expression and cancer classification
- Polar Research and Ecology
- Metal-Catalyzed Oxygenation Mechanisms
Academy of Scientific and Innovative Research
2014-2025
Institute of Himalayan Bioresource Technology
2015-2025
Council of Scientific and Industrial Research
2013-2017
Biotechnology Research Center
2015
Centre for DNA Fingerprinting and Diagnostics
2010-2012
Madurai Kamaraj University
2009
NAC [no apical meristem (NAM), Arabidopsisthaliana transcription activation factor [ATAF1/2] and cup-shaped cotyledon (CUC2)] proteins belong to one of the largest plant-specific (TF) families play important roles in plant development processes, response biotic abiotic cues hormone signalling. Our genome-wide analysis identified 110 StNAC genes potato encoding for 136 proteins, including 14 membrane-bound TFs. The physical map positions on 12 chromosomes were non-random, 40 found be...
Abstract The MADS-box transcription factors play essential roles in various processes of plant growth and development. In the present study, phylogenetic analysis 142 apple proteins with that other dicotyledonous species identified six putative Dormancy-Associated (DAM) four Flowering Locus C-like (FLC-like) proteins. order to study expression genes, RNA-seq 3 apical 5 spur bud stages during dormancy, 6 flower 7 fruit development was performed. dramatic reduction two MdDAMs , MdMADS063...
Nucleotide binding site leucine-rich repeats (NBS-LRR) disease resistance proteins play an important role in plant defense against pathogen attack. A number of recent studies have been carried out to identify and characterize NBS-LRR gene families many species. In this study, we identified family comprising 1015 NBS-LRRs using highly stringent computational methods. These were characterized on the basis conserved protein motifs, duplication events, chromosomal locations, phylogenetic...
Bacterial lipases with activity spanning over a broad temperature and substrate range have several industrial applications. An efficient enzyme-producing bacterium Chryseobacterium polytrichastri ERMR1:04, previously reported from Sikkim Himalaya, was explored for purification characterization of cold-adapted lipase. Optimum lipase production observed in 1% (v/v) rice bran oil, pH 7 at 20°C. Size exclusion hydrophobic interaction chromatography purified the enzyme up to 21.3-fold predicting...
Variations are mostly due to nonsynonymous single nucleotide polymorphisms (nsSNPs), some of which associated with certain diseases. Phenotypic effects a large number nsSNPs have not been characterized. Although several methods developed predict the as "disease" or "neutral," there is still need for development improved prediction accuracies. We, therefore, support vector machine (SVM) based method named Hansa uses novel set discriminatory features classify into disease (pathogenic) and...
Abstract Nitrate is the main source of inorganic nitrogen for plants, which also act as signaling molecule. Present study was aimed to understand nitrate regulatory mechanism in Brassica juncea cultivars, with contrasting nitrogen-use-efficiency (NUE) viz . Pusa Bold (PB, high-NUE) and Jai Kisan (PJK, low-NUE), employing RNA-seq approach. A total 4031, 3874 3667 genes PB 2982, 2481 2843 PJK were differentially expressed response early, low (0.25 mM KNO 3 ), medium (2 ) high (4 treatments,...
A light pink coloured bacterial strain ERGS5:01 isolated from glacial stream water of Sikkim Himalaya was affiliated to
Virtual screening (VS) aids in prioritizing unknown bio-interactions between compounds and protein targets for empirical drug discovery. In standard VS exercise, roughly 10% of top-ranked molecules exhibit activity when examined biochemical assays, which accounts many false positive hits, making it an arduous task. Attempts conquering false-hit rates were developed through either ligand-based or structure-based separately; however, nonetheless performed remarkably well. Here, we present...
Oral squamous cell carcinoma (OSCC) is associated with substantial mortality and morbidity but, OSCC can be difficult to detect at its earliest stage due molecular complexity clinical behavior. Therefore, identification of key gene signatures an early will highly helpful.The aim this study was identify genes progression stages. Gene expression profiles were classified into cancer stage-related modules, i.e., groups that are significantly related a stage. For prioritizing the candidate genes,...
Abstract Objective Sudden unexpected death in epilepsy (SUDEP) is a major outcome of cardiac dysfunction patients with epilepsy. In continuation our previous work, the present study was envisaged to explore key regulators responsible for damage associated chronic seizures using whole transcriptome and proteome analysis rat model temporal lobe Methods A standard lithium‐pilocarpine protocol used induce recurrent rats. The isolated heart tissue subjected transcriptomic proteomic analysis. An...
Background Hypohidrotic/anhidrotic ectodermal dysplasia (HED) is a rare Mendelian disorder affecting tissues. The disease primarily caused by inactivation of any one three genes, namely ectodysplasin A1 (EDA-A1), which encodes ligand belonging to the tumour necrosis factor (TNF) superfamily; A receptor (EDAR), encoding EDA-A1 and receptor-associated death domain (EDARADD), an adaptor protein. X-linked recessive predominant form HED, as well autosomal dominant (EDAR EDARADD) inheritance...
The present work was conducted to understand the basis of adaptation in Caragana jubata its niche environment at high altitude cold desert Himalaya. Molecular data showed predominance genes encoding chaperones and those involved growth development low temperature (LT), a major cue operative altitude. Importantly, these expressed C. natural habitat. Their homologues Arabidopsis thaliana, Oryza sativa, Glycine max did not exhibit similar trend gene expression LT. Constitutive quick...
Abstract Aims Geophytic plants have evolved to develop underground storage organs (USO) in the active growing season withstand harsh environments as well coordinate growth and reproduction when conditions are favourable. Saffron is an autumn flowering geophyte expensive spice crop restricted certain geographical locations world. Saffron, being sterile, does not produce seeds thus propagates only through corms, quality of which determines its yield. Corm development saffron unexplored...
Enzymes are known to be denatured upon boiling, although Cu,Zn superoxide dismutase of Potentilla atrosanguinea (Pot-SOD) retains significant catalytic activity even after autoclaving (heating at 121 °C a pressure 1.1 kg per square cm for 20 min). The polypeptide backbone Pot-SOD consists 152 amino acids with central core spanning His45 Cys145 that is involved in coordination Cu(2+) and Zn(2+) ions. While the essential imparting structural stability enzyme, role sequences flanking was not...