A5047412400- Oral microbiology and periodontitis research
- Lipid Membrane Structure and Behavior
- Advanced Photocatalysis Techniques
- Ionic liquids properties and applications
- Advanced biosensing and bioanalysis techniques
- Dental Health and Care Utilization
- Gas Sensing Nanomaterials and Sensors
- Bacterial biofilms and quorum sensing
- Natural product bioactivities and synthesis
- Botanical Research and Applications
- Graphene and Nanomaterials Applications
- Surfactants and Colloidal Systems
- Chemical synthesis and alkaloids
- Streptococcal Infections and Treatments
- Oral Health Pathology and Treatment
- Agricultural Science and Fertilization
- Bacteriophages and microbial interactions
- Tuberculosis Research and Epidemiology
- Biosensors and Analytical Detection
- Microfluidic and Capillary Electrophoresis Applications
- Wound Healing and Treatments
- Dental Research and COVID-19
- Essential Oils and Antimicrobial Activity
- Infectious Diseases and Tuberculosis
- Phytochemistry and Bioactivity Studies
Indian Institute of Technology Delhi
2019-2025
National Institute for Research in Tribal Health
2022-2025
Central University of Himachal Pradesh
2016-2025
Deenbandhu Chhotu Ram University of Science and Technology
2024-2025
Central University of Rajasthan
2024-2025
Institute of Himalayan Bioresource Technology
2021-2024
Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu
2024
University of L'Aquila
2024
MedStar Washington Hospital Center
2024
Liaquat National Hospital
2024
In the past decade, researchers have put forth a lot of efforts to conceive precise structural arrangement and properties deep eutectic solvents (DESs) that provide designer pathways in order broaden application domain these solvents. However, contributions are limited few experimental computational techniques. this review, we encompassed techniques employed establish structure–property relationship bulk DESs along with recent growth witnessed from perspective. The nanostructuring plays an...
Micro- and nanofluidics have enabled the possibility of miniaturized analytical systems, which are commonly known as lab-on-a-chip (LOC) devices.
Plasma membrane (PM) simulations at longer length and time scales nearly atomistic resolution can provide invaluable insights into cell signaling, apoptosis, lipid trafficking, raft formation. We propose a coarse-grained (CG) model of mammalian PM considering major head groups distributed asymmetrically across the bilayer validate against structural properties from simulation. Using proposed CG model, we identify recurring pattern in passive collective cholesterol transbilayer motion study...
Tuberculosis (TB), a disease caused by Mycobacterium tuberculosis (M.tb), takes one human life every 15 s globally. Disease relapse occurs due to incomplete clearance of the pathogen and reactivation antibiotic tolerant bacilli. M.tb, like other bacterial pathogens, creates an ecosystem biofilm formed several proteins including cyclophilins. We show that M.tb cyclophilin peptidyl-prolyl isomerase (PpiB), essential gene, is involved in formation tolerance anti-mycobacterial drugs. predicted...
A large body of emerging evidence has revealed the role p38/MK2 and PI3K/Akt/GSK3β cascades in orchestrating process colitis. Rutin, a bioflavonoid present many fruits vegetables, been recognized to offer therapeutic attributes acute However, its chronic colitic condition not yet delineated reference signalling. The investigation assessed efficacy underlying molecular mechanism rutin alleviating DSS-induced analysis signalling pathways demonstrated robust activation...
The global concern over the environmental impact and challenges associated with use of conventional solvents in biotransformation processes have pushed search for alternative solvents. Recently, deep eutectic (DESs) appeared as a promising replacement better biocompatibility been postulated to hold great potential protein engineering crystallization processes. In this context, herein, we investigated effect reline (a choline chloride : urea mixture 1 2 proportion) DES its pure hydrated forms...
Rapid emergence of multidrug-resistant bacterial strains has posed a global threat to public health. Hospital-acquired infections, especially in diabetic and burn patients, severely impede the process wound healing, thereby causing high mortality. This calls for developing new biomaterial that synergistically destroys pathogenic also helps promoting healing without any resistance generation. A highly potent antibacterial agent been developed by integrating bactericidal properties MoS2...
Factors governing the stability and activity of proteins enzymes in nonaqueous solvents have just been started to be explored. Because their benign economically viable nature, deep eutectic (DESs) are being seen as an alternative media many biotransformation processes. The present study exploits changes conformation hen egg white lysozyme (HEWL) presence reline (a mixture choline chloride urea) reline/water mixtures using atomistic molecular dynamics simulations. structure was found...
Drug discovery has traditionally been a time consuming and expensive endeavor. Additionally, drugs weren’t as effectively designed those that are being predicted developed through AI ML today. Machine learning is form of artificial intelligence develops evolves based on experience (similarly to the human mind), more recently utilized in drug design. The integration into development process allowed for higher target precision, lower toxicity, better dosage formulations. generally introduced...
Breast cancer continues to be the most common globally and a major contributor cancer-related mortality. Although progress has been made in treatment, considerable challenges remain due intricate interplay of various signaling pathways, transcription factors, tumor suppressor genes. Current therapies, including chemotherapy, radiotherapy, targeted often come with limitations such as toxicity immune suppression highlighting need for safer more effective alternatives. Phytochemicals offer...
Human Immunodeficiency Virus (HIV) infection significantly worsens Tuberculosis meningitis (TBM) outcomes, leading higher mortality rate in HIV-positive patients compared to HIV-negative individuals. Objectives: To find out the frequency of HIV Infected Patients with TBM and their outcome as compare without infection. Methods: This cross-sectional-observational study was conducted at Jinnah Postgraduate Medical Center Karachi, from September 2020 October 2024. All diagnosed on clinical...